Lymphocyte
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Signaling in normal lymphocyte activation and in hematological malignancies
Disturbances in the signaling cascade arising from the genetic or epigenetic lesions further contribute to development of malignancy. Therefore, intracellular signaling pathways in malignant lymphocytes significantly deviate from normal preset. A methodical evaluation of this deviation can provide significant insight into the physiological function as well as etiology of specific malignant lymphopoiesis. I intend to determine the differences in signaling cascades between different lymphocyte subsets and the alteration of this in different malignant lymphoid cells. In this context i) I will attempt to apply hi-dimensional flow cytometry, combined with phosphoflow, calcium influx assay to establish relationship between cell surface expression and intracellular signaling. ii) In addition, establishment of correlation with several molecules like BCL-2 and Ki67, known be expressed aberrantly in leukemia and lymphoma cells would be beneficial. I anticipate these collaborative studies will significantly strengthen our understanding the etiology of leukemia and lymphoma as well as provide a tool for detection of the early disease.
Calcium signaling in B cells
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