Wnt in Human Genetic DiseasesWnt in MouseWnt in FlyWnt in ZebrafishWnt in Cancer

Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during development and adult tissue homeostasis. Wnt signaling is often implicated in stem cell control, as a self-renewal signal. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. Insights into the mechanisms of Wnt action have emerged from several systems: genetics in Drosophila and Caenorhabditis elegans; biochemistry in cell culture and ectopic gene expression in Xenopus embryos.  As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. Through several cytoplasmic relay components, the signal is transduced to ß-catenin, which enters the nucleus and forms a complex with TCF to activate transcription of Wnt target genes.

This website serves as a resource for members of the Wnt community, providing information on progress in the field, maps on signaling pathways, and methods. The page on reagents lists many resources generously made available to and by the Wnt community.

Wnt signaling is discussed in many reviews, listed here, including a review on the history of the field. New reviews, September 2016.

Wnt meetings are announced here. In 2017, there will be a Wnt Gordon conference,   August 6 - 11, 2017 at the Stoweflake Conference Center, Stowe, VT

Wnt signaling components

Wnt proteins and genes 

Frizzled, SFRP




Other receptors/LRP




Other genes

Wnt Target genes

Diseases/Other systems

Methods, Reagents


Diagrams of Wnt signaling events


Wnt signaling (overview)

wnt secretion

Wnt secretion


Wnt receptors


destruction complex


The destruction complex (new, 2016)


Nuclear events


Wnt signaling in cancer

protein interactions

Protein interactions 

Have a question about Wnt? Consult the Wnt community on LinkedIn® 

Wnt Signaling DiagramProtein InteractionsWnt in CancerTwo-state modelWnt-Hedgehog ComparisonMultiple Wnt Receptors