Total Synthesis of Complex Molecules
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  • Paul A. Wender, Clayton T. Hardman, Stephen Ho, Matthew S. Jeffreys, Ryan V. Quiroz, Steven M. Ryckbosch, Akira J. Shimizu, Jack L. Sloane, Matthew C. Stevens, Jana K. Maclaren, "Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV", Science, 2017, 358, 218-223. Abstract, Full Text, PDF.
  • Liu, Bowen; Ramsundar, Bharath; Kawthekar, Prasad; Shi, Jade; Gomes, Joseph; Luu-Nguyen, Quang; Ho, Stephen; Sloane, Jack; Wender, Paul; Pande, Vijay, "Retrosynthetic reaction prediction using neural sequence-to-sequence models", ACS Central Science, 2017, accepted.
  • Brice Albert, Austin Niu, Rashmi Ramani, Robert M. Williams, Garland R. Marshall, Paul A. Wender, Lee Ratner, Alexander B. Barnes, George B. Kyei, "Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analoges display remarkable potency to activate latent HIV without global T-cell activation", Scientific Reports - Nature, August 7, 2017, 7:7456. Full Text, PDF.
  • Matthew D. Marsden, Brian A. Loy, Xiaomeng Wu, Christina M. Ramirez, Adam J. Schrier, Danielle Murray, Akira Shimizu, Steven M. Ryckbosch, Katherine E. Near, Tae-Wook Chun, Paul A. Wender, Jerome A. Zack, "In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication", PLoS Pathogens, September 21, 2017. Full Text, PDF.
  • Steven M. Ryckbosch, Paul A. Wender, Vijay S. Pande, "Molecular Dynamics Simulations Reveal Ligand-controlled Positioning of a Peripheral Protein Complex in Membranes", Nature Comm.., 2017,8, 6.  Abstract, PDF
  • Tapan K. Khan, Paul A. Wender, Daniel L. Alkon; "Bryostatin and its symnthetic analog rescue dermal fibroblasts from stress and contribute to survival and rejuvenation of human skin equivalents"; J. Cellular Physiology, 2017, Abstract, PDF.
  • Rana Abdelnabi, Daryl Staveness, Katherine E. Near, Paul A. Wender, Leen Delang, Johan Neyts, Pieter Leyssen, "Comparative analysis of salicylate-based bryostatin analogs with or without modification at position C26 confirms that the inhibitory effect on chikungunya virus replication also involves a non-PKC-dependent mechanism", Biochemical Pharmacology., 2016, 120, 15-21.  Text, PDF.
  • Wender, P.A.; "Toward the Ideal Synthesis and and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis"; Tetrahedron, 2013, 69(36), pp. 7529-7550. Article.
  • Wender, Paul A.; Billingsley, Kelvin L.; "Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13 Diversified Bryostatin Analogues"; Synthesis, 2013, 45(13)), pp. 1815-1824.PDF
  • Yasuyuki Ogawa, Phillip P. Painter, Dean J. Tantillo, and Paul A. Wender; "Mechanistic and Computational Studies of Exocyclic Stereocontrol in the Synthesis of Bryostatin-like Cis-2, 6-Disubstituted 4-Alkylidenetetrahydropyrans by Prins Cyclization"; J. Org. Chem., 2013, 78(1), pp. 104-115.Abstract, PDF, Supporting Information
  • Wender, Paul A. & Reuber, Jenny; "Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring-Modified Bryologs",Tetrahedron, 2011, 67, 9998-10005. Abstract, PDF.
  • Paul Wender & Adam Schrier; "Total Synthesis of Bryostatin 9", Journal of the American Chemical Society, 2011, 133(24), 9228-9231. Abstract,PDF.
