This alignment includes the two human APCs and two Drosophila
APC genes identified thusfar.
HAPC1 --MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDE
HAPC2 MASSVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQE
DAPC1 ------------------------------------------------------------
DAPC2 ------------------------------------------------------------
HAPC1 A--MASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMG
HAPC2 ARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPTLGPEPAARTP-------EGSPVHGS
DAPC1 M--LEPTLTPDLEEGIAELSLEDVDVDSVPER-KPHFLDYDA--------------VPPP
DAPC2 ------------------------------------------------------------
HAPC1 SFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE
HAPC2 GPSKDSFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVE
DAPC1 DY-EEGFGASSGEQLKMDKKYERDGEVSDYELAASGYTKKEFTQDDNTLHFTQSAVGLGS
DAPC2 ------------------------------------------------------------
HAPC1 N-FSLQTDLTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIAR--IQQIEKDILRIRQ
HAPC2 TQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASR--LEQIDKELLEAQD
DAPC1 G-AVGKKPAAKHFLDENPIPPDYMLAQELREMREHRS-LDRNFERQSAQQQQLDELPPRN
DAPC2 ------------------------------------------------------------
HAPC1 LLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLS
HAPC2 RVQQTEPQALLAVKSVPVD---------E-DPETEVPTHPED---GTPQPGN--------
DAPC1 GGGSPASAG-RPSRSKEPS--YTLSRFLDGDAPAPAPRLPKG-AAWTTSFDERYTSSAVE
DAPC2 ------------------------------------------------------------
HAPC1 SSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCL
HAPC2 ----------------SKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCL
DAPC1 AT------------LGSKVECVYSLLSMLGSNDPLEMAKKFLELSGNAQSCATLRRSGCM
DAPC2 ------------------------MTLNESDATRLELTRNFLELSRNPETCTALRSSDCI
: . : ::.:* :* . ::* ::* *.*:
HAPC1 PLLIQLLHGNDKDS---VLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLL
HAPC2 PLLLQILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVL
DAPC1 PLLVQMMHAPDN-------------DQEVRKCAEQALHNVVHSHPDEKAGRREAKVLRLL
DAPC2 QLLVQILHANDEG------------LSTAKKYASQALHNIVHNNPEEKERQREVKMLRLL
**:*::*. : . .: *. ****::..:*:: ::* ::*::*
HAPC1 EQIRAYCETCWEWQEA--HEP-GMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMN
HAPC2 EQIRAYCETCWDWLQARDGGPEGGGAGSAPIP--IEPQICQATCAVMKLSFDEEYRRAMN
DAPC1 DQIVDYCSFLKTLLQS--GGE-AIADDSD------RHPLA-AISSLMKVSFDEEHRHAMC
DAPC2 DQILDYCNFLHTQLQS--GGE-AIADDED------RHPLA-AMKLLMKASFDEEHRQTMC
:** **. :: . .. . :. * :** *****:*::*
HAPC1 ELGGLQAIAELLQVDCEMYG-LTNDHYSITLRRYAGMALTNLTFGDV--ANKATLCSMKG
HAPC2 ELGGLQAVAELLQVDYEMHK-MTRDPLNLALRRYAGMTLTNLTFGDV--ANKATLCARRG
DAPC1 ELGALHAIPNLVHLDHAVHGPKPEDQCCNSLRRYALMALTNLTFGDE--NNKALLCGQKQ
DAPC2 ELGALKAIPNLVHLDHAVHGPAAGREQCNALRSYGLMALTNLTFGDENVHNKSYLCGQRQ
***.*:*:.:*:::* :: . :** *. *:******** **: **. :
HAPC1 CMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKEST
HAPC2 CMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKEST
DAPC1 FMEALVAQLDSAPDDLLQVTASVLRNLSWRADSNMKAVLNEIGTVTALALAAMRNRSENT
DAPC2 FMEVVIAQLNTAPDELLQVLAGVLRNLSWRADKHMKTIFNELGTVTSLARAAMQNKNENT
*..::*** : .::* ** :.:********* : * :.* *:*.:* ..:. .*.*
HAPC1 LKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSS
HAPC2 LKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSS
DAPC1 LKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSS
DAPC2 LKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSS
**::**********.: *** :* *****.***. *:*. :::* ***..*********
HAPC1 LIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAV
HAPC2 LVATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAV
DAPC1 HIAVCEPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSARSAEDQKFLWDNGAV
DAPC2 HIAVCEPYRQILRRYNCLAILLQQLKSESLTVVSNSCGTLWNLSARCPEDQQYLIDHNAI
:*. * :**:** *** ***:*.*.***:***:********** ..**: * * .*:
HAPC1 SMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSS-----LPSLHVRKQKA
HAPC2 GMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGS----CVPSLYVRKQRA
DAPC1 PMLRSLIHSKHAMISEGSSSALKNLLNFRPAVQNHHQLDPIARSMGLKALPTLEARKAKA
DAPC2 PLLRALISSKNSMIAEGSASALKNLVNFRATQELMPNGD----------GGSLPLDKEAG
:*: *: **: **: **::**:**: *.: :* * .
