New Drug Delivery Systems
Previous   Next

  • Ole Audun Werner Haabeth, Timothy R. Blake, Colin J. McKinlay, Anders A. Tveita, Adrienne Sallets, Robert M. Waymouth, Paul A. Wender and Ronald Levy, “Local delivery of OX40L, CD80, and CD86 mRNA kindles global anti-cancer immunity”. Cancer Research, 2019, ACCEPTED Abstract, PDF.
  • Alexandra Antonoplis, Xiaoyu Zang, Melanie A. Huttner, Kelvin K.L. Chong, Yu B. Lee, Julia Y. Co, Manuel R. Amieva, Kimberly A. Kline, Paul A. Wender, Lynette Cegelski, “A dual function antibiotic-transporter conjugate exhibits superior activity in sterilizing MRSA biofilms and killing persister cells”. J. Am. Chem. Soc., 2018, 140, 47, 16140-16151. Abstract, Full Text, PDF.
  • Gabriella M. Fernandes-Cunha, Colin J. McKinlay, Jessica R. Vargas, Henning J. Jessen, Robert M. Waymouth, and Paul A. Wender, “Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters”. ACS Cent. Sci., 2018, 4, 1394-1402. Abstract, Full Text, PDF.
  • Ole A. W. Haabeth, Timothy R. Blake, Colin J. McKinlay, Robert M. Waymouth, Paul A. Wender, and Ronald Levy, “mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice”. Proc. Natl. Acad. Sci. USA, 2018, 11539, E9153-E9161. Full Article, PDF.
  • Colin J. McKinlay, Nancy L. Benner, Ole A. Haabeth, Robert M. Waymouth, and Paul A. Wender, “Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters”. Proc. Natl. Acad. Sci. USA, 2018, 11526, E5859-E5866. Abstract, Full Text, PDF.
  • Benner, Nancy; Near, Katherine; Bachmann, Michael; Contag, Christopher; Waymouth, Robert; Wender, Paul; “Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs)”. Biomacromolecules, 2018, 19(7), 2812–2824. Abstract, Full Text, PDF.
  • Nancy L. Benner, Xiaoyu Zang, Daniel C. Buehler, Valerie A. Kickhoefer, Michael E. Rome, Leonard H. Rome, Paul A. Wender, "Vault Nanoparticles: Chemical Modifications for Imaging and Enhanced Delivery", ACS Nano., 2017,11(1), 872-881.  Abstract, PDF, Supporting Information
  • Colin J. McKinlay, Jessica R. Vargas, Timothy R. Blake, Jonathan W. Hardy, Masamitsu Kanada, Christopher H. Contag, Paul A. Wender, and Robert M. Waymouth, "Charge-altering releasable transporters (CARTS) for the delivery and release of messenger RNA in living animals", Proc. Natl. Acad. Sci.., 2017,114(4), E448-E456.  Abstract, PDF, Supporting Information
  • McKinlay, Colin, Waymouth, Robert, Wender, Paul A., "Cell Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery", J.Am.Chem.Soc.., 2016,138(10), 3510-3517.  Abstract, PDF, Supporting Information
  • Hsu, H.-T.; Trantow, B.M.; Waymouth, R.M.; Wender, P.A., "Bioorthogonal Catalysis: A General Method To Evaluate Metal-Catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System", Bioconjugate Chem. ., 2016,27(2), 376-382.  Abstract, PDF, Supporting Information
  • Pavlovic, I.; Thakor, D. T.; Vargas, J. R.; McKinlay, C. J.; Hauke, S.; Anstaett, P.; Camuña, R. C.; Bigler, L.; Gasser, G.; Schultz, C.; Wender, P. A.; Jessen, H. J., "Cellular Delivery and Photochemical Release of a Caged Inositol-Pyrophosphate Induces PH-Domain Translocation in Cellulo", Nature Communications., 2016, 7, 10622.  Abstract, PDF
  • Wender, P.A.; Huttner, M.A.; Staveness, D.; Vargas, J.R.; Xu, A.F., "Guanidinium-Rich, Glycerol-Derived Oligocarbonates: A New Class of Cell-Penetrating Molecular Transporters That Complex, Deliver, and Release siRNA", Mol. Pharmaceutics., 2015, 12(3), 742-750.  Abstract, PDF, Supporting Information
