1) Diet and metabolism in aging

1. Greer EL, Dowlatshahi D, Banko MR, Hoang K, Blanchard D, and Brunet A (2007) An AMPK-FOXO pathway mediates the extension of lifespan induced by a novel method of dietary restriction in C. elegans. Curr Biol, 17: 1646-1656. Abstract PDF

2. Greer EL and Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell, 8: 113-127. Abstract PDF

3. Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villen J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM and Brunet A (2011) Chemical genetic screen for AMPKa2 substrates uncovers a network of proteins involved in mitosis. Mol Cell, 44:878-892. Abstract PDF

4. Schaffer BE, Hertz NT, Levin RS, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, and Brunet A. (2015) Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction. Cell Metab, 22: 907-922. Abstract PDF

5. Schroeder EA and Brunet A (2015). Lipid profiles and signals for long life. Trends Endocrinol Metab, 26:589-92. Abstract PDF

6. Webb A, Kundaje A, and Brunet A. (2016) Characterization of the direct targets of FOXO transcription factors through evolution. Aging Cell, 15: 673-685. Abstract PDF

7. Han S, Schroeder EA, Silva-Garcia CG, Hebestreit K, Mair WB and Brunet A (2017) Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan. Nature, 544: 185-190. Abstract PDF

8. Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, and Brunet A (2018) Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science, 359: 1277-1283. Abstract PDF

9. Papsdorf K and Brunet A (2018) Linking lipid metabolism to chromatin regulation in aging. Trends Cell Biol, 29: 97-116. Abstract PDF