Nam-Joon Cho's

W.J. Lee, N.J. Cho, A. Xiong, J.S. Glenn, C.W. Frank.
"Hydrophobic nanoparticles
improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while
maintaining patternability." Proceedings of the National Academy of
Science. 2010. Accepted. Ph.D. mentoring project,
N.J. Cho, and C.W. Frank. "Novel strategy to form a
planar lipid bilayer on titanium oxide" Langmuir. 2010, In press.
N.J. Cho*, C.W. Frank, B. Kasemo, F. Hook* "Quartz crystal
microbalance with dissipation monitoring of supported lipid bilayers on various
substrates"
Nature
Protocols. 2010. 5, pp. 1096-106. *Denotes Shared Corresponding
Authorship
* Highlighted as cover image on Nature Protocols website
from May 27th to June 3rd
N.J. Cho, H. Dvory-Sobol,
C.H. Lee, S.J. Cho, J.S. Glenn. "Identification of a novel class of HCV inhibitors directed
against the nonstructural protein NS4B". Jan 20; 2(15), Science Translational
Medicine. 2010
* Highlighted by leading international news
organizations including Reuters, BusinessWeek, MSN Health Yahoo News, and The
Independent (UK) as well as the Stanford University website homepage
Reuters,
Team finds potential path for Hepatitis C drugs
CNBC, Team finds potential
path for Hepatitis C drugs
BusinessWeek,
New treatment eyed for Hepatitis C
ScienceDaily,
Potential new class of drugs to combat Hepatitis C identified
EurekAlert,
Potential new class of drugs to combat Hepatitis C identified
The
Independent (UK), New research finds promising treatment for
hepatitis C
Yahoo
News, Team finds potential path for Hepatitis C drugs
MSN
Health, New treatment eyed for Hepatitis C
Health
Day News, New treatment eyed for Hepatitis C
eScience
News, Potential new class of drugs to combat hepatitis C identified
by Stanford scientists
Inside Stanford
Medicine, Potential new class of drugs to combat Hepatitis C
identified by scientists, (Stanford University Cover)
C.J.
Huang*, N.J. Cho*, C.J Hsu*, P.Y. Tseng, C.W. Frank, Y.C. Chang.
"Type I
collagen-functionalized supported lipid bilayer as a cell culture
platform". Submitted. 2010. *Denotes Shared First
Authorship
J.A. Jackman, N.J. Cho,
R.S. Duran, C.W. Frank. "Interfacial binding dynamics of bee venom phospholipase A2
investigated by dynamic light scattering and quartz crystal
microbalance". Langmuir. 2010 Mar 16; 26(6): 4103-12.
Undergraduate mentoring project
P.D. Bryson, 87(1): 1-8.
N.J. Cho, S. Einav, C.H. Lee, V. Tai, J. Bechtel, M. Sivaraja, C.
Roberts, U. Schmitz, J.S. Glenn. "A small molecule inhibits HCV replication and disrupts NS4B
subcellular localization". Antiviral Research. 2010
N.J.
Cho, H. Dvory-Sobol, A. Xiong, C.W. Frank, J.S. Glenn. "The mechanism of an
amphipathic a-helical peptide's antiviral activity involves size-dependent virus
particle lysis". Dec 18; 4(12): 1061-7, ACS Chemical
Biology, 2009.
W.J. Lee, M. Wiseman, N.J.
Cho, J.S. Glenn, C.W. Frank. "The reliable targeting of specific drug release profiles by
integrating arrays of different albumin-encapsulated microsphere
types".
Biomaterials 2009 Dec; 30(34): 6648-54. Ph.D. mentoring
project
N.J. Cho, C.H. Lee, P.S. Pang, J.S. Glenn.
"Phosphatidylinositol
4,5-bisphosphate is a ligand of HCV NS5A and mediates viral genome
replication". Submitted. 2009.
W.J. Lee, N.J.
