Drosophila and C. elegans Frizzleds



gene Flybase	Phenotype	Wnt interaction
Drosophila (complete set)
fz CG17697	tissue polarity, segment polarity (wg-like) when Dfz2 is also removed	binds Wg,Dwnt-2, DWnt-4 Wu 2002 Bhanot 1996 Rulifson 2000) signals to Armadillo (Nusse, 1997) Fz and Dfz2 are redundant as Wg receptors ( Bhat, 1998; Kennerdell, 1998; Muller 1999, Bhanot et al, 1999, Chen 1999)
fz2 CG9739	segment polarity (wg-like) when fz is also removed Down-regulated by Wg Cadigan 1998 synapse development (Packard, 2002)	binds Wg DWnt-2, DWnt-4 (Wu 2002 Bhanot 1996, Cadigan 1998, Rulifson 2000), signals to Armadillo (Nusse, 1997) Fz and Dfz2 are redundant as Wg receptors ( Bhat, 1998; Kennerdell, 1998; Bhanot et al, 1999, Muller 1999; , Chen 1999 )
fz3 CG16785	Attenuates wingless signaling Upregulated by Wg Sato A, 1999 Sivasankaran 2000	Binds Wg, DWnt-2 Wu 2002 ,Sato A, 1999
fz4 CG4626	unknown	DWnt-4, WntD (then called DWnt-8) Wu 2002
smo CG11561	segment polarity, part of Hedgehog receptor complex smo does NOT bind wingless	No known ligand

C. elegans	interacts with
lin-17	lin-44 egl-20 cwn-1	genetic (Sawa H, 1996 ) Harris J, 1996 mechanosensory neuron polarity (Hillard, 2006) affects migration neurons (Pan, 2006)
mom-5	mom-2	genetic
mig-1	egl-20	genetic Promotes migration neurons (Pan, 2006)

gene