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Hanmin Guo, Alexander E. Urban, Wing H. Wong
Prioritizing disease-related rare variants by integrating gene expression data
PLOS Genetics, 20(9): e1011412, 2024.
[online]
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Bo Zhou, Joseph G. Arthur, Hanmin Guo, Taeyoung Kim, Yiling Huang, Reenal Pattni, Tao Wang, Soumya Kundu, Jay X.J. Luo, HoJoon Lee, Daniel C. Nachun, Carolin Purmann, Emma M. Monte, Annika K. Weimer, Ping-Ping Qu, Minyi Shi, Lixia Jiang, Xinqiong Yang, John F. Fullard, Jaroslav Bendl, Kiran Girdhar, Minsu Kim, Xi Chen, PsychENCODE Consortium, William J. Greenleaf, Laramie Duncan, Hanlee P. Ji, Xiang Zhu, Giltae Song, Stephen B. Montgomery, Dean Palejev, Heinrich zu Dohna, Panos Roussos, Anshul Kundaje, Joachim F. Hallmayer, Michael P. Snyder, Wing H. Wong, Alexander E. Urban
Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders
Cell, 2024.
[online]
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Bo Zhou, Carolin Purmann, Hanmin Guo, GiWon Shin, Yiling Huang, Reenal Pattni, Qingxi Meng, Stephanie U. Greer, Tanmoy Roychowdhury, Raegan N. Wood, Marcus Ho, Heinrich zu Dohna, Alexej Abyzov, Joachim F. Hallmayer, Wing Hung Wong, Hanlee P. Ji, and Alexander E. Urban
Resolving the 22q11.2 deletion using CTLR-Seq reveals chromosomal rearrangement mechanisms and individual variance in breakpoints
Proc Natl Acad Sci U S A, July 23, 2024, 121 (31) e2322834121
[online]
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Qiao Liu, Zhongren Chen, Wing Hung Wong
An encoding generative modeling approach to dimension reduction and covariate adjustment in causal inference with observational studies
Proc Natl Acad Sci U S A, June 4, 2024, 121 (23) e2322376121
[online]
2023 |
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Yingxin Lin, Tung-Yu Wu, Xi Chen, Sheng Wan, Brian Chao, Jingxue Xin, Jean Yang, Wing Hung Wong, and Y.X. Rachel Wang
Data integration and inference of gene regulation using single-cell temporal multimodal data with scTIE
Genome Research (2023): gr-277960.
[online]
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Shuo Li, Xiaohui Ni, Qiao Liu, Wenyuan Li, Mary L. Stackpole, Yonggang Zhou, Arjan Gower, Kostyantyn Krysan, Preeti Ahuja, David S. Lu, Steven S. Raman, William Hsu, Denise R. Aberle, Clara E. Magyar, Samuel W. French, Steven-Huy B. Han, Edward B. Garon, Vatche G. Agopian, Wing Hung Wong, Steven M. Dubinett, and Xianghong Jasmine Zhou
Comprehensive tissue deconvolution of cell-free DNA by deep learning for disease diagnosis and monitoring
Proc Natl Acad Sci U S A, July 3, 2023; 120 (28) e2305236120
[online]
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Zheng Wei, Kui Hua, Lei Wei, Shining Ma, Rui Jiang, Xuegong Zhang, Yanda Li, Wing H. Wong, and Xiaowo Wang
NeuronMotif: Deciphering cis-regulatory codes by layer-wise demixing of deep neural networks
Proc Natl Acad Sci U S A, April 6, 2023; 120 (15): e2216698120
[online]
-
Linxi Liu, Danga Li, Wing Hung Wong
Convergence rates of a class of multivariate density estimation methods based on adaptive partitioning
Journal of Machine Learning Research, 24 (2023) 1-64
[online]
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Qiao Liu, Zhongren Chen, Wing Hung Wong
CausalEGM: a general causal inference framework by encoding generative modeling
arXiv:2212.05925
[preprint]
2022 |