Cho, A. Xiong, J.S. Glenn, C.W. Frank. "Poly(lactic-co-glycolic
acid) nanoparticles improve the viability of liver-derived cells encapsulated in
a poly(ethylene glycol) hydrogel". Submitted. 2009. Ph.D. mentoring
project
N.J. Cho, G. Wang, M. Edvardsson, F. Hook, C.W.
Frank. "a-helical peptide-induced vesicle rupture reveals new insight
into the vesicle fusion process as monitored in situ by QCM-D and
reflectometry¡±. May 21; 81(12): 4752-61, 2009. Analytical
Chemistry.
S.M. Yoon, N.J. Cho, K.K. Kanazawa and C.W.
Frank. "Analyzing spur-distorted impedance spectra for the
QCM¡±.
259746; 2009 Apr 10, Journal of Sensors, 2009. Undergraduate mentoring
project
K.K. Kanazawa and N.J. Cho.
"Quartz crystal microbalance as a sensor to characterize
macromolecular assembly dynamic". 824947: Apr 26, Journal of Sensors,
2009. Invited Review Paper
N.J. Cho,
M. Elazar, A. Xiong, W.J. Lee, E. Chiao, E.J. Baker, C.W. Frank,
J.S. Glenn. "Viral infection of human progenitor and liver-derived cells
encapsulated in three-dimensional PEG-based hydrogel". 4(1):11001, Biomedical
Materials, 2009. Cover illustration and Feature
article.
N.J. Cho, K. Kanazawa, J.S. Glenn, C.W.
Frank. "Employing two different quartz crystal microbalance models to
study changes in viscoelastic behavior upon transformation of lipid vesicles to
a bilayer on a gold surface". Analytical Chemistry. 2007 Sep 15;
79(18): 7027-35. Cover illustration.
N.J. Cho, S.J.
Cho, K.H. Cheong, J.S. Glenn, C.W. Frank. "Employing an amphipathic viral peptide to create a lipid bilayer
on Au and TiO2". Journal of the American Chemical Society. 2007 Aug
22; 129(33): 10050-1.
N.J. Cho, K.H. Cheong, C.H.
Lee, C.W. Frank, J.S. Glenn. "Binding dynamics of hepatitis C virus' NS5A amphipathic peptide
to cell and model membranes". Journal of Virology. 2007 Jun;
81(12): 6682-9.
N.J. Cho, S.J. Cho, J.O. Hardesty, J.S.
Glenn, C.W. Frank. "Creation of lipid partitions by deposition of amphipathic viral
peptides". Langmuir. 2007 Oct 9; 23(21): 10855-63.
N.J. Cho, J.N. D'Amour, J. Stalgren, W. Knoll, K.K.
Kanazawa, C.W. Frank. "Quartz resonator signatures under Newtonian liquid loading for
initial instrument check". Journal of Colloid and Interface Science. 2007 Nov
1; 315(1): 248-54.
N.J.Cho, "Viral Peptide Isolated From the Hepatitis C Virus (HCV):
Interactions with Lipid Assemblies and Biotechnological Applications" AIChE, Salt Lake
City, Utah Education, Meet the Faculty Candidate Session, 2010, Poster
N.J. Cho, "Reconstitution of a functionally-active full length Hepatitis C
Virus polymerase on a biomimetic membrane platform", Roche Global Symposium,
Basel, Switzerland, 2010, Invited talk
N.J. Cho,
"Reconstitution of a
functionally-active full length Hepatitis C Virus polymerase on a biomimetic
membrane platform",
17th International Meeting on Hepatitis C Virus and Related Viruses at Yokohama,
Japan, 2010, Invited talk
N.J. Cho, "Viral Peptide Isolated from
the Hepatitis C Virus (HCV): Interactions with Lipid Assemblies and
Biotechnological Applications",
National University of Singapore Department of Chemical and Biomolecular
Engineering, 2010, Invited talk
N.J. Cho, "Viral Peptide Isolated from
the Hepatitis C Virus (HCV): Interactions with Lipid Assemblies and
Biotechnological Applications",
Nanyang Technological University School of Chemical and Biomedical Engineering,
2010, Invited talk
N.J. Cho, "Viral Peptide Isolated from
the Hepatitis C Virus (HCV): Interactions with Lipid Assemblies and
Biotechnological Applications",
Academia Sinica Genomics Research Center, 2010, Invited talk
N.J.