  • Wender, Paul A.; Buschmann, Nicole; Cardin, Nathan B.; Jones, Lisa R.; Kan, Cindy; Kee, Jung-Min; Kowalski, John A.; Longcore, Kate E., “Gateway Synthesis of Daphnane Congeners and Their PKC Affinities and Cell-Growth Activities”, Nature Chemistry, 2011, 3, 615-619. Abstract
  • Adam Schrier, Brian Loy, and Paul A. Wender, “Translating Nature’s Library: the Bryostatins and Function-Oriented Synthesis” Israel J. Chem.,2011, 51, 453-472.
  • Wender, P. A.; D'Angelo, N.; Elitzin, V. I.; Ernst, M.; Jackson-Ugueto, E. E.; Kowalski, J. A.; McKendry, S.; Rehfeuter, M.; Sun, R.; Voigtlaender, D. "Function-Oriented Synthesis: Studies Aimed at the Synthesis and Mode of Action of 1a-Alkyldaphnane Analogues" Org. Lett., 2007, 9, 1829-1832. Abstract, PDF, Supporting Information
  • Wender, P. A.; Bi, F. C.; Buschmann, N.; Gosselin, F.; Kan, C.; Kee, J.-M.; Ohmura, H. "Studies on Oxidopyrylium [5 + 2] Cycloadditions: Toward a General Synthetic Route to the C12-Hydroxy Daphnetoxins" Org. Lett., 2006, 8, 5373-5376. Abstract, PDF, Supporting Information
  • Wender, P. A.; Koehler, M. F. T.; Sendzik, M. "A New Synthetic Approach to the C Ring of Known as Well as Novel Bryostatin Analogues" Org. Lett., 2003, 5, 4549-4552. Abstract, PDF, Supporting Information
  • Wender, P. A.; Hegde, S. G.; Hubbard, R. D.; Zhang, L. "Total Synthesis of (-)-Laulimilide" J. Am. Chem. Soc., 2002, 124, 4956-4967. Abstract,PDF, Supporting Information
  • Wender, P. A.; Hinkle K. W. "Synthesis and Biological Evaluation of A New Class of Bryostatin Analogues: the Role of the C20 Substituent in Protein Kinase C Binding" Tetrahedon Lett. 2000, 41, 6725-6729. PDF
  • Wender, P. A.; Debrabander, J.; Harran, P. G.; Jimenez, J. M.; Koehler, M. F. T.; Lippa, B.; Park, C. M.; Shiozaki, M."Synthesis of the First Members of A New Class of Biologically Active Bryostatin Analogues" J. Am. Chem. Soc. 1998, 120, 4534-4535. PDF, Supporting Information
  • Wender, P. A.; Dore T. M. "A Formal Synthesis of Crinipellin B Based on the Arene-Alkene Meta-Photocycloaddition Reaction" Tetrahedon Lett.1998, 39, 8589-8592. Abstract, PDF
  • Paul A. Wender and Timothy Dore, Condensation and Commentary on: "Radical Carboxylation: Ester Synthesis From Alkyl Iodides, Carbon Monoxide, and Alcohols Under Irradiation Conditions," CHEMTRACTS--ORGANIC CHEMISTRY, 1998, 11, 16.
  • Paul A. Wender and Paul E. Floreancig, Condensation and Commentary on: "Total Synthesis of (")-Taxusin", CHEMTRACTS--ORGANIC CHEMISTRY, 1998, 11, 16.
  • Paul A. Wender and Daesung Lee, Condensation and Commentary on: "Enantioselective Synthesis of Neocarzinostatin Chromophore Aglycon", CHEMTRACTS--ORGANIC CHEMISTRY, 1997, 10, 653.
  • Wender, P. A.; Handy S. T., Wright D. L. "Towards the Ideal Synthesis" Chemistry & Industry 1997, 765.
