Problem Sets (20%)
Problem set 1. Out April 4. Due April 18.
Problem set 2. Out April 18. Due May 2.
Choose one of the following projects. Email firstname.lastname@example.org by April 16 with your choice.
a. One page write up of association of how a SNP is linked with a particular trait. The format is the same as used at SNPedia.com. For example, see http://www.snpedia.com/index.php/Rs1800497. This should be a new SNP, not currently listed at DTC companies or on SNPedia. (Previous traits can be written with permission from Stuart Kim and your write up has to be significantly different than ones available on the web. )
b. First draft due on May 16, 2013.
c. We will post your write up and allow students to look up their SNPs from your write up. The class can comment on your write up.
d. Qualified write-ups will be published on SNPedia.com on week 10.
2. Special Project
In the past, some students have found a specific interest in some aspect of Personalized Medicine. This may come from your interest in some aspect of your own genetics, the ethics of genetic testing, or entrepreneurial possibilities in Personalized Medicine. You may come up with an individualized project for class credit by discussing your idea with one of the course directors. Examples include:
a. Participate in an ethics debate on 4/23/2013.
b. Give a 15' presentation to the class about some genetic trait. There is limited class time so there must be a specific reason why you should give a class presentation rather than do the write-up.
c. Write a 5 page proposal of specific aims for this RFA:
National Human Genome Research Institute (NHGRI)
Genomic Medicine Pilot Demonstration Projects (U01)
Amount of funding: $750,000 total costs plus indirects per year x 4 yrs
Purpose: The purpose of this funding opportunity announcement (FOA) is to support a consortium of collaborative Genomic Medicine Pilot Demonstration Projects designed to develop methods for, and evaluate the feasibility of, incorporating an individual patient’s genomic findings into his or her clinical care.
Final Exam (40% credit) take home.
- Scenario is that you are an MD diagnosing a patient.
You will be given the genotypes of a hypothetical family. The final will have various scenarios.
You need to discuss how the genotype of the patient affects the diagnosis of the patient. You will use the tools from the class website to analyze the patient's genome, and provide informative feedback to the patient.
Extra credit. (10%)
a. You will be given the genotypes of 7 people (SK, KK, RT, NT, NZ, MPS, GC).
b. You will be told ancestry and specific traits for these 7 people.
c. You need to match the genotype with the person.
In the past, some students have taken this introductory class even though they are highly advanced in human genetics and bioinformatics. These students can do a more advanced project by consulting one of the course instructors. Students that undertake a super-project do not need to take the final exam. Possible super-projects topics include:
a. Annotate whole-genome sequence for Stuart Kim or Aaron Gitler (adopted).
b. Write a grant for Kaiser-Permanente GWAS (n=110,000 patients)
c. Analyze exome sequence data from ALS patients
d. Write an algorithm for choosing minimal n number of people to sequence to get all sequence data in a population