Cho, "Viral
Peptide Isolated from the Hepatitis C Virus (HCV): Interactions with Lipid
Assemblies and Biotechnological Applications", National Taiwan University Department of Chemical Engineering,
2010, Invited talk
N.J. Cho, "Viral Peptide Isolated from
the Hepatitis C Virus (HCV): Interactions with Lipid Assemblies and
Biotechnological Applications",
Hong Kong University of Science and Technology Department of Chemical and
Biomolecular Engineering, 2010, Invited talk
N.J. Cho, G.
Wang, M. Edvardsson, J.S. Glenn, F. Hook, C.W. Frank. "Quartz Crystal
Microbalance-Dissipation and Reflectometry to Monitor in Situ the Structural
Transformation of Lipid Vesicles to a Bilayer on a Gold Surface". Materials
Research Society (MRS), 2009, Talk
W.J. Lee, N.J.
Cho, J.S. Glenn, C.W. Frank ¡°Employing a Matrix Equation to Target Specific Drug Release
Profiles¡±. Materials Research Society (MRS) 2009,
Poster
W.J. Lee, N.J Cho, M. Elazar, J.S. Glenn,
C.W. Frank. ¡°Poly(lactic-co-glycolic acid) Nanoparticles Improve the
Viability of Liver-derived Cells Encapsulated in a Poly(ethylene glycol)
Hydrogel¡±. Materials Research Society (MRS), 2009,
Talk
N.J. Cho. H. Dvory-Sobol C.W. Frank, J.S.
Glenn. "Identification of a novel class of HCV
inhibitors". The Gordon Research Conference on Antimicrobial Peptides,
2009, Poster
N.J. Cho. H. Choongho Lee, Phil Pang,
Kay K. Kanazawa, C.W. Frank, J.S. Glenn. "Phosphatidylinositol 4,5-bisphosphate is a ligand
of HCV". American Society for Cell Biology (ASCB), 2008,
Poster
N.J. Cho., H. Choongho Lee, Phil Pang, Kay K.
Kanazawa, C.W. Frank, J.S. "Phosphatidylinositol 4,5-bisphosphate is a ligand of HCV NS5A
and mediates viral genome replication". Materials Research Society (MRS), 2008,
Talk
N.J. Cho., H. Dvory-Sobol, C.W. Frank,
J.S.Glenn, "Identification of small molecule inhibitors of HCV replication
targeting membrane associated nonstructural proteins using a biomimetic
lipid-based platform". The 15th International Symposium on
Hepatitis C Virus and Related Viruses, 2008,
Talk
P.D. Bryson, N.J. Cho, S. Einav,
C.H. Lee, V. Tai, J. Bechtel, M. Sivaraja, C.Roberts, U. Schmitz,
J.S. Glenn ¡°A small molecule inhibits HCV replication and disrupts NS4B
subcellular localization¡±. The 15th International Symposium on Hepatitis C Virus
and Related Viruses, 2008, Poster
N.J. Cho. K.K. Kanazawa,
C.W. Frank, J.S. Glenn. ¡°Electrochemical-QCM investigation of solid-supported lipid
bilayer formed by AH peptide derived from HCV¡¯s nonstructural
protein¡±. Annual meeting of the Electrochemical Society (ECS), 2008,
Talk
C.H. Lee, N.J. Cho., P.H. Pang, C.W.
Frank, J.S. Glenn. ¡°PIP(4,5)P2 is a ligand of HCV NS5A and mediates HCV
genome replication¡±. Annual meeting of the American Association for the Study of Liver
Diseases (AASLD), 2008, Poster
N.J. Cho, C.W. Frank,
J.S. Glenn ¡°Binding dynamics of Hepatitis C Virus' Nonstructural proteins to
Cell and Model Membranes¡±. Annual meeting of The American Association for the Study of Liver
Diseases (AASLD), 2008, Poster
N.J. Cho, H.
