Publications by Research Area

New Reactions Development: Metal Catalyzed Cycloadditions
Total Synthesis of Complex Molecules
New Drug Delivery Systems
Drug Design, Synthesis, and Biological Evaluation
Protein Kinase C, Tumor Promotors, and Synthetic Receptors
Other Items and Group History

Representative Publications

  • Sarah A. Overall, Sina J. Hartmann, Quang Luu-Nguyen, Patrick Judge, Dorothea Pinotsi, Lea Marti, Snorri Sigurdsson, Paul A. Wender, Alexander B. Barnes "Topological heterogeneity of protein kinase C modulators in human T-cells resolved with in-cell dynamic nuclear polarization NMR spectroscopy” Journal of the American Chemical Society, 2024, Accepted Abstract, PDF.

  • Harrison P. Rahn, Xinyu Liu, Madeline B. Chosy, Jiuzhi Sun, Lynette Cegelski, Paul A. Wender "Biguanide-Vancomycin Conjugates are Effective Broad-Spectrum Antibiotics against Actively Growing and Biofilm-Associated Gram-Positive and Gram-Negative ESKAPE Pathogens and Mycobacteria” Journal of the American Chemical Society, 2024, 146, 32, 22541-22552. DOI: 10.1021/jacs.4c06520 Abstract, PDF.

  • Shruthi Shanmukha, Wesley H. Godfrey, Payam Gharibani, Judy J. Lee, Yu Guo, Xiaojing Deng, Paul A. Wender, Michael D. Kornberg, Paul M. Kim “TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis” Frontiers in Cellular Neuroscience, 2024, 18: 1373557 Abstract, PDF.

  • Dimapasoc M, Moran JA, Cole SW, Ranjan A, Hourani R, Kim JT, Wender PA, Marsden MD, Zack JA. "Defining the Effects of PKC Modulator HIV Latency-Reversing Agents on Natural Killer Cells" Pathogens and Immunity, 2024, 9(1):108-137, DOI: 10.20411/pai.v9i1.673 Abstract, PDF.

  • Harrison P. Rahn, Jiuzhi Sun, Zhijian Li, Robert M. Waymouth, Ronald Levy, Paul A. Wender "Isoprenoid CARTs: in vitro and in vivo mRNA Delivery by Charge-Altering Releasable Transporters Functionalized with Archaea-inspired Branched Lipids” Biomacromolecules, 2024, 25, 7, 4305-4316. DOI: 10.1021/acs.biomac.4c00373 Abstract, PDF.

  • Zhijian Li, Laura Amaya, Aloysius Ee, Sean Wang, Alok Ranjan, Robert M. Waymouth, Howard Chang, Paul A. Wender “Organ and Cell Selective Delivery of RNA in vivo Using Guanidinylated Serinol Charge-altering Releasable Transporters (GSer-CARTs)” Journal of the American Chemical Society, 2024, 146, 21, 14785-14798. DOI: 10.1021/jacs.4c02704 Abstract, PDF.

  • Chosy, Madeline B.; Sun, Jiuzhi; Rahn, Harrison P.; Brcic, Jasna; Wender, Paul A.; Cegelski, Lynette “Vancomycin-polyguanidino Dendrimer Conjugates Inhibit Growth of Antibiotic-resistant Gram-positive and Gram-negative Bacteria and Eradicate Biofilm-associated S. aureus” ACS Infectious Diseases, 2024, 10, 2, 384-397, DOI: 10.1021/acsinfecdis.3c00168 Abstract, PDF.

  • Jana Blazkova, Emily J Whitehead, Rachel Schneck, Victoria Shi, J Shawn Justement, M Ali Rai, Brooke D Kennedy, Maegan R Manning, Lauren Praiss, Kathleen Gittens, Paul A Wender, Cihan Oguz, Justin Lack, Susan Moir, Tae-Wook Chun “Immunologic and virologic parameters associated with HIV DNA reservoir size in people living with HIV receiving antiretroviral therapy” The Journal of Infectious Diseases, 2024, 229(6):1770-1780, DOI: 10.1093/infdis/jiad595. PMID: 38128541 Abstract, PDF.

