CREB signaling Right: Synaptically induced transcription factor activation. The middle (blue) cell was whole-cell patch clamped and filled with a marker while driven to fire action potentials at 5 Hz. The surrounding cells are postsynaptic to the clamped cell and respond by activating CREB in their nuclei by phosphorylating Serine-133 (identified with a phospho-specific antibody; red). Recent overview on the logic of nuclear signaling: Deisseroth K., Mermelstein P.G., Xia H., & Tsien R.W. Current Opinion in Neurobiology, June 2003. Relevant PDFs from our group are available below.

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