Table 1 Encoded Proteins and Their Functions
- The genome of Influenza A and B has 8 segments
Influenza A |
Segment |
Length (nucleotides) |
Protein Name |
Protein (Amino acids) |
Function |
1
|
2350 |
PB2 |
759 |
Cap recognition RNA synthesis |
2 |
2350 |
PB1 |
757 |
RNA synthesis |
3 |
2250 |
PA |
716 |
RNA synthesis |
4 |
1780 |
HA |
566 |
Hemaggluttin, fusion, major surface antigen, sialic acid binding |
5 |
1575 |
NP |
498 |
Nuecleocapsid protein |
6 |
1420 |
NA |
454 |
Neurimindase |
7 |
1050 |
M1 |
252 |
Matrix protein |
|
Spliced |
M2 |
97 |
Ion channels |
8 |
900 |
NS1 |
230 |
Nonstructural protein |
|
Spliced |
NS2 |
121 |
Nucleaur export protein |
Source: adapted from Strauss and Struass (2002, table 4.8, p148), ICTVdb
Table 2 Encoded Proteins and Function of Influenza C
- Influenza C has only 7 segments, and has Hemagglutinin-esterase-fusion protein (HEF) instead of hemmagglutin (HA) or Neuriminidase (NA) on their surfaces
Influenza C |
Segment |
Length (nucleotides) |
Protein Name |
Protein (Amino acids) |
Function |
1
|
2365 |
PB2 |
774 |
Cap recognition RNA synthesis |
2 |
2363 |
PB1 |
754 |
RNA synthesis |
3 |
2183 |
PA |
709 |
RNA synthesis |
4 |
2073 |
HEF |
655 |
Fusion, major surface antigen, sialic acid binding |
5 |
1809 |
NP |
565 |
Nuecleocapsid protein |
6 |
1180 |
- |
- |
Matrix protein |
|
Spliced |
M1 |
242 |
Ion channel?? |
|
Internal initiation |
CM2 |
139 |
|
7 |
934 |
N1 |
286 |
Nonstructural protein |
|
Spliced |
N2 |
122 |
Nuclear export protein |
Source: adapted from Strauss and Struass (2002, table 4.8, p148), ICTVdb