C. elegans Wnt signaling
The following table “ Wnt signaling in different developmental processes in the worm and the players involved” has been assembled by David Eisenmann (Latest update June 2002, send comments/corrections here). Thanks to David for this contribution.
Note that whereas some of these developmental processes, such as P2>EMS signaling are somewhat different from the more familiar Wnt signaling events, other Wnt signaling pathways in C. elegans, such as the postembryonic Q migration are “canonical” in the sense that they use the same components as vertebrate/Drosophila pathways.
Protein/gene |
|
P2-> EMSE fate |
P2->EMSspindle rot. |
VPC fate |
Q progeny migration. |
P12 fate |
T cell polarity |
P7.p polarity |
V cells |
gonad migration |
|
Porcupine |
|
5, 6 |
20 |
3 |
|
|
|
|
|
|
|
Wnt |
|
5, 6 |
|
|
9 |
1 |
24, 25 |
|
23 |
|
|
Frizzled |
|
5, 6 |
20 |
|
MIG-1 9, 27 |
1 |
14, 15 |
14, 15 |
23 |
|
|
Disheveled |
|
|
|
26 |
26 |
26 |
|
|
|
|
|
GSK3 |
|
20 |
20 |
|
|
|
|
|
|
|
|
Axin** |
|
|
|
3 |
PRY-1 8 |
PRY-1 3 |
|
|
PRY-1 8, 23 |
|
|
APC |
|
5 |
|
11 |
|
|
no? 31 |
|
|
|
|
b-catenin |
|
5 |
|
4 |
8 |
2 |
no 28 |
|
23 |
3 |
|
TCF |
|
7 |
|
|
28, 29 |
|
28 |
|
|
3 |
|
target gene |
|
|
|
4 |
10 |
1 |
|
|
23 |
|
|
LIT-1 (NLK) |
|
yes 12, 13, 16 |
|
no 3 |
|
|
yes 13 |
|
|
|
|
MOM-4 (TAK) |
|
yes 6, 16, 17 |
|
|
|
|
no 31 |
|
|
|
|
MIG-14 (?) (pka MOM-3) |
|
yes 6 |
yes 20 |
yes 2 |
yes 9 |
yes 2 |
no 30, 31 |
yes 21 |
|
yes 2, 19 |
|------ embryonic ----------||------------------------ postembryonic ------------------------------------------------------|
** pry-1 encodes an Axin homolog
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2 Eisenmann and Kim 2000. Genetics 156: 1097-1116
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22 H. Korswagen, personal communication
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25 Herman et al. 1995. Cell 83: 101-110
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27 S. Clark, personal communication
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