Syntenic Vertebrate Wnt genes
There are several cases of closely linked and syntenic Wnt genes in the human and mouse genomes, listed here. Some of the Drosophila orthologs, wingless, DWnt10 and DWnt6, are also linked. See (Nusse, 2001; PDF) for a discussion of the evolutionary implications.
Note that in Drosophila, wingless, DWnt10 and DWnt6 are immediately adjacent, while DWnt4 (the ortholog of Wnt9; Qian et al (2003) ) is very close to that cluster.
|
. |
|
Drosophila |
|---|---|---|---|
| 12q13 | Wnt1 | 15 56.8 | wingless |
| 12q13 | Wnt10B | 15 56.8 | DWnt10 |
| 2q35 | Wnt10A | 1 | |
| 2q35 | Wnt6 | 1 | DWnt6 |
| 17q21 | Wnt3 | 11 63 | no orthol. |
| 17q21 | Wnt9B | 11 63 | DWnt4 |
| 1q42 | Wnt9A | 11 32 | |
| 1q42 | Wnt3A | 11 32 | no orthol. |
| 7q31 | Wnt2 | 6 | no orthol. |
| 7q31 | Wnt16 | 6 | no orthol. |
| unlinked | |||
| 1p13 | Wnt2B | 3 | no orthol. |
| 1p36 | Wnt4 | 4 | no orthol. |
| 3p21.2 | Wnt5A | 14 | DWnt5 |
| 12p13 | Wnt5B | 6 | |
| 3p25 | Wnt7A | 6 | DWnt2 |
| 22q13 | Wnt7B | 15 | |
| 5 | Wnt8A | 18 | no orthol. |
| 10q24 | Wnt8B | 19 | no orthol. |
| 11q13 | Wnt11 | 7 | no orthol. |
|
no ortholog
|
WntD | ||