  • Zhijian Li, Laura Amaya, Ruoxi Pi, Sean K. Wang, Alok Ranjan, Robert M. Waymouth, Catherine A. Blish, Howard Y. Chang, Paul A. Wender “Charge-altering releasable transporters enhance mRNA delivery in vitro and exhibit in vivo tropism” Nature Communications, 2023, 14, 6983 Abstract, PDF.

  • Jasna Brcic, Alan Tong, Paul A. Wender, Lynette Cegelski “Conjugation of Vancomycin with a Single Arginine Improves Efficacy Against Mycobacteria by More Effective Peptidoglycan Targeting” J. Med. Chem., 2023, 66, 15, 10226-10237, DOI: 10.1021/acs.jmedchem.3c00565 Abstract, PDF.

  • Winkler, Jeffrey D.; Wender, Paul A.; Kahne, Daniel “Gilbert Stork” Biographical Memoir, Proc. Natl. Acad. Sci., 2023, Abstract, PDF.

  • Timothy R. Blake, Ole A. W. Haabeth, Adrienne Sallets, Rebecca L. McClellan, Trevor J. Del Castillo, Jose G. Vilches-Moure, Wilson C. Ho, Paul A. Wender, Ronald Levy, Robert M. Waymouth “Lysine-Derived Charge-Altering Releasable Transporters: Targeted Delivery of mRNA and siRNA to the Lungs” Bioconjugate Chem., 2023, 34, 4, 673-685 DOI: 10.1021/acs.bioconjchem.3c00019 Abstract, PDF.

  • Jose A. Moran, Alok Ranjan, Rami Hourani, Jocelyn T. Kim, Paul A. Wender, Jerome A. Zack, Matthew D. Marsden “Secreted factors induced by PKC modulators do not indirectly cause HIV latency reversal” Virology, 2023, 581:8-14. DOI: 10.1016/j.virol.2023.02.009. PMID: 36842270 Abstract, PDF.

  • Sabrina H. Werby, Jasna Brcic, Madeline B Chosy, Jiuzhi Sun, Jacob T. Rendell, Lewis F. Neville, Paul A. Wender, Lynette Cegelski “Detection of Intact Vancomycin-Arginine as the Active Antibacterial Conjugate in E. coli by Whole Cell Solid-State NMR” RSC Med. Chem., 2023, DOI: 10.1039/D3MD00173C Abstract, PDF.

  • Laura Amaya, Lilit Grigoryan, Zhijian Li, Audrey Lee, Paul A. Wender, Bali Pulendran, Howard Y. Chang “Circular RNA vaccine induces potent T cell responses” PNAS, 2023, 120(20):e2302191120 Abstract, PDF.

  • Brooke D. Kennedy, Jana Blazkova, Jesse S. Justement, Victoria Shi, M. Ali Rai, Maegan R. Manning, Lauren Praiss, Kathleen Gittens, Paul A. Wender, Sean Patro, Xiaolin Wu, Susan Moir, Tae-Wook Chun “Comprehensive analysis of HIV reservoirs in elite controllers” J Clin Invest., 2023, 133(3):e165446 Abstract, PDF.

  • Paul A. Wender, Quang H. Luu-Nguyen, Jack L. Sloane, Alok Ranjan “Trimethylene Methane Dianion Equivalent for the Asymmetric Consecutive Allylation of Aldehydes: Applications to Prins-Driven Macrocyclizations for the Synthesis of Bryostatin 1 and Analogues” Journal of Organic Chemistry, 2022, 87, 15925-15937 Abstract, PDF.

  • Paul A. Wender, Zachary O. Gentry, David J. Fanelli, Quang H. Luu-Nguyen, Owen D. McAteer, Edward Njoo “Practical synthesis of the therapeutic leads tigilanol tiglate and its analogues” Nature Chemistry, 2022, 14, 1421-1426 Abstract, PDF.

  • Robert Chen, Sean K. Wang, Julia A. Belk, Laura Amaya, Zhijian Li, Angel Cardenas, Brian Abe, Chun-Kan Chen, Paul A. Wender, Howard Y. Chang “Engineering circular RNA for enhanced protein production” Nature Biotechnology, 2022, Abstract, PDF.

