Wnt signaling components as Wnt pathway targets December 2004
Wnt signaling can promote the expression of several Wnt pathway components, indicating that feedback control is a key feature of Wnt signaling regulation.
|
Target Gene |
Effect of Wnt signal on target gene expression |
Effect of changes in target gene expression on Wnt pathway |
Target gene interacts with: |
Reference |
|---|---|---|---|---|
|
Fz |
Down |
Inactivate |
Wnt |
|
|
Dfz2 |
Down |
Inactivate |
Wnt |
|
|
Dfz3 |
Up |
Activate |
Wnt |
|
|
Fz7 |
up |
|
Wnt |
|
|
Arrow/LRP |
Down |
Inactivate |
Wnt |
|
| Dickkopf | Up | Inactivate | LRP | |
|
Dally (HSPG) |
Down |
|
Wnt |
|
|
Wingful/notum |
Up |
Inactivate |
HSPG? |
|
|
naked |
Up |
Inactivate |
Dsh |
|
| nemo | Up | Inactivate | TCF | Zeng , 2004 |
|
Axin2 |
Up |
Inactivate |
b-catenin |
|
|
b-TCRP |
Up |
Inactivate |
b-catenin |
|
|
TCF1 (dn) |
Up |
Inactivate |
TCF |
|
|
LEF1 |
Down |
Activate |
b-catenin |