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Xianghong Zhou, Mary Stackpole, Weihua Zeng, Shuo Li, Chun-Chi Liu, Yonggang Zhou, Shanshan He, Angela Yeh, Ziye Wang, Fengzhu Sun, Qingjiao Li, Zuyang Yuan, Asli Yildirim, Pin-Jung Chen, Paul Winograd, Benjamin Tran, Yi-Te Lee, Paul Li, Zorawar Noor, Megumi Yokomizo, Preeti Ahuja, Yazhen Zhu, Hsian-Rong Tseng, James Tomlinson, Edward Garon, Samuel French, Clara Magyar, Sarah Dry, Clara Lajonchere, Daniel Geschwind, Gina Choi, Sammy Saab, Frank Alber, Wing Wong, Steven Dubinett, Denise Aberle, Vatche Agopian, Steven-Huy Han, Xiaohui Ni, and Wenyuan Li
Cost-effective Methylome Sequencing of Cell-free DNA for Accurately Detecting and Locating Cancer
Nature communications 13.1 (2022): 5566
[online]
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Xueqiu Lin, Yanxia Liu, Shuai Liu, Xiang Zhu, Lingling Wu, Yanyu Zhu, Dehua Zhao, Xiaoshu Xu, Augustine Chemparathy, Haifeng Wang, Yaqiang Cao, Muneaki Nakamura, Jasprina N. Noordermeer, Marie La Russa, Wing Hung Wong, Keji Zhao, and Lei S. Qi
Nested epistasis enhancer networks for robust genome regulation
Science, 377(6610), 1077-1085
[online]
-
Wanwen Zeng, Qiao Liu, Qijin Yin, Rui Jiang and Wing Hung Wong
HiChIPdb: a comprehensive database of HiChIP regulatory interactions
Nucleic Acids Research, (2022)
[online]
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Xi Xi, Haochen Li, Shengquan Chen, Tingting Lv, Tianxing Ma, Rui Jiang, Ping Zhang, Wing Hung Wong and Xuegong Zhang
Unfolding the genotype-to-phenotype black box of cardiovascular diseases through cross-scale modeling
Iscience 25.8 (2022): 104790
[online]
-
Qiao Liu, Kui Hua, Xuegong Zhang, Wing Hung Wong, and Rui Jiang
DeepCAGE: Incorporating Transcription Factors in Genome-wide Prediction of Chromatin Accessibility
Genomics, Proteomics & Bioinformatics 20.3 (2022): 496-507
[online]
-
Zhana Duren, Fengge Chang, Fnu Naqing, Jingxue Xin, Qiao Liu and Wing Hung Wong
Regulatory analysis of single cell multiome gene expression and chromatin accessibility data with scREG
Genome Biol 23, 114 (2022)
[online]
-
Hangjin Jiang, Xuhui Huang, Han Li, Wing Hung Wong, Xiaodan Fan
Revealing Free Energy Landscape from MD Data via Conditional Angle Partition Tree
IEEE/ACM Transactions on Computational Biology and Bioinformatics 20.2 (2022): 1384-1394
[online]
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Yingxin Lin, Tung-Yu Wu, Sheng Wan, Jean Y.H. Yang, Wing H. Wong and Y. X. Rachel Wang
scJoint integrates atlas-scale single-cell RNA-seq and ATAC-seq data with transfer learning
Nature Biotechnology. 2022 Jan 20:1-8
[online]
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Shining Ma, Xi Chen, Xiang Zhu, Philip S. Tsao and Wing Hung Wong
Leveraging cell type-specific regulatory networks to interpret genetic variants in abdominal aortic aneurysm
Proc Natl Acad Sci U S A, 2022 Jan 4; 119(1): e2115601119
[online]
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. Juan A. Ferrer-Bonsoms, Xabier Morales, Pegah T. Afshar, Wing H. Wong and Angel Rubio
On the identifiability of the isoform deconvolution problem: application to select the proper fragment length in an RNAseq library
Bioinformatics, Volume 38, Issue 6, 15 March 2022, Pages 1491–1496
[online]
2021 |
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Wing Hung Wong
An equation for the identification of average causal effect in nonlinear models
Statistica Sinica. DOI 10.5705/ss.202021.0191
[online]
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Yunzhang Zhu, Xiaotong Shen, Hui Jiang, and Wing Hung Wong
Collaborative Multilabel Classification
Journal of the American Statistical Association (2021): 1-12
[online]
