Small molecules in Wnt signaling

There is significant interest in finding small molecules that can either activate or inhibit Wnt signaling. Blocking Wnt signaling, especially at the level of the nuclear complex between beta-catenin and TCF may be useful to intefere with tumor growth. The following table lists compounds that have been reported to modulate Wnt signaling by targeting various components of the pathway, resulting in either inhibition or activation (sometimes by blocking negative Wnt components). See De Pellegars-Malhortie et al, (2024) , Yang et al, (2022),  Dodge 2010, Chen 2010, Barker 2006, Meijer 2004, Kahn 2014  for reviews. See Kulak et al (2015) for a discussion of side effects of Tankyrase inhibitors