  • Stefano Testa, Ole A. W. Haabeth, Timothy R. Blake, Trevor J. Del Castillo, Debra K. Czerwinski, Ranjani Rajapaska, Paul A. Wender, Robert M. Waymouth, & Ronald Levy "Fingolimod-conjugated charge-altering releasable transporters efficiently and specifically deliver mRNA to lymphocytes in vivo and in vitro" Biomacromolecules, 2022, 23, 7, 2976-2988 Abstract, PDF.

  • Jocelyn T. Kim, Tian-Hao Zhang, Camille Carmona, Bryanna Lee, Christopher S. Seet, Matthew Kostelny, Nisarg Shah, Hongying Chen, Kylie Farrell, Mohamed S. A. Soliman, Melanie Dimapasoc, Michelle Sinani, Kenia Yazmin Reyna Blanco, David Bojorquez, Hong Jiang, Yuan Shi, Yushen Du, Natalia L. Komarova, Dominik Wodarz, Paul A. Wender, Matthew D. Marsden, Ren Sun & Jerome A. Zack “Latency reversal plus natural killer cells diminish HIV reservoir in vivo” Nature Communications, 2022, 13, 121 Abstract, PDF.

  • Ole A. W. Haabeth, Julian J. K. Lohmeyer, Adrienne Sallets, Timothy R. Blake, Idit Sagiv-Barfi, Debra K. Czerwinski, Blaine McCarthy, Abigail E. Powell, Paul A. Wender, Robert M. Waymouth, and Ronald Levy. “An mRNA SARS-CoV-2 Vaccine Employing Charge-Altering Releasable Transporters with a TLR-9 Agonist Induces Neutralizing Antibodies and T Cell Memory” ACS Cent. Sci., 2021, 7, 7, 1191-1204 Abstract, PDF.

  • Lewis F. Neville, Itamar Shalit, Peter A. Warn, Marc H. Scheetz, Jiuzhi Sun, Madeline B. Chosy, Paul A. Wender, Lynette Cegelski, and Jacob T. Rendell. "In vivo targeting of E. coli with vancomycin-arginine" Antimicrob Agents Chemother, 2021, 65:e02416-20 Abstract, PDF.

  • Efrat Abramson, Clayton Hardman, Akira Shimizu, Soonmyung Hwang, Lynda D. Hester, Solomon H. Snyder, Paul A. Wender, Paul M. Kim, Michael D. Kornberg. "Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation" Cell Chembio, 2021, 28, 4, 537-545 Abstract, PDF.

  • Matthew D. Marsden, Tian-hao Zhang, Yushen Du, Melanie Dimapasoc, Mohamed S. A. Soliman, Xiaomeng Wu, Jocelyn T. Kim, Akira Shimizu, Adam Schrier, Paul A. Wender, Ren Sun, and Jerome A. Zack. "Tracking HIV rebound following latency reversal using barcoded HIV” Cell Reports Medicine, 2020, 1, 9, 100162 Abstract, PDF.

  • Paul A. Wender, Jack L. Sloane, Quang H. Luu-Nguyen, Yasuyuki Ogawa, Akira J. Shimizu, Steven M. Ryckbosch, Jefferson H. Tyler, and Clayton Hardman. “Function Oriented Synthesis: Design, Synthesis, and Evaluation of Highly Simplified Bryostatin Analogs.” Journal of Organic Chemistry, 2020, 85, 23, 15116-15128 Abstract, PDF.

  • Aaron J. Wilk, Nancy L. Weidenbacher, Rosemary Vergara, Ole A.W. Haabeth, Ronald Levy, Robert M. Waymouth, Paul A. Wender, and Catherine A. Blish. “Charge-Altering Releasable Transporters enable Phenotypic Manipulation of Natural Killer Cells for Cancer Immunotherapy” Blood Advances, 2020, 4, 17, 4244-4255 Abstract, PDF.

  • Sarah A. Overall, Lauren E. Price, Brice J. Albert, Chukun Gao, Nicholas Alaniva, Patrick T. Judge, Erika L. Sesti, Paul A. Wender, George B. Kyei, and Alexander B. Barnes. “In situ detection of endogenous HIV activation by dynamic nuclear polarization-NMR and flow cytometry” Int. J. Mol. Sci , 2020, 21, 13, 4649 Abstract.