  • Daniel C. Buehler, Matthew D. Marsden, Sean Shen, Daniel B. Toso, Xiaomeng Wu, Joseph A. Loo, Z. Hong Zhou, Valerie A. Kickhoefer, Paul A. Wender, Jerome A. Zack, and Leonard H. Rome, "Bioengineered vaults: Self-assembling protein shell-lipophilic core nanopartiles for drug delivery", ACS Nano., 2014, 8(8), 7723-7732.  Abstract, PDF
  • Vargas, Jessica R.; Geihe Stanzl, Erika; Teng, Nelson N.H.; Wender, Paul A.; "Cell-penetrating, Guanidinium-rich Molecular Transporters for Overcoming Efflux-mediated Multidrug Resistance", Molecular Pharmaceutics, 2014, 11(8), 2553-2565.  Abstract, PDF
  • Erika G. Stanzl, Brian M. Trantow, Jessica R. Vargas & Paul A. Wender; "Fifteen Years of Cell-Penetrating, Guanidinium-Rich Molecular Transporters: Basic Science, Research Tools, and Clinical Applications", Acc. Chem Res., 2013, 46(12), 2944-2954.  Abstract, PDF
  • Wender, P.A.; Cooley, C.B.; Geihe, E.I., "Beyond Cell Penetrating Peptides: Designed Molecular Transporters", Drug Discovery Today: Tech. 2012,9, e49-e55. PDF
  • Erika I. Geihe, Christina B. Cooley, Jeff R. Simon, Matthew K. Kiesewetter, Justin A. Edward, Robyn P. Hickerson, Roger L. Kaspar, James L. Hedrick, Robert M. Waymouth, & Paul A. Wender, “Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells”, PNAS, 2012, 109 (33), 13171-13176. Abstract, PDF, Supporting Information.
  • Joel M. Hyman, Erika I. Geihe, Brian M. Trantow, Bahram Parvin, & Paul A. Wender; “A molecular method for the delivery of small molecules and proteins across the cell wall of algae using molecular transporters”, PNAS, 2012, 109 (33), 13225-13230. Abstract, PDF, Supporting Information.
  • Paul A. Wender, PhD; Wesley C. Galliher, PhD; Neelima M. Bhat, PhD; Thomas H. Pillow, PhD; Marcia M. Bieber, MD; Nelson N.H. Teng, M.D., PhD; "Taxol-Oligoarginine Conjugates Overcome Drug Resistance in-vitro in Human Ovarian Carcinoma";Gynecologic Oncology, 2012, 126, 118-123.Article.
  • Jana Blazkova, Tae-Wook Chun, Bietel W. Belay, Danielle Murray, J. Shawn Justement, Emily K. Funk, Amy Nelson, Claire W. Hallahan, Susan Moir, Paul A. Wender, and Anthony S. Fauci; "Effect of Histone Deacetylase Inhibitors on HIV Production in Latently Infected, resting CD4+T Cells from Infected Individuals Receiving Effective Antiretroviral Therapy";J. Infectious Diseases, 2012, 206(5), 765-769.Article, PDF.
  • Christina B. Cooley, Brian M. Trantow, Fredrik Nederberg, Matthew K. Kiesewetter, James L. Hedrick, Robert M. Waymouth, Paul A. Wender “Oligocarbonate Molecular Transporters: Oligomerization Based Syntheses and Cell Penetrating Studies” JACS, 2009, 131(45), 16401-16403.Abstract, PDF, Supporting Information.
  • Dubikovskaya, E.A.; Thorne, S.H.; Pillow, T.H.; Contag, C.H.; Wender, P.A., "Overcoming Multidrug Resistance of Small-Molecule Therapeutics Through Conjugation with Releasable Octaarginine Transporters." Proc. Natl. Acad. Sci. USA 2008, 105, 12128. Abstract, PDF, Supporting Information.
  • Lee, H.L.; Dubikovskaya, E.A.; Hwang, H.; Semyonov, A.N.; Wang, H.; Jones, L.R.; Tweig, R.J.; Moerner, W.E.; Wender, P.A. "Single-Molecule Motions of Oligoarginine Conjugates on the Plasma Membrane of Chinese Hamster Ovary Cells." J. Am. Chem. Soc. USA 2008, 130, 9364. Abstract, PDF, Supporting Information.
  • Wender, P.; Galliher, W.; Goun, E.; Jones, L.; Pillow, T.  “The Design of Guanidinium-rich Transporters and Their Internalization Mechanisms”  Adv. Drug Delivery Rev. 2008, 60, 452. Abstract, PDF.
  • Paul A. Wender, Jung-Min Kee, and Jeffrey M. Warrington, "Practical Synthesis of Prostratin, DPP, and their Analog, Adjuvant Against Latent HIV",Science, 2008, 320, 649-652. Abstract, HTML, Supporting Information.
