3) Mechanisms of stem cell aging

1. Renault VM, Rafalski VA, Morgan AA, Salih DAM, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, and Brunet A (2009) FOXO3 regulates neural stem cell homeostasis. Cell Stem Cell, 5: 527-539. Abstract PDF

2. Rafalski VA, Ho PO, Brett JO, Ucar D, Dugas JC, Pollina EA, Chow LML, Ibrahim A, Baker SJ, Barres BA, Steinman L, and Brunet A (2013) Expansion of oligodendrocyte progenitor cells upon SIRT1 inactivation in the adult brain. Nat Cell Biol, 15: 614-624. Abstract PDF

3. Webb AE, Pollina EA, Vierbuchen T, Urban N, Ucar D, Leeman D, Sewak M, Rando TA, Guillemot F, Wernig M, and Brunet A (2013) Genome-wide interaction between the pro-longevity factor FOXO3 and the neuronal determinant ASCL1 in adult neural stem/progenitor cells. Cell Rep, 4: 477-491. Abstract PDF

4. Benayoun BA*, Pollina EA*, Ucar D*, Mahmoudi S, Karra K, Wong E, Devarajan K, Daugherty AC, Kundaje A, Mancini E, Rando TA, Snyder MP, Baker JC, Cherry M and Brunet A (2014) H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell, 158: 673-688. Abstract PDF Database

5. Webb A, Kundaje A, and Brunet A. (2016) Characterization of the direct targets of FOXO transcription factors through evolution. Aging Cell, 15: 673-685. Abstract PDF

6. Brunet A and Rando T (2017) Interaction between epigenetic and metabolism in stem cell aging. Curr Opin in Cell Biol, 24;45:1-7. Abstract PDF

7. Dulken BW, Leeman DS, Boutet SC, Hebestreit K, and Brunet A (2017). Single cell transcriptomic analysis defines heterogeneity and transcriptional dynamics in the adult neural stem cell lineage. Cell Rep, 18: 777-790. Abstract PDF

8. Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, and Brunet A (2018) Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science, 359: 1277-1283. Abstract PDF