Gene |
Natural Allele |
Phenotype
of Knockouts or Other Functions |
- Wnt1
- (previously called int-1)
|
- swaying
- Thomas,
1991
|
|
- Wnt2
- (previously called irp)
|
|
|
Wnt2b/13 |
|
|
Wnt3 |
|
|
Wnt3a |
- vestigial
- tail Greco
1996
|
- somites, tailbud defects (Takada,
1994 Greco
1996 Yoshikawa
Y, 1997 ) through loss expression Brachyury (Yamaguchi
et al, 1999) This is mediated by Lef-1 (Galceran,
2001)
- deficiency in neural crest derivatives, reduction in
dorsolateral neural precursors in the neural tube together with Wnt-1
KO Ikeya
M, et al.
- Loss hippocampus (Lee
et al, 2000)
- Segmentation oscillation clock (Aulehla
2003)
- Left right asymmetry (Nakaya
2005)
- HSC self-renewal defect (Luis,
2008)
- Hindgut extension, Colon formation (Garriock et al, 2020)
|
Wnt4 |
|
|
Wnt5a |
|
- truncated limbs, truncated AP axis, reduced number
proliferating cells Yamaguchi
1999
- Distal lung morphogenesis (Li,
2002)
- Chondrocyte differentiation, longitudinal skeletal
outgrowth (Yang,
2003)
- Inhibits B cell proliferation and functions as a tumor
suppressor (Liang
2003)
- Defects in posterior growth of the female reproductuve
tract (Mericskay
et al, 2004)
- shortened and widened cochlea (planar polarity) Qian
2007
- Mammary gland phenotype (Roarty,
2007)
- prostate gland development Huang
2009
- intestinal elongation Cervantes,
2009
- endothelial differentiation of ES cells Yang,
2009
- Post-mitotic Filopodial Pathfinding (Wang et al, 2018)
|
Wnt5b |
|
|
Wnt6 |
|
|
Wnt7a |
- postaxial hemimelia
- Parr
1998
|
- limb polarity (Parr
1995)
- female infertility; failure regression of the Mullerian
duct because the receptor for Mullerian-inhibiting substance is not
expressed.
Parr 1998
- maintenance appropriate uterine patterning during the
development of the mouse female reproductive tract (Miller
1998)
- Delayed maturation synapses in Cerebellum (Hall,
2000)
- High levels cell death in response to DES in the Female
Reproductive Tract (Carta
L, Sassoon D, 2004)
- May promote neuronal differentiation (Hirabayashi
2004)
- CNS vasculature (with Wnt7b, Stenman
2008)
|
Wnt7b |
|
|
Wnt8a |
|
|
Wnt8b |
|
- Â Loss of function mutant: no effect on neural
development, but changes in gene expression. (Fotaki,
2009)
|
Wnt9a
(prev. Wnt14)
|
|
|
Wnt9b
(prev. Wnt15)
|
|
|
Wnt10a |
|
|
Wnt10b |
|
|
Wnt11 |
|
|
Wnt16 |
|
|