  • Wender, P. A.; Badham, N. F.; Conway, S. P.; Floreancig, P. E.; Glass, T. E.; Houze, J. B.; Krauss, N. .E; Lee, D. S.; Marquess, D. G.; Mcgrane, P. L.; Meng, W. "The Pinene Path To Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol" J. Am. Chem. Soc. 1997, 119, 2757-2758. PDF,Supporting Information
  • Wender, P. A.; Rice K. D., Schnute M. E. "The First Formal Asymmetric Synthesis of Phorbol" J. Am. Chem. Soc. 1997, 119, 7897-7898. PDF,Supporting Information
  • Wender, P. A.; Jesudason, C. D.; Nakahira, H.; Tamura, N.; Tebbe, A. L., Ueno, Y. "The First Synthesis of a Daphnane Diterpene: the Enantiocontrolled Total Synthesis of (+)-Resiniferatoxin" J. Am. Chem. Soc. 1997, 119, 12976-12977. PDF, Supporting Information
  • Wender, P. A.; Badham, N. F.; Conway, S. P.; Floreancig, P. E.; Glass T. E.; Granicher, C.; Houze, J. B.; Janichen, J.; Lee, D. S.; Marquess, D. G. "The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor" J. Am. Chem. Soc. 1997, 119, 2755-2756. PDF,Supporting Information
  • Wender, P. A.; Dore, T. M.; deLong, M. A. "An Arene-Alkene Photocycloaddition-Radical Cyclization Cascade: the First Syntheses of Cis,Cis,Cis,Trans-[5.5.5.5]-Fenestranes" Tetrahedon Lett. 1996, 37, 7687-7690. Abstract, PDF
  • Paul A. Wender, et. al., "The Pinene Path to Taxanes: Genesis and Evolution of a Synthesis Strategy",  ACS Symposium Series: Taxane Anticancer Agents: Basic Science and Current Status; G. Georg, T.T. Chan, I. Ojima, D.M. Vyas, Eds.; American Chemical Society, 1995, Series 583, 326-339. Abstract, PDF
  • Wender, P. A.; Natchus, M. G.; Shuker, A. J. "Towards the Total Synthesis of Taxol and its Analogs," in Taxol, Science and Applications; Matthew Suffness, Ed.; CRC Press, Inc, London; Pp. 123-187, 1995.
  • Wender, P. A.; Beckham, S.; Oleary, J. G. "A 2nd-Generation Photochemically Activatable Dynemicin Analog: A Concise Synthesis and DNA Cleavage Studies" Synthesis-Stuttgart 1994, 1278-1282.
  • Paul A. Wender, J. J. Howbert, T. M. Dore, "The Total Synthesis of (±)-a-Cedrene" Photochemical Key Steps in Organic Synthesis Mattay, J.; Griesbeck, A. G., Eds.; VCH Verlagsgesellschaft: Weinheim, Germany; 181-185, 1994.
  • Paul A. Wender, Daniel G. Marquess, P. Leo McGrane and Richard E. Taylor, "Condensation and Commentary on: "First Total Synthesis of Taxol. 1. Functionalization of the B Ring and First Total Synthesis of Taxol. 2. Completion of the C and D Ring" and "Total Synthesis of Taxol"; CHEMTRACTS--ORGANIC CHEMISTRY; 7, 160; 1994.
  • Paul A. Wender, Benjamin L. Miller, "Toward the Ideal Synthesis: Connectivity Analysis and Multi-Bond Forming Processes," In: Organic Synthesis: Theory & Applications, Vol 2; Hudlicky, Thomas, Ed.; JAI; Greenwich, CT; 27-66, 1993.
  • Paul A. Wender and Richard E. Taylor, Condensation and Commentary on: "A One-Step Synthesis of the Ciclamycin 0 Trisaccharide,"CHEMTRACTS--ORGANIC CHEMISTRY; 6, 255, 1993.