HAPC1 LEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNM
HAPC2 LEAELDARHLAQALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASD-------SGCF
DAPC1 LQQELGERHTAETCDNLD--------------------------------------TGG-
DAPC2 HGGTLPRRFSSLRLSSNP--------------------------------------TG--
* :. : . :*
HAPC1 T-----VLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNY--HPATENPGT
HAPC2 DDDDAPSSLAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAA
DAPC1 ------------------------------------KLDKER---------------ASS
DAPC2 ------------------------------------SLKKVR---------------PST
* : .:
HAPC1 SSKRG-LQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTH
HAPC2 VAAKAKAKLALAVARIDQLVEDISALHTSSDD----------------------------
DAPC1 SSRRHPAPRLTRSAMLTKS-ESRDSVYSAKSDC---------------------------
DAPC2 VS--------TTGFLNRKC-ESRESIYSGKSD----------------------------
: : *. .::::...*
HAPC1 SNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSNDGYGKRGQMKPSIESYSEDDE
HAPC2 --SFSLSSGD-PG------------QEAPRE-----------GRAQSCSPCRGPEGGRRE
DAPC1 -AYDHLIRSA-----------------SASD------------AHRKVKPKITDFDLEME
DAPC2 -STKYSTKSE-----------------GAKN------------PFEIVTP----------
. .. : .*
HAPC1 SKFCSYGQYPADLAHKIHSANHMDDNDGELDTPINYS----LKYSDEQLNSGRQSPSQNE
HAPC2 --------------------------AGSRAHPLLRLKAAHASLSNDSLNSG--------
DAPC1 Q-----------------------DTEATEEQPIDYS----VKYSENATKT---------
DAPC2 ----------------------------TEEQPIDYS----MKYMEHKPNS---------
*: . :. ::
HAPC1 RWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGA
HAPC2 ----------------------------------------------------SASDGYCP
DAPC1 ----------------------------------------------------STY-----
DAPC2 ----------------------------------------------------SKT-----
*
HAPC1 NGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEEEQHEE--------EERP
HAPC2 -----------------------REHML--PCPLAALASRREDPRCGQ---------PRP
DAPC1 -----------------------QETDL--DQPTDFSLRYAENQIESDLDISGPAGGQKS
DAPC2 -----------------------FEIDL--DQPTDFSARYKE---------------RRS
* * * :.
HAPC1 TNYSIKYN--EEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKSSSGQSSKTEHMSSSSEN
HAPC2 SRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASR--AGAEPLAGPG--
DAPC1 TITPPAET--VPEKSEGQEILLILDDSVKCYQTEDTPYVISNAAS----VTDLRVAAK--
DAPC2 AQTAQPEL--KSETNEIR----------------SKELQLTKSSS----ATELRNSPG--
: : . : :.:* :: ..
HAPC1 TSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTYCVEDTPICFSRCSSL
HAPC2 ---ISPGARKQAWLPADHLS---KVPEKLAAAPLS-VASKALQKLAAQEGPLSLSRCSSL
DAPC1 -ADREAEVKPEVREVTSKEGAPKKLP-KLSQCGSGSYTPEKPINYCEEGTPGYFSRYDSL
DAPC2 -LVAVSAAKQKIATETETE------------------TAERPINYCEEGTPGSFSRFDSL
. .: : .. : . . : * :** .**
HAPC1 SSLSSAEDEIGCNQTTQEADSANTLQIAEIKGKIGTRSAEDPVSEVPSSVHSTLETKSSR
HAPC2 SSLSSAGRP-----GPSEGGDLDDSD----SSLEGLEEAGPSEAELDSTWRAPGATSLPV
DAPC1 SSLD-------------ESGKAN-------QAIVGTDADIKPKLEKQ-------EEQESQ
DAPC2 NSLT-------------EK----------------PEKCMPPKTP----------TKTAV
.** * . . .
HAPC1 LQGSSLSSES-ARHKAVEFPSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDS
HAPC2 AIPAPRRNRGRGLGVEDATPSSSSE--------------NYVQETPLVLSRCSSVSSLGS
DAPC1 P----------AEQVLTKPPTQANS----------------ALETPLMFSRRSSMDSLVH
DAPC2 L----------PVHVDGNTPQNIDS----------------ALETPLMFSRRSSMDSLVG
* .. . ****::** :*:.**
HAPC1 FE-SRSIAS----SVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKR
HAPC2 FE-SPSIAS----SIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAP-----AP
DAPC1 DPDVDVANCDDKSSVVSD-FSRLASGVISPSEIPDSPTQSMPQS----P---------RR
DAPC2 D--DETVACEDNGSVISE-YSRMQSGVISPSELPDSPTQSMPQS----P---------RR
. *: *: * ** ****::**** *:** * *
HAPC1 EVPKNKAPTAEKRESGPKQAA-VNAAVQRVQVLPDA-DTLLHFATESTPDGFSCSSSLSA
HAPC2 QGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSA
DAPC1 NS---VAGSGQNVDS-PP-VV-IPASLQPLRSVFE--DDLSSFNVEHTPAQFSTATSLSN
DAPC2 DR---KVSTQNNLDT-P---------EQKPSTVFE--DKLNRFHVEHTPAAFSCATSLSN
: . : :: : : * .* . ** ::***
HAPC1 LSLDEPFIQKDVELRIMPPVQEND--------NGNE--TESEQPKESNENQE----KEAE
HAPC2 LALHEHYