sherlock lab

Wet-lab Funding
  1. MIRA Award: R35 GM131824 - Fitness Effects of Beneficial Mutations

    2. Funding agency : NIH

    Funding period : 5/1/2019 - 4/30/2029

    The major goal of this project is characterize and understand the fitness effects of beneficial mutations that are selected during the evolutionary process, and how those fitness effects changes as a function of the genetic background (epistasis) and growth conditions (environment)

  2. R01 AI136992 - Evolution of Drug Resistance in Candida glabrata

    3. Funding agency : NIH

    Funding period : 12/01/2018 - 11/30/2022

    The goal of this project is to use experimental evolution combined with lineage tracking to isolate and characterize large numbers of drug resistance mutations in the emerging human fungal pathogen Candida glabrata. This project is in collaboration with Sasha Levy and Daniel Fisher at Stanford, and Frank Rosenzweig at Georgia Tech.

  3. R01 HG010378 - Comparative Functional Genomics of Yeast

    4. Funding agency : NIH

    Funding period : 9/1/2019 - 6/31/2023

    The goal of the project is to understand how genetic interaction networks change over evolutionary time. We will be using Tn-Seq (SATAY) and CrisprSeq across 5 related yeast species to determine essential genes, and epistatic interactions. This project is in collaboration with Sasha Levy at Stanford and Maitreya Dunham at the University of Washington.

Database/Informatics Projects Funding
  1. R01 DE015873 - Genomic Database for Candida albicans

    2. Funding agency : NIH

    Funding period : 4/1/2004 - 3/31/2025

    The grant funds the creation and maintenance of a genomic database for Candida albicans, and subsequent curation of C. albicans gene products. This grant supports the Candida Genome Database.