Bornaviridae: Borna Disease Virus
Amantadine Sulfate
Drug Profile
This
is your brain on drugs....
A Potential
THerapeutic: AMANDTADINE SULFATE
| The
antiviral drug amantadine sulfate may be a potential treatment for BDV.
It has been demonstrated in vitro to inhibit wild-type BDV replication
and spread of infection. Amantadine has recently been used to
successfully improve clinical symptoms of depression in humans. The
antiviral is commonly used as a therapeutic agent for Parkinson's
Disease. Its antiviral therapeutic actions are most frequently used
against Influenza A. |
| Mechanism
of Action: As an antiviral, amantadine sulfate acts to block the virion from active infection either through preventing penetration or through decapsidation. It is thought to help in treating mood disorders and Parkinson's Disease by actively enhancing dopamine synthesis and release in the brain. |
| Side
Effects: Frequent side effects of amantadine sulfate include nauseau, vomiting, and anorexia. Other side effects, such as mania, may occur infrequently. |
| Mode
of Administration: Oral; The antiviral is reabsorbed by the digestive tract. |
| More
on AMANTADINE SULFATES |