Wed 2:30-4:30 PM, Fairchild D-300

Suggested text: Medical Microbiology, Mims CA et al-Mosby, 1993.

Optional, additional text: Bacterial Pathogenesis, Salyers & Whitt-ASM, 1994

Contacts:

David Relman--852-3308 office, VA-Foothill 202, <relman@cmgm>

Stanley Falkow--725-4754 office, Fairchild D-039, <hf.fal@forsythe>

Anthea Lee (TA)--723-2671 lab, Fairchild D-037, <aklee@leland>

April 2-No class

April 9-What is a Pathogen?; Host-Pathogen Relationships. [Stanley Falkow]

Mims 1.1-5; 2.1-10; (3.1-30)

Falkow S. The "zen" of bacterial pathogenicity. In: The Bacteria, Vol. XI. Academic Press, 1990; 3-9.

April 16-Clinical-Pathologic Correlates in Infectious Diseases; Antimicrobial Chemotherapy. [David Relman, Stanley Falkow]

Mims 16.1-14; 35.1-34

April 23-Whooping Cough: Regulation of Virulence, Microbial Adherence.

[David Relman]

Mims 22.1-2; Salyers 63-72

Hultgren SJ, Abraham S, Caparon M, Falk P, St. Geme JW, Normark S. Pilus and nonpilus bacterial adhesins: assembly and function in cell recognition. Cell 1993; 73:887-901.

April 30-Diphtheria, Cholera, and Toxic Shock Syndrome: Extracellular Elements, Toxins, Immune System Subversion. [Stanley Falkow, David Relman]

Mims 10.2-3; 15.1-12; Salyers 113-129

Waldor MK, Mekalanos JJ. Lysogenic conversion by a filamentous phage encoding cholera toxin. Science 1996; 272:1910-1914.

Marrack P, Kappler J. Subversion of the immune system by pathogens. Cell 1994; 76:323-332.

May 7-Mycobacterial and Fungal Diseases: Chronic and Persistent Infections.

[Lalita Ramakrishnan]

Mims 28.9-12

May 14-Rickettsial, Lyme Disease, & other Zoonoses: Vectors and Reservoirs.

[David Relman]

Mims 30.1-16

May 21-Salmonella and Listeria: Entry, Survival and Replication within Host Cells. [Stanley Falkow]

Mims 25.5-6; Salyers 182-189

Garcia-del Portillo F, Finlay BB. The varied lifestyles of intracellular pathogens within eukaryotic vacuolar compartments. Trends Microbiol 1995 3:373-80.

May 28-Diagnosis of Infectious Diseases: Traditional and Molecular; Proof of Disease Causation. [David Fredricks]

Mims 10.6-7; 18.1-15; Salyers 31-32

Fredricks DN, Relman DA. Sequence-based identification of microbial pathogens: A reconsideration of Koch's postulates. Clin Microbiol Rev 1996; 9:18-33.

June 1-5 Dead week

June 6 Hand out final exam (essay)

June 11 Final exam due