  • Wender, P. A.; Mucciaro, T. P. "A New and Practical Approach to the Synthesis of Taxol and Taxol Analogs: The Pinene Path" J. Am. Chem. Soc.1992, 114, 5878-5879. PDF
  • Wender, P. A.; deLong, M. A. "Synthetic Studies on Arene-Olefin Cycloadditions. XII. Total Synthesis of (+/-)-Subergorgic Acid" Tetrahedon Lett.1990, 31, 5429-5432. Abstract, PDF
  • Wender, P. A.; Singh, S. K. "Synthetic Studies on Arene-Olefin Cycloadditions. 11. Total Synthesis of (-)-Retigeranic Acid" Tetrahedon Lett. 1990,31, 2517-2520. Abstract, PDF
  • Wender, P. A.; Ternansky, R; deLong, M; Singh, S; Olivero, A; Rice, K. "Arene Alkene Cycloadditions and Organic-Synthesis" Pure Appl. Chem.1990, 62, 1597-1602.
  • Wender, P. A.; McDonald, F. E. "Studies on Tumor Promoters. 9. A 2nd-Generation Synthesis of Phorbol" J. Am. Chem. Soc. 1990, 112, 4956-4958.PDF
  • Wender, P. A.; Siggel, L.; Nuss, J. M. "Arene-Alkene Photocycloaddition Reaction," Org. Photochem. 10, 357, 1989.
  • Wender, P. A.; Kogen, H.; Lee, H. Y.; Munger, J. D.; Wilhelm, R. S.; Williams, P. D. "Studies on Tumor Promoters. 8. the Synthesis of Phorbol" J. Am. Chem. Soc. 1989, 111, 8957-8958. PDF
  • Wender, P. A.; Ihle, N. C.; Correia C. R. D. "Nickel-Catalyzed Intramolecular [4+4] Cyclo-Additions. 4. Enantioselective Total Synthesis of (+)-Asteriscanolide" J. Am. Chem. Soc. 1988, 110, 5904-5906. PDF
  • Wender, P. A.; Vongeldern, T. W.; Levine, B. H. "Synthetic Studies on Arene Olefin Cyclo-Additions. 10. A Concise, Stereocontrolled Total Synthesis of (+/-)-Laurenene" J. Am. Chem. Soc. 1988, 110, 4858-4860. PDF
  • Wender, P. A.; Harmata, M.; Jeffrey, D.; Mukai, C.; Suffert, J. "Studies on DNA-Active Agents: the Synthesis of the Parent Carbocyclic Subunit of Neocarzinostatin Chromophore-A" Tetrahedon Lett. 1988, 29, 909-912.
  • Paul A. Wender, Konrad F. Koehler, Robert S. Wilhelm, Peter D. Williams, Hee Yoon Lee, "Studies on tumor promoters: the first synthesis of the phorbol skeleton," In Stud. Org. Chem. 25 New Synth. Methodol Functl. Interesting Compd 1987, 163-182, (Amsterdam). PDF
  • Wender, P. A.; Schaus, J. M., White, A. W. "General Methodology for cis-Hydroisoquinoline Synthesis .3. A Sixteen Step Synthesis of Reserpine"Heterocycles 1987, 25, 263-270.
  • Paul A. Wender, Konrad Koehler, Robert Wilhelm, Peter Williams, Richard Keenan, Hee Yoon Lee, "Tumor Promotion: Pharmacological and Synthetic Studies,"in New Synthetic Methodology and Functionally Interesting Compounds, Z-I. Yoshida, Ed.; 1986,  163-184.
  • Wender, P. A.; Fisher, K. "The Total Synthesis of (+/-)-Rudmollin .9. 7-Membered Ring Synthesis Based on Arene Olefin Cycloadditions"Tetrahedon Lett. 1986, 27, 1857-1860.
  • Wender, P. A.; Singh, S. K. "Synthetic Studies on Arene-Olefin Cyclo-Additions .8. Total Syntheses of (+/-)-Silphiperfol-6-Ene, (+/-)-7-Alpha-H-Silphiperfol-5-Ene and (+/-)-7-Beta-H-Silphiperfol-5-Ene" Tetrahedon Lett. 1985, 26, 5987-5990.