  • Wender, P. A.; Goun, E. A.; Jones, L. R.; Pillow, T. H.; Rothbard, J. B.; Shinde, R.; Contag, C. H. "Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice" Proc. Natl. Acad. Sci. USA 2007, 104, 10340-10345. Abstract, PDF,Supporting Information.
  • Rothbard, Jonathan B.; Jessop, Theordore C.; Wender, Paul A.; "Molecular Understanding of Cellular Uptake by Arginine-Rich Cell Penetrating Peptides" Polymeric Drug Delivery 1 (ACS Symposium Series 923)  Chapter 12, 2006,  166-181. Abstract, PDF,
  • Goun, E. A.; Pillow, T. H.; Jones, L. R.; Rothbard, J. B.; Wender, P. A.; "Molecular Transporters: Synthesis of Oligoguanidinium Transporters and Their Application to Drug Delivery and Real-Time Imaging" ChemBioChem 2006, 7, 1497-1515. Abstract, PDF,
  • Goun, E. A.; Shinde, R.; Dehnert, K. W.; Adams-Bond, A.; Wender, P. A.; Contag, C. H.; Franc, B. L. "Intracellular Cargo Delivery by an Octaarginine Transporter Adapted to Target Prostate Cancer Cells through Cell Surface Protease Activation" Bioconjugate Chem. 2006, 17(3), 787-796. Abstract, PDF,
  • Jones, L. R.; Goun, E. A.; Shinde, R.; Rothbard, J. B.; Contag, C. H.; Wender, P. A. "Releasable Luciferin-Transporter Conjugates: Tools for the Real-Time Analysis of Cellular Uptake and Release" J. Am. Chem. Soc. 2006, 128, 6526-6527. Abstract, PDF, Supporting Information.
  • Wender, P. A.; Kreider, E.; Pelkey, E. T.; Rothbard, J.; VanDeusen, C. L. "Dendrimeric Molecular Transporters: Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake" Org. Lett. 2005, 7, 4815-4818. Abstract, PDF, Supporting Information.
  • Rothbard, J. B.; Jessop, T. C.; Wender, P. A. "Adaptive Translocation: The Role of Hydrogen Bonding and Membrane Potential in the Uptake of Guanidinium-rich Transporters into Cells" Adv. Drug Delivery Rev. 2005, 57, 495-504. Abstract.
  • Rothbard, J. B.; Jessop, T. C.; Lewis, R. S.; Murray, B. A.; Wender, P. A. "Role of Membrane Potential and Hydrogen Bonding in the Mechanism of Translocation of Guanidinium-Rich Peptides into Cells" J. Am. Chem. Soc. 2004, 126, 9506-9507. Abstract, PDF, Supporting Information.
  • Kam, N. W. S.; Jessop, T. C.; Wender, P. A.; Dai, H. "Nanotube Molecular Transporters: Internalization of Carbon Nanotube-Protein Conjugates into Mammalian Cells" J. Am. Chem. Soc. 2004, 126, 6850-6851. Abstract, PDF, Supporting Information.
  • Kirschberg, T. A.; VanDeusen, C. L.; Rothbard, J. B.; Yang, M.; Wender, P. A.. "Arginine-Based Molecular Transporters: The Synthesis and Chemical Evaluation of Releasable Taxol-Transporter Conjugates" Org. Lett. 2003, 5, 3459-3462. Abstract, PDF, Supporting Information.
  • Rothbard, J.; Wender, P. A.; Lewis, R. S. "Transepithelial Delivery of Therapeutics Mediated by Polyguanidyl Compounds" Polymeric Mat. Sci. Eng.2003, 89, 108.
  • Franc, B. L.; Mandl, S. J.; Siprashvili, Z.; Wender, P. A.; Contag, C. H. "Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy" Mol. Imag. 2003, 2, 313-323.
  • Siprashvili, Z; Scholl, F. A.; Oliver, S. F.; Adams, A.; Contag, C. H.; Wender, P. A.; Khavari, P. A. "Gene Transfer via Reversible Plasmid Condensation with Cysteine-flanked, Internally Spaced Arginine-rich Peptides" Human Gene Therapy, 2003, 14, 1225-1233.
  • Wright, L. R.; Rothbard, J. B.; Wender, P. A. "Guanidinium Rich Peptide Transporters and Drug Delivery" Current Protein & Peptide Sci., 2003, 4, 105-124.
