Effects of ectopic expression of Wnt genes

(updated Nov 9, 2000)

phenotype/
effect

tumors

autocrine transformation C57 or RAC

all from Shimizu 1997

paracrine
transformation
all from Shimizu 1997

increase
b-catenin
all from Shimizu 1997

duplication axis in Xenopus

somite myogenesis

kidney epithelial induction

axonal
remodeling

 Neurotrophin-3
expression
all from Patapoutian 1999

 aggregation cardiac myocytes

 Expansion hematopoietic stem cells

 gene


 
       

   

 Wnt-1

 yes
Nusse, 1982
 yes
 yes
 yes
 yes
McMahon,1989
 yes
Munsterberg 1995
Activates Myf5
Tajbakhsh 1998
 yes
Kispert 1998
 no
Lucas 1998
   
 Yes
Austin 1997

 Wnt-2

yes
Roelink 1992
 yes
 yes
 yes
 yes
Landesman 1997
           

 Wnt-3

 yes
Roelink 1990
yes
 yes
 yes
 
yes
Munsterberg 1995
.        

 Wnt3A

.
 yes
yes
 yes
 yes
Wolda 1993
   yes Kispert 1998      Yes Toyofuku 2000  Yes Willert 2003

 Wnt4

unknown, but see Bradbury 1995.
 no
 yes
no in
Shimizu 1997
 no
 no
Ungar 1995
yes
Munsterberg 1995
Activates Myf5 and MyoD
Tajbakhsh 1998
 yes, Herzlinger1994
   yes    

 Wnt-5A

.
 no
 no
no
 no
Torres 1996
but yeswith HFz5 He 1997
Activates Myf5 and MyoD
Tajbakhsh 1998
 no Kispert 1998    no  Yes Toyofuku 2000
 Yes
Austin 1997

 Wnt-5B

.
 yes in
Wong1994
no in
Shimizu 1997
 no
 no
             

 Wnt-6

.
 no in
Wong1994
yes in
Shimizu 1997
 no
 no
 
Activates Myf5 and MyoD.
Tajbakhsh 1998
         

 Wnt-7A

.
 yes
 no
 low
 
 no
Munsterberg 1995
Activates MyoD
Tajbakhsh 1998
 yes Kispert 1998
 yes
Lucas 1998
 yes    

 Wnt-7B

.
 yes in
Wong1994
no in
Shimizu 1997
no
 no
yes (J.Brown, Pers. Comm)
 no
Munsterberg 1995
 yes Kispert 1998
 yes
(Gaston and Salinas, unpublished)
 yes    

 Wnt-8A

.      
 yes
Christian 1993
           

 Wnt-8B

.      
 yes
Cui 1995
           

 Wnt-10B

 yes
Lee 1995
     Yes

Ross, 2000

           
 Yes
Austin 1997

 Wnt-11

 
 yes
Christiansen 1996
   
 yes in Ku 1993
no in Du 1995
  no Kispert 1998