FRP/FrzB genes and interactions with Wnts
(updated July 2024)
Gene linked to Genecards |
Interacts With |
Expression PatternSee Leimeister, 1998 |
Mutant Phenotype |
---|---|---|---|
heart, kidney, lung, brain, aorta, otic vesicle, neural crest | increased trabecular bone
mineral density, volume and mineral apposition rate
growth of retinal ganglion cell axons (Rodriguez, 2005) anteroposterior axis elongation defects (with SFRP2 mutation) Satoh, 2006 |
||
wingless (Rattner, 1997) | gut, eye retina, lung, brain | anteroposterior axis elongation
defects (with SFRP1 mutation) Satoh,
2006
Regulating Nkx2.2 Expression Lei, 2006 |
|
|
cartilage, anterior and posterior mesoderm, limb bud, kidney, testis | ||
ovary, brain, kidney,lung, endometrium | Pyle's disease, bone density. Simsek Kiper 2016 | ||
SFRP5 | pancreas | ||
Sizzled | ventrolateral mesoderm | ogon locus in Zebrafish,
ventralized phenotypes similar to the chordino (dino) mutant Yabe
et al, 2003
Inhibits tolloid proteases Muraoka 2006, Lee, 2006, |
Alignment of Five human or mouse SFRPs
Several other proteins contain a CRD motif similar to the frizzleds (reviewed by Pej and Grishin 2012).
- the alpha 1 chain of mouse type XVIII collagen (Rehn M, 1995 )
- human carboxypeptidase Z (Song L, 1997).
- several receptor tyrosine kinases (Xu and Nusse, 1998, Masiakowski 1998
- Corin, a mosaic transmembrane serine protease (Yan 1999)