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Duren Zhana, Wenhui Sophia Lu, Joseph G. Arthur, Preyas Shah, Jingxue Xin, Francesca Meschi, Miranda Lin Li, Corey M. Nemec, Yifeng Yin, and Wing Hung Wong
Sc-compReg enables the comparison of gene regulatory networks between conditions using single-cell data
Nature Communications 12, 4763 (2021)
[online]
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David G. Gennert, Rachel C. Lynn, Jeff M. Granja, Evan W. Weber, Maxwell R. Mumbach, Yang Zhao, Zhana Duren, Elena Sotillo, William J. Greenleaf, Wing H. Wong, Ansuman T. Satpathy, Crystal L. Mackall, and Howard Y. Chang
Dynamic chromatin regulatory landscape of human CAR T cell exhaustion
Proc Natl Acad Sci USA July 27, 2021 118 (30) e2104758118
[online]
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Shuo Li, Zorawar S. Noor, Weihua Zeng, Mary L. Stackpole, Xiaohui Ni, Yonggang Zhou, Zuyang Yuan, Wing Hung Wong, Vatche G. Agopian, Steven M. Dubinett, Frank Alber, Wenyuan Li, Edward B. Garon, and Xianghong Jasmine Zhou
Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis
Nature Communications 12, 4172 (2021)
[online]
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Xiang Zhu, Duren Zhana, Wing Hung Wong
Modeling regulatory network topology improves genome wide analysis of complex human traits
Nature communications 12, 2851 (2021)
[online]
-
Qiao Liu, Jiaze Xu, Rui Jiang, Wing Hung Wong
Density estimation using deep generative neural networks
Proceedings of the National Academy of Sciences Apr 2021, 118 (15) e2101344118
[online]
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Qiao Liu, Shengquan Chen, Rui Jiang, Wing Hung Wong
Simultaneous deep generative modelling and clustering of single-cell genomic data
Nature Machine Intelligence, 2021, Published: May 10, 2021
[online]
-
Zhanying Feng, Zhana Duren, Ziyi Xiong, Sijia Wang, Fan Liu, Wing Hung Wong, Yong Wang
Reconstructing human regulatory network of cranial neural crest cell and annotating variants in developmental context
Communications Biology (2021) 4:442
[online]
2020 |
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Sheng Wan , Tung-Yu Wu, Heng-Wei Hsu , Wing Hung Wong , and Chen-Yi Lee
Feature Consistency Training with JPEG Compressed Images
IEEE Transactions on Circuits and Systems for Video Technology, Vol. 30, No. 12, December 2020, pages 4769-4780
[online]
-
Wenran Li, Zhana Duren, Rui Jiang, and Wing Hung Wong
A method for scoring the cell type-specific impacts of noncoding variants in personal genomes
PNAS September 1, 2020 117 (35) 21364-21372; first published August 17, 2020
[online]
-
Ben Dai, Xiaotong Shen, and Wing Wong
Coupled generation
Journal of the American Statistical Association, 2020
[online]
-
Jingxue Xin, Hui Zhang, Yaoxi He, Zhana Duren, Caijuan Bai, Lang Chen, Xin Luo, Dong-Sheng Yan, Chaoyu Zhang, Xiang Zhu, Qiuyue Yuan, Zhanying Feng, Chaoying Cui, Xuebin Qi, Ouzhuluobu, Wing Hung Wong, Yong Wang & Bing Su
Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
Nature Communications 11, 4928 (2020)
[online]
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Zhana Duren, Xi Chen, Jingxue Xin, Yong Wang, and Wing Hung Wong
Time course regulatory analysis based on paired expression and chromatin accessibility data
Genome Res. 2020. 30: 622-634. Published in Advance March 18, 2020
[online]
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Xianglong Zhang, David Hong, Shining Ma, Thomas Ward, Marcus Ho, Reenal Pattni, Zhana Duren, Atanas Stankov, Sharon Bade Shrestha, Joachim Hallmayer, Wing Hung Wong, Allan L Reiss, Alexander E Urban
