Drosophila and C. elegans Frizzleds (updated April 2006)

see also:

gene

Flybase

Phenotype

(The Interactive Fly)

 Wnt interaction

Drosophila (complete set)
fz

CG17697
 frizzled
tissue polarity, segment polarity (wg-like) when Dfz2 is also removed

 binds Wg,Dwnt-2, DWnt-4 Wu 2002 Bhanot 1996 Rulifson 2000) signals to Armadillo (Nusse, 1997)

Fz and Dfz2 are redundant as Wg receptors ( Bhat, 1998; Kennerdell, 1998; Muller 1999, Bhanot et al, 1999, Chen 1999)
fz2

CG9739
 Dfrizzled2
segment polarity (wg-like) when fz is also removed
Down-regulated by Wg Cadigan 1998
synapse development (Packard, 2002)

 binds Wg DWnt-2, DWnt-4 (Wu 2002 Bhanot 1996, Cadigan 1998, Rulifson 2000), signals to Armadillo (Nusse, 1997)

Fz and Dfz2 are redundant as Wg receptors ( Bhat, 1998; Kennerdell, 1998; Bhanot et al, 1999, Muller 1999; , Chen 1999)
 fz3

CG16785
DFrizzled3
Attenuates wingless signaling
Upregulated by Wg Sato A, 1999
Sivasankaran 2000
 Binds Wg, DWnt-2 Wu 2002 ,Sato A, 1999

 fz4

CG4626

  unknown DWnt-4, WntD (then called DWnt-8) Wu 2002

 

smo

CG11561
smoothened
segment polarity, part of Hedgehog receptor complex
smo does NOT bind wingless
 No known ligand

This figure shows the binding between Drosophila Frizzleds and Wnts (Wu and Nusse, 2002) (PDF file)
C. elegans interacts with
 lin-17 lin-44
egl-20

cwn-1

  genetic (Sawa H, 1996 )
Harris J, 1996

mechanosensory neuron polarity (Hillard, 2006)

affects migration neurons (Pan, 2006)
 mom-5 mom-2  genetic
 mig-1 egl-20

 genetic

Promotes migration neurons (Pan, 2006)