Dvory-Sobol, A. Xiong, C.W. Frank, J.S. Glenn. ¡°The antiviral effects and
lysis potency of the AH peptide in the hepatitis C virus based on the intact
vesicle model system¡±. The American Society of Virology (ASV), 2008,
Talk
N.J. Cho ¡°Membrane on a CHIP analysis by QCM-D: development and
applications¡±. Inviter: Dr. Myoung-Hee Kim, Dean, College of Engineering, Ewha
Womans University, 2007, Invited talk
N.J. Cho, C.W.
Frank, J.S. Glenn ¡°Translating hydrogel technology into novel engineered liver
tissues¡±. Interdisciplinary Translational Research Proposal Award
Presentation (ITRP) Beckman Center, Stanford University, 2007, Invited
talk
N.J. Cho, ¡°Preparation-dependent
vesicle aging effects on vesicle fusion and bilayer formation¡±. Genencor
Corporation, 2005, Invited talk
N.J. Cho,
C.W. Frank, ¡°Lipid Bilayer Membrane on Gold & TiO2 Solid Supports: From
Liposomes to Supported, Planar Bilayers¡±. Materials Research Society, 2005, Poster
R.A. Bauer, N.J. Cho, C.W. Frank,
¡°Influence of Vesicle Size
on the Formation of Supported Lipid Bilayers¡±. CPIMA conference,
2004, Poster
N.J. Cho, C.W. Frank, ¡°Effect of Ca2+
on Vesicle Fusion Measured by Dynamic Light Scattering and Zeta
Potential¡±. AICHE, 2003, Poster
N.J. Cho,
J.R. Stalgren, C.W. Frank, ¡°Calcium Effect of Ion Binding and Membrane Lateral Tension of
Supported Lipid Bilayers Studied by QCM¡±. AICHE, 2003, Poster
N.J. Cho, H. Kim, C.W. Frank, ¡°Viscoelastic Properties of
Ca2+ incorporated in Phospholipid Monolayer of Various Charged
Headgroups¡±.
AICHE, 2003, Poster
N.J. Cho, L.Y. Hwang, C.W.
Frank, ¡°Preparation-Dependence Vesicle Aging Effect on Vesicle Fusion
and Bilayer Formation¡±. CPIMA conference, 2003, Talk
PIP-2
inhibition-based antiviral and anti-hyperlipidemic therapies.
Application No.: PCT/US06/12085 . Licensed to Eiger
BioPharmaceuticals, Inc.
Selected Publications
Presentations and Posters
Patents
Hydrogels with Increased Permeability for Cell Encapsulation
Ref.: 128-S09-010
Screening for Inhibitors of HCV Amphipathic Helix (AH)
Function Ref.: S08-13, STAN-615WO Licensed to Eiger BioPharmaceuticals
Inc.
Direct micro-patterning of lipid bilayers by employing
amphipathic viral peptides to create a biocompatible barrier. S007-200.
Amphipathic peptide compositions as antiviral agents. S07-204;
STAN-562PRV. In Press. Licensed to Eiger BioPharmaceuticals,
Inc.
Method of fabricating lipid bilayer membranes on solid
supports.
Application No.: PCT/US06/12085. Filing Date:
2006/110350
DLS-based screens for inhibitors of HCV amphipathic helix
(AH) function. S007-220. In Press. Licensed to Eiger BioPharmaceuticals,
Inc.
PIP-2 inhibition-based antiviral and
anti-hyperlipidemic therapies.
Application No.: PCT/US06/12085
. Licensed to Eiger BioPharmaceuticals, Inc.
Book Chapter
N.J. Cho, and C. W. Frank, "Biomimetic thin films as a
QCM-D sensor platform to detect macromolecular interactions.¡± Included in Volume III:
Analysis and Applications of Ultrathin Films of book series ¡°Functional Polymer Thin
Films", Under Review by Wiley-VCH,
2010.