Drosophila and C. elegans Frizzleds

Frizzled gene group resource (Flybase)

Gene

(Flybase)

Phenotype

Wnt interaction

Drosophila (complete set)

fz

CG17697
tissue polarity, segment polarity (wg-like) when Dfz2 is also removed

 binds Wg,Dwnt-2, DWnt-4 Wu 2002 Bhanot 1996 Rulifson 2000) signals to Armadillo (Nusse, 1997)

Fz and Dfz2 are redundant as Wg receptors ( Bhat, 1998; Kennerdell, 1998; Muller 1999, Bhanot et al, 1999, Chen 1999)
fz2

CG9739

segment polarity (wg-like) when fz is also removed
Down-regulated by Wg Cadigan 1998
synapse development (Packard, 2002)

 binds Wg DWnt-2, DWnt-4 (Wu 2002 Bhanot 1996, Cadigan 1998, Rulifson 2000), signals to Armadillo (Nusse, 1997)

Fz and Dfz2 are redundant as Wg receptors ( Bhat, 1998; Kennerdell, 1998; Bhanot et al, 1999, Muller 1999; , Chen 1999)
 fz3

CG16785

Attenuates wingless signaling
Upregulated by Wg Sato A, 1999
Sivasankaran 2000
 Binds Wg, DWnt-2 Wu 2002 ,Sato A, 1999
 fz4

CG4626

  unknown DWnt-4, WntD (then called DWnt-8) Wu 2002

smo

CG11561

segment polarity, part of Hedgehog receptor complex
smo does NOT bind wingless
 No known ligand


 

 

C. elegans

interacts with
 lin-17 lin-44
egl-20

cwn-1

  genetic (Sawa H, 1996 )
Harris J, 1996

mechanosensory neuron polarity (Hillard, 2006)

affects migration neurons (Pan, 2006)
 mom-5 mom-2  genetic
 mig-1 egl-20  genetic

Promotes migration neurons (Pan, 2006)