  • Wender, P. A.; Baryza, J. L.; Brenner, S. E.; Clarke, M. O.; Gamber, G. G.; Horan, J. C.; Jessop, T. C.; Kan, C.; Pattabiraman, K.; Williams, T. J. "Inspirations from Nature. New Reactions, New Therapeutic Leads, and New Drug Delivery Systems" Pure Appl. Chem., 2003, 75, 143-156.Abstract.
  • Samuel, B. U.; Hearn, B.; Mack, D.; Wender, P.; Rothbard, J.; Kirisits, M. J.; Mui, E.; Wernimont, S.; Roberts, C. W.; Muench, S. P.; Rice, D. W.; Prigge, S. T.; Law, A. B.; McLeod, R. "Delivery of Antimicrobials into Parasites" Proc. Natl. Acad. Sci. USA, 2003, 100, 14281-14286. Abstract,PDF, Supporting Information.
  • Wender, P. A.; Rothbard, J. B.; Jessop, T. C.; Kreider, E. L.; Wylie, B. L. "Oligocarbamate Molecular Transporters: Design, Synthesis, and Biological Evaluation of a New Class of Transporters for Drug Delivery" J. Am. Chem. Soc. 2002, 124, 13382-13383. Abstract, PDF, Supporting Information. This was selected as a Science Editors' Choice.
  • Rothbard, J. B.; Kreider, E.; Pattabiraman, K.; Pelkey, E. T.; VanDeusen, C. L.; Wright, L.; Wylie, B. L.; Wender, P. A. "Arginine-Rich Molecular Transporters for Drugs: The Role of Backbone and Sidechain Variations on Cellular Uptake", In Cell-Penetrating Peptides: Processes and Applications, Ulo Langel, Ed.; CRC Press, Boca Raton, Fla, 141-160, 2002.
  • Robbins, P. B.; Oliver, S. F; Sheu, S. M.; Goodnough, J. B.; Wender, P. A.; Khavari,P. A. "Peptide Delivery to Tissue via reversibly Linked Protein transduction Sequences" BioTechniques, 2002, 33, 190-194. PDF
  • Rothbard, J.B.; Kreider, E.; VanDeusen, C.L.; Wright, L.; Wylie, B.L.; Wender, P. A. "Arginine-Rich Molecular Transporters for Drug Delivery: Role of Backbone Spacing in Cellular Uptake" J. Med. Chem. 2002, 3612-3618. Abstract, PDF
  • Paul A. Wender, Theodore C. Jessop, Kanaka Pattabiraman, Erin T. Pelkey, Chris L. VanDeusen; "Cooperative chemical sensing with bis-tritylacetylenes: pinwheels receptors with metal ion recognition properties"; Chemtracts 2001, 14(4), 18-189.
  • Robbins, P.B.; Rothbard, J.B.; Sheu, S.M.; Oliver, S.F.; Goodnough J.B.; Wender, P.A.; and Khavari, P.A.; "Molecular transporters facilitate topical protein transduction into the skin" J. Invest. Dermatol. 2001, 117, 549.
  • Wender, P. A.; Jessop, T. C.; Pattabiraman, K.; Pelkey, E. T.; VanDeusen, C. L. "An Efficient, Scalable Synthesis of the Molecular Transporter Octaarginine Via a Segment Doubling Strategy" Org. Lett. 2001, 3, 3229-3232. Abstract, PDF, Supporting Information
  • Chen, L; Wright, L. R.; Chen, C. H.; Oliver, S. F.; Wender, P. A.; Mochly-Rosen D. "Molecular Transporters for Peptides: Delivery of a Cardioprotective Epsilon PKC Agonist Peptide into Cells and Intact Ischemic Heart Using a Transport System, R-7" Chemistry & Biology 2001, 8, 1123-1129. Abstract, PDF
  • Wender, P. A.; Mitchell, D. J.; Pattabiraman, K.; Pelkey, E. T.; Steinman, L.; Rothbard, J. B. "The Design, Synthesis, and Evaluation of Molecules That Enable or Enhance Cellular Uptake: Peptoid Molecular Transporters" Proc. Natl. Acad. Sci. U. S. A. 2000, 97, 13003-13008. Abstract, PDF
  • Rothbard J. B.; Garlington, S.; Lin, Q.; Kirschberg, T.; Kreider, E.; McGrane, P. L.; Wender, P. A.; Khavari. P. A. "Conjugation of Arginine Oligomers to Cyclosporin A Facilitates Topical Delivery and inhibition of inflammation" Nature Medicine 2000, 6, 1253-1257. Abstract, PDF