Integrated functional genomic analyses of Klinefelter and Turner syndromes reveal global network effects of altered X chromosome dosage
Proceedings of the National Academy of Sciences (2020), Published: March 3, 2020 117 (9) 4864-4873; first published February 18, 2020
[online]
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Zhixiang Lin, Mahdi Zamanighomi, Timothy Daley, Shining Ma, and Wing Hung Wong
Model-based approach to the joint analysis of single-cell data on chromatin accessibility and gene expression
Statist. Sci., Volume 35, Number 1 (2020), 2-13
[online]
2019 |
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Wanwen Zeng, Xi Chen, Zhana Duren, Yong Wang, Rui Jiang, Wing Hung Wong
DC3 is a method for deconvolution and coupled clustering from bulk and single-cell genomics data
Nature Communications volume 10, Article number: 4613 (2019)
[online]
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Leying Guan, Xi Chen and Wing Hung Wong
Detecting Strong Signals in Gene Perturbation Experiments: An Adaptive Approach With Power Guarantee and FDR Control
Journal of the American Statistical Association (2019), Published: 14 August 2019
[online]
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Wenran Li, Wing Hung Wong and Rui Jiang
DeepTACT: predicting 3D chromatin contacts via bootstrapping deep learning
Nucleic Acids Research (2019), Published: 14 March 2019
[online]
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Lingjie Li, Yong Wang, Jessica L.Torkelson, Gautam Shankar, Jillian M.Pattison, Hanson H.Zhen, Fengqin Fang, Zhana Duren, JingxueXin, Sadhana Gaddam, Sandra P.Melo, Samantha N.Piekos, Jiang Li, Eric J.Liaw, Lang Chen, Rui Li, Marius Wernig, Wing H. Wong, Howard Y. Chang, Anthony E. Oro
TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment
Cell Stem Cell (2019), Published: 24 January 2019
[online]
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Qigang Li, Keyan Zhao, Carlos D. Bustamante, Xin Ma, Wing H. Wong
Xrare: a machine learning method jointly modeling phenotypes and genetic evidence for rare disease diagnosis
Genetics in Medicine (2019), Published: 24 January 2019
[online]
Software
[download]
2018 |
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Bo Zhou, Joseph G. Arthur, Steve S. Ho, Reenal Pattni, Yiling Huang, Wing H. Wong & Alexander E. Urban
Extensive and deep sequencing of the Venter/HuRef genome for developing and benchmarking genome analysis tools
Scientific Data volume 5, Article number: 180261 (2018)
[online]
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Bo-Cheng Lai, Tung-Yu Wu, Tsou-Han Chiu, Kun-Chun Li, Chia-Ying Lee, Wei-Chen Chien, Wing Hung Wong
Towards high performance data analytic on heterogeneous many-core systems: A study on Bayesian sequential partitioning
J. Parallel Distrib. Comput.(2018)
[online]
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Timothy P. Daley, Zhixiang Lin, Xueqiu Lin, Yanxia Liu, Wing H. Wong and Lei S. Qi
CRISPhieRmix: a hierarchical mixture model for CRISPR pooled screens
Genome Biology (2018) 19:159
[online]
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Bai Jiang, Tung-Yu Wu, Yifan Jin and Wing H. Wong
Convergence of contrastive divergence algorithm in exponential family
Annals of Statistics, Volume 46, Number 6A (2018), 3067-3098 arXiv:1603.05729
[online]
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Wenyuan Li, Qingjiao Li, Shuli Kang, Mary Same, Yonggang Zhou, Carol Sun, Chun-Chi Liu, Lea Matsuoka, Linda Sher, Wing Hung Wong, Frank Alber and Xianghong Jasmine Zhou
