Posters supplementary informations
Contents
Thank you for your interest. You will find on this webpage supplementary informations for various posters and presentations
A yeast functional screen predicts new candidate ALS disease genes.
Abstract
ALS is a devastating adult-onset neurodegenerative disease that attacks upper and lower motor neurons. Symptoms of this disease are a progressive and fatal muscle paralysis, causing death within 2 to 5 years of disease onset.
Mutations in several genes have been linked to both sporadic or familial forms of ALS, including SOD1, TARDBP, FUS/TLS and others. Two of these genes, TARDBP (TDP-43) and FUS/TLS (FUS) both encode similar types of RNA-binding proteins and have been identified as components of pathological inclusions in neurons of ALS patients. An emerging concept suggested by the discoveries of FUS and TDP-43 in ALS is that defects in RNA metabolism might contribute to the pathogenesis.
Poster and supplementary informations
A yeast functional screen predicts new ALS disease genes
High-throughput targeted sequencing to assess the role of RNA-binding proteins in ALS.
Abstract
ALS is a devastating adult-onset neurodegenerative disease that attacks upper and lower motor neurons. Symptoms of this disease are a progressive and fatal muscle paralysis, causing death within 2 to 5 years of disease onset.
Mutations in several genes have been linked to both sporadic or familial forms of ALS, including SOD1, TARDBP, FUS/TLS and others. Two of these genes, TARDBP (TDP-43) and FUS/TLS (FUS) both encode similar types of RNA-binding proteins and have been identified as components of pathological inclusions in neurons of ALS patients. An emerging concept suggested by the discoveries of FUS and TDP-43 in ALS is that defects in RNA metabolism might contribute to the pathogenesis.
Poster and supplementary informations
High-throughput targeted sequencing to assess the role of RNA-binding proteins in ALS
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