  • Wender, P. A.; Holt, D. A. "Macroexpansion Methodology .3. 8-Step Synthesis of (-)-(3Z)-Cembrene-A" J. Am. Chem. Soc. 1985, 107, 7771-7772.PDF
  • Wender, P. A.; Wolanin, D. J. "Total Synthesis of Quadrone and Terrecyclic Acid-A" J. Org. Chem. 1985, 50, 4418-4420. PDF
  • Wender, P. A.; Ternansky R. J. "Synthetic Studies on Arene-Olefin Cyclo-Additions .7. A 3-Step Total Synthesis of (+/-)-Silphinene" Tetrahedon Lett. 1985, 26, 2625-2628.
  • Wender, P. A.; Howbert, J. J. "Synthetic Studies on Areneolefin Cyclo-Additions .6. 2 Syntheses of (+/-)-Coriolin" Tetrahedon Lett. 1983, 24, 5325-5328.
  • Wender, P. A.; Dreyer, G. B. "Synthetic Studies on Arene-Olefin Cyclo-Additions .5. Total Synthesis of (+/-)-Isoiridomyrmecin" Tetrahedon Lett.1983, 24, 4543-4546.
  • Wender, P. A.; Dreyer, G. B."Synthetic Studies on Arene-Olefin Cyclo-Additions .4. Total Synthesis of (+/-)-Modhephene" J. Am. Chem. Soc. 1982,104, 5805-5807. PDF
  • Wender, P. A.; Howbert, J. J. "Synthetic Studies on Arene-Olefin Cyclo-Additions .3. Total Synthesis of +/-Hirsutene" Tetrahedon Lett. 1982, 23, 3983-3986.
  • Wender, P. A.; Eck, S. L."The Olefin Metathesis Trans-Annular Ene Sequence: A Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives .3. Total Synthesis of (+/-)-Warburganal" Tetrahedon Lett. 1982, 23, 1871-1874.
  • Wender, P. A.; Dreyer, G. B. "Synthetic Studies on Arene-Olefin Cyclo-Additions .2. Total Synthesis of (+/-)-Isocomene" Tetrahedron 1981, 37, 4445-4450.
  • Wender, P. A.; Howbert, J. J. "Synthetic Studies on Arene-Olefin Cyclo-Additions: Total Synthesis of (-/+)-Alpha-Cedrene" J. Am. Chem. Soc. 1981,103, 688-690. PDF
  • Wender, P. A.; Lechleiter, J. C. "Total Synthesis of (+/-) Isabelin" J. Am. Chem. Soc. 1980, 102, 6340-6341. PDF
  • Wender, P. A.; Schaus, J. M.; White, A. W. "General Methodology for cis-Hydroisoquinoline Synthesis: Synthesis of Reserpine" J. Am. Chem. Soc.1980, 102, 6157-6159. PDF
  • Wender, P. A.; Letendre, L. J. "Olefin Metathesis Trans-Annular Ene Sequence: Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives .2. Formal Eudesmane Syntheses" J. Org. Chem. 1980, 45, 367-368. PDF
  • Wender, P. A.; Hubbs, J. C. "Olefin Metathesis Trans-Annular Ene Sequence: Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives .1. Total Synthesis of (+/-)-Calameon" J. Org. Chem. 1980, 45, 365-367. PDF
  • Wender, P. A.; Eissenstat, M. A.; Filosa, M. P. "General Methodology for Pseudoguaiane Synthesis: Total Synthesis of (+/-)-Damsinic Acid and (+/-)-Confertin" J. Am. Chem. Soc. 1979, 101, 2196-2198. PDF
  • Wender, P. A.; Lechleiter, J. C. "Photochemically Mediated [4c+2c] Annelation: Synthesis of (+/-)-10-Epijunenol" J. Am. Chem. Soc. 1978, 100, 4321-4322. PDF