CancerDetector: ultrasensitive and non-invasive cancer detection at the resolution of individual reads using cell-free DNA methylation sequencing data
Nucleic Acids Research gky423, Published: 12 June 2018
[online]
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Mahdi Zamanighomi, Zhixiang Lin, Timothy Daley, Xi Chen, Zhana Duren, Alicia Schep, William J. Greenleaf, Wing Hung Wong
Unsupervised clustering and epigenetic classification of single cells
Nature Communications volumn 9, Article 2410 (2018)
[online]
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Zhana Duren, Xi Chen, Mahdi Zamanighomi, Wanwen Zeng, Ansuman T. Satpathy, Howard Y. Chang, Yong Wang, and Wing Hung Wong
Integrative analysis of single-cell genomics data by coupled nonnegative matrix factorizations
Proceedings of the National Academy of SciencesJul 2018, 201805681; DOI: 10.1073/pnas.1805681115
[online]
Software
[github]
-
Christopher De Sa, Vincent Chen, Wing Wong
Minibatch Gibbs Sampling on Large Graphical Models
ICML (to appear) arXiv:1806.06086
[online]
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Bai Jiang, Tung-Yu Wu and Wing Hung Wong
Approximate Bayesian Computation with Kullback-Leibler Divergence as Data Discrepancy
AISTATS 2018 (accepted)
2017 |
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Linxi Liu, Dangna Li, Wing H. Wong
partition based Bayesian multivariate density estimation method
Advances in Neural Information Processing Systems2017, 4739-4747
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Chang-Hung Tsai, Wan-Ju Yu, Wing Hung Wong, Chen-Yi Lee
A 41.3/26.7 pJ per Neuron Weight RBM Processor Supporting On-Chip Learning/Inference for IoT Applications
Solid-State Circuits52(10): 2601-2612 (2017)
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Sayed Sahraeian, Marghoob Mohiyuddin, Robert Sebra, Hagen Tilgner, Pegah Tootoonchi Afshar, Kin Fai Au, Narges Bani Asadi, Mark Gerstein, Wing Wong, Michael Snyder, Eric Schadt, and Hugo Lam
Gaining comprehensive biological insights into transcriptome by performing a broad-spectrum RNA-Seq analysis
Nat Communication 201707 5;8(1):59. Epub 2017 Jul 5.
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Ye Henry Li , Dangna Li , Nikolay Samusik, Xiaowei Wang, Leying Guan, Garry P. Nolan, Wing Hung Wong
Scalable multi-sample single-cell data analysis by Partition-Assisted Clustering and Multiple Alignments of Networks
Plos Computational Biology December 27, 2017. https://doi.org/10.1371/journal.pcbi.1005875
[online]
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Mengmeng Wu, Zhixiang Lin, Shining Ma, Ting Chen, Rui Jiang, Wing Hung Wong
Simultaneous inference of phenotype-associated genes and relevant tissues from GWAS data via Bayesian integration of multiple tissue-specific gene networks
Journal of Molecular Cell Biology doi:10.1093/jmcb/mjx059
[online]
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Ava C. Carter, Howard Y. Chang, George Church, Ashley Dombkowski, Joseph R Ecker, Elad Gil, Paul G. Giresi, Hank Greely, William J. Greenleaf, Nir Hacohen, Chuan He, David Hill, Justin Ko, Issac Kohane, Anshul Kundaje, Megan Palmer, Michael P Snyder, Joyce Tung, Alexander E. Urban, Wing Wong (alphabetical ordered)
Challenges and recommendations for epigenomics in precision health from technology developers and end-users
Nature Biotechnology 35(12):1128-1132
[online]
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Xi Chen, Hong Yang, Wing Hung Wong(2017)
Phased Genome Sequencing Through Chromosome Sorting
Methods in Mol.Bio 1551:171-188 doi:10.1038/ng.3449
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