  • Ly, Calvin; Shimizu, Akira J.; Vargas, Maxemiliano V.; Duim, Whitney C.; Wender, Paul A.; Olson, David E. “Bryostatin 1 Promotes Synaptogenesis and Reduces Dendritic Spine Density in Cortical Cultures through a PKC-Dependent Mechanism” ACS Chemical Neuroscience, 2020, 11, 11, 1545-1554 Abstract, PDF.

  • Jack L. Sloane, Nancy L. Benner, Katherine N. Keenan, Xiaoyu Zang, Mohamed S. A. Soliman, Xiaomeng Wu, Melanie Dimapasoc, Matthew D. Marsden, Jerome A. Zack, and Paul A. Wender “Prodrugs of PKC Modulators Show Enhanced HIV Latency Reversal and an Expanded Therapeutic Window” Proc. Natl. Acad. Sci. USA, 2020, 117, 20, 10688-10698 Abstract, PDF.

  • Clayton Hardman, Stephen Ho, Akira Shimizu, Quang Luu-Nguyen, Jack L. Sloane, Mohamed S. A. Soliman, Matthew D. Marsden, Jerome A. Zack, Paul A. Wender “Design, Synthesis and Evaluation of PKC Modulators for Enhanced Cancer Immunotherapy” Nature Communications, 2020, 11, 1879 Abstract, PDF.

  • Blake, Timothy; Ho, Wilson; Christopher R. Turlington, Xiaoyu Zang, Melanie Huttner, Wender, Paul; Waymouth, Robert “Synthesis and Mechanistic Investigations of pH-Responsive Cationic Poly(aminoester)s” Chemical Science, 2020, 11, 2951-2966. Abstract, PDF.

  • Habibian, Maryam; McKinlay, Colin; Blake, Timothy; Kietrys, Anna; Waymouth, Robert; Wender, Paul; Kool, Eric* “Reversible RNA Acylation for Control of CRISPR-Cas9 Gene Editing”. RSC Chemical Science, 2020, 11, 1011-1016. Abstract, PDF.

  • Jyoti Singh, Alexander Ripp, Thomas M. Haas, Danye Qiu, Manfred Keller, Paul A. Wender, Jay S. Siegel*, Kim K. Baldridge*, Henning J. Jessen* “Synthesis of modified nucleoside oligophosphates simplified: Fast, pure, and protecting group free.” Journal of American Chemical Society, 2019, 141, 38, 15013-15017. Abstract, PDF.

  • Antonoplis, Alexandra; Zang, Xiaoyu; Wegner, Tristan; Wender, Paul; Cegelski, Lynette A Vancomycin-Arginine Conjugate Inhibits Growth of Carbapenem-resistant E. coli and Targets Cell-Wall Synthesis" ACS Chemical Biology, 2019, 14, 9, 2065-2070. Abstract, PDF.

  • Erin D. Huiting, Kathleeen Gittens, J. Shawn Justement, Victoria Shi, Jana Blazkova, Erika Benko, Colin Kovacs, Paul A. Wender, Susan Moir, Michael C. Sneller, Anthony S. Fauci, and Tae-Wook Chun, “Impact of treatment interruption on HIV reservoirs and immune parameters in individuals who had initiated antiretroviral therapy during the early phase of infection”. Journal of Infectious Diseases, 2019, 220 (2), 270-274. Abstract, PDF.

  • Bitnun, Ari; Ransy, Doris G.; Brophy, Jason; Kakkar, Fatima; Hawkes, Micahel; Samson, Lindy; Annabi, Bayader; Pagliuzza, Amelie; Morand, Jacob-Adams; Sauve, Laura; Chomont, Nicolas; Lavoie, Stephanie; Kim, John; Sandstrom, Paul, Wender, Paul A.; Lee, Terry; Singer, Joel; Read, Stanley E.; Soudeyns, Hugo “Clinical correlates of HIV-1 DNA and inducible HIV-1 RNA reservoirs in peripheral blood in children with perinatally acquired HIV-1 infection with sustained virologic suppression for at least 5 years”. Clinical Infectious Diseases, ciz251, published online 28 March 2019, . Abstract, PDF.

  • Nancy L. Benner, Rebecca L. McClellan, Christopher R. Turlington, Ole A Haabeth Robert M. Waymouth, Paul A. Wender “Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery”. Journal of the American Chemical Society, 2019, 141, 21, 8416-8421. Abstract, PDF.

  • Jyoti Singh, Nicole Steck, Debaditya De, Alexandre Hofer, Alexander Ripp, Ilya Captain, Manfred Keller, Paul Wender, Rashna Bhandari, Henning Jacob Jessen, “A phosphoramidite analog of cyclotriphosphateenables iterative polyphosphorylations”. Angew. Chem. Int. Ed., 2019, 58(12), 3928-3933. Abstract, PDF.

  • Ole A. W. Haabeth, Timothy R. Blake, Colin J. McKinlay, Anders A. Tveita, Adrienne Sallets, Robert M. Waymouth, Paul A. Wender and Ronald Levy, “Local delivery of OX40L, CD80, and CD86 mRNA kindles global anti-cancer immunity”. Cancer Research, 2019, 79(7), 1624-1634. Abstract, PDF.

  • Alexandra Antonoplis, Xiaoyu Zang, Melanie A. Huttner, Kelvin K.L. Chong, Yu B. Lee, Julia Y. Co, Manuel R. Amieva, Kimberly A. Kline, Paul A. Wender, Lynette Cegelski, “A dual function antibiotic-transporter conjugate exhibits superior activity in sterilizing MRSA biofilms and killing persister cells”. J. Am. Chem. Soc., 2018, 140, 47, 16140-16151. Abstract, Full Text, PDF.

  • Gabriella M. Fernandes-Cunha, Colin J. McKinlay, Jessica R. Vargas, Henning J. Jessen, Robert M. Waymouth, and Paul A. Wender, “Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters”. ACS Cent. Sci., 2018, 4, 1394-1402. Abstract, Full Text, PDF.

  • Ole A. W. Haabeth, Timothy R. Blake, Colin J. McKinlay, Robert M. Waymouth, Paul A. Wender, and Ronald Levy, “mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice”. Proc. Natl. Acad. Sci. USA, 2018, 115 (39), E9153-E9161. Full Article, PDF.

  • Colin J. McKinlay, Nancy L. Benner, Ole A. Haabeth, Robert M. Waymouth, and Paul A. Wender, “Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters”. Proc. Natl. Acad. Sci. USA, 2018, 115 (26), E5859-E5866. Abstract, Full Text, PDF.

  • Matthew D. Marsden; Xiaomeng Wu; Sara Mottahedan; Brian Loy; Adam J. Schrier; Brian A. DeChristopher; Akira J. Shimizu; Clayton T. Hardman; Stephen Ho; Christina M. Ramirez; Paul A. Wender; Jerome A. Zack; “Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents”. Virology, 2018, 520, 83-93. Abstract, Full Text, PDF.

  • Benner, Nancy; Near, Katherine; Bachmann, Michael; Contag, Christopher; Waymouth, Robert; Wender, Paul; “Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs)”. Biomacromolecules, 2018, 19(7), 2812–2824. Abstract, Full Text, PDF.

  • Hao Yang, Daryl Staveness, Steven M. Ryckbosch, Alison D. Axtman, Brian A. Loy, Alexander B. Barnes, Vijay S. Pande, Jacob Schaefer, Paul A. Wender, Lynette Cegelski, “REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment”. ACS Central Science, 2018, 4(1), 89-96. Abstract, Full Text, PDF.

  • Wender, Paul A.; Ebner, Christian; Fennell, Brandon D.; Inagaki, Fuyuhiko; Schröder, Britte, "Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions”. Org. Lett., 2017, 19(21), 5810-5813. Abstract, Full Text, PDF.

  • Paul A. Wender, Clayton T. Hardman, Stephen Ho, Matthew S. Jeffreys, Ryan V. Quiroz, Steven M. Ryckbosch, Akira J. Shimizu, Jack L. Sloane, Matthew C. Stevens, Jana K. Maclaren, "Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV". Science, 2017, 358, 218-223. Abstract, Full Text, PDF.

  • Matthew D. Marsden, Brian A. Loy, Xiaomeng Wu, Christina M. Ramirez, Adam J. Schrier, Danielle Murray, Akira Shimizu, Steven M. Ryckbosch, Katherine E. Near, Tae-Wook Chun, Paul A. Wender, Jerome A. Zack, "In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication", PLoS Pathogens, September 21, 2017. Full Text, PDF.

  • Liu, Bowen; Ramsundar, Bharath; Kawthekar, Prasad; Shi, Jade; Gomes, Joseph; Luu-Nguyen, Quang; Ho, Stephen; Sloane, Jack; Wender, Paul; Pande, Vijay, "Retrosynthetic reaction prediction using neural sequence-to-sequence models", ACS Central Science, 2017, 358, 218-223. Abstract, Full Text, PDF.

  • Brice Albert, Austin Niu, Rashmi Ramani, Robert M. Williams, Garland R. Marshall, Paul A. Wender, Lee Ratner, Alexander B. Barnes, George B. Kyei, "Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analoges display remarkable potency to activate latent HIV without global T-cell activation", Scientific Reports - Nature, August 7, 2017, 7:7456. Full Text, PDF.

  • Tapan K. Khan, Paul A. Wender, Daniel L. Alkon; "Bryostatin and its synthetic analog rescue dermal fibroblasts from stress and contribute to survival and rejuvenation of human skin equivalents"; J. Cellular Physiology, 2017. Abstract, PDF.

  • Steven M. Ryckbosch, Paul A. Wender, Vijay S. Pande, "Molecular Dynamics Simulations Reveal Ligand-controlled Positioning of a Peripheral Protein Complex in Membranes", Nature Comm.., 2017,8, 6.  Abstract, PDF

  • Nancy L. Benner, Xiaoyu Zang, Daniel C. Buehler, Valerie A. Kickhoefer, Michael E. Rome, Leonard H. Rome, Paul A. Wender, "Vault Nanoparticles: Chemical Modifications for Imaging and Enhanced Delivery", ACS Nano., 2017,11(1), 872-881.  Abstract, PDF, Supporting Information

  • McKinlay, Colin, Waymouth, Robert, Wender, Paul A., "Cell Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery", J.Am.Chem.Soc.., 2016,138(10), 3510-3517.  Abstract, PDF, Supporting Information

  • Colin J. McKinlay, Jessica R. Vargas, Timothy R. Blake, Jonathan W. Hardy, Masamitsu Kanada, Christopher H. Contag, Paul A. Wender, and Robert M. Waymouth, "Charge-altering releasable transporters (CARTS) for the delivery and release of messenger RNA in living animals", Proc. Natl. Acad. Sci.., 2017,114(4), E448-E456.  Abstract, PDF, Supporting Information

  • Rana Abdelnabi, Daryl Staveness, Katherine E. Near, Paul A. Wender, Leen Delang, Johan Neyts, Pieter Leyssen, "Comparative analysis of salicylate-based bryostatin analogs with or without modification at position C26 confirms that the inhibitory effect on chikungunya virus replication also involves a non-PKC-dependent mechanism", Biochemical Pharmacology., 2016, 120, 15-21.  Text, PDF.

  • McKinlay, Colin, Waymouth, Robert, Wender, Paul A., "Cell Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery", J.Am.Chem.Soc.., 2016, 138(10), 3510-3517.  Abstract, PDF, Supporting Information

  • Igor Pavlovic, Divyeshsinh T. Thakor, Jessica R. Vargas, Colin J. McKinlay, Sebastian Hauke, Philipp Anstaett, Rafael C. Camuna, Laurent Bigler, Gilles Gasser, Carsten Shultz, Paul A. Wender, Henning J. Jessen; "Cellular Delivery and Photochemical Release of a Caged Inositol-Pyrophosphate Induces PH-Domain Translocation in Cellulo", Nature Comm., 2016, 7, 10622. Abstract, PDF,  Supporting Information.

  • Hsiao-Tieh Hsu, Brian M. Trantow, Robert M. Waymouth, and Paul A. Wender, "Bioorthogonal Catalysis: A General Method to Evaluate Metal-Catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System", Bioconjugate Chem., 2016, 27(2), 376-382. Abstract, PDF,  Supporting Information.

  • Wender, Paul A.; Jeffreys, Matthew S.; Raub, Andrew G.; "Tetramethyleneethane Equivalents: Recursive Reagents for Serialized Cycloadditions", J. Am. Chem. Soc., 2015, 137(28), 9088-9093. Abstract, PDF,  Supporting Information.

  • Wender, Paul; Quiroz, Ryan; Stevens, Matthew; "Function Through Synthesis-Informed Design", Acc. Chem. Res.; 2015, 48(3), 752-760. Abstract, PDF.

  • Loy Brian A., Lesser Adam B., Staveness Daryl, Billingsley Kelvin L., Cegelski Lynette, Wender Paul A., "Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy", J Am Chem Soc., 2015, 137(10), 3678-3685. Abstract, PDF, Supporting Information.

  • Wender, Paul A.; Fournogerakis, Dennis N.; Jeffreys, Matthew S.; Quiroz, Ryan V.; Inagaki, Fuyuhiko; Pfaffenbach, Magnus; "Structural Complexity Through Multicomponent Cycloaddition Cascades Enabled by Dual-Purpose, Reactivity Regenerating 1,2,3-Triene Equivalents", Nature Chemistry, 2014, 6, 448-452. Abstract, PDF.

  • Wender, P.A.; Donnelly, A.C.; Loy, B.A.; Near, K.E.; Staveness, D., “Rethinking the Role of Natural Products: Function-Oriented Synthesis, Bryostatin and Bryologs;Natural Products in Medicinal Chemistry (Ed: S. Hanessian) Wiley-VCH, 2014, Ch. 14, 475-544. PDF.

  • Vargas, Jessica R.; Geihe Stanzl, Erika; Teng, Nelson N.H.; Wender, Paul A.; "Cell-penetrating, Guanidinium-rich Molecular Transporters for Overcoming Efflux-mediated Multidrug Resistance", Molecular Pharmaceutics, 2014, 11(8), 2553-2565.  Abstract, PDF

  • Erika Geihe Stanzl, Brian M. Trantow, Jessica R. Vargas, Paul A. Wender, "15 Years of Cell-Penetrating, Guanidinium-rich Molecular Transporters: Basic Science, Research Tools and Clinical Applications", Accounts, 2013, 46(12), 2944-2954. Abstract, PDF.

  • Wender, Paul A. "Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis", Tetrahedron, 2013, Vol. 69, Issue 36, 7529-7550. Abstract.

  • Elizabeth J. Beans, Dennis Fournogerakis, Carolyn Gauntlett, Lars V. Heumann, Rainer Kramer, Matthew D. Marsden, Danielle Murray, Tae-Wook Chun, Jerome A. Zack, and Paul A. Wender, "Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo", PNAS, 2013, 110(29), 11698-11703. Abstract, PDF.

  • Brian A. DeChristopher, Brian A. Loy, Matthew D. Marsden, Adam J. Schrier, Jerome A. Zack, & Paul A. Wender, “Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro”, Nature Chemistry, 2012, 4, 705-710. Full Text.

  • Erika I. Geihe, Christina B. Cooley, Jeff R. Simon, Matthew K. Kiesewetter, Justin A. Edward, Robyn P. Hickerson, Roger L. Kaspar, James L. Hedrick, Robert M. Waymouth, & Paul A. Wender, “Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells”, PNAS, 2012, 109 (33), 13171-13176. Abstract, PDF, Supporting Information.

  • Paul Wender & Adam Schrier; "Total Synthesis of Bryostatin 9", Journal of the American Chemical Society, 2011, 133(24), 9228-9231. Abstract, PDF.

  • Wender, Paul A.; Miller, Benjamin L.; "Synthesis at the Molecular Frontier", Nature, 2009, 460, 197-201. Abstract, PDF.

  • Paul A. Wender, Jung-Min Kee, and Jeffrey M. Warrington, "Practical Synthesis of Prostratin, DPP, and their Analog, Adjuvant Against Latent HIV", Science, 2008, 320, 649-652. Abstract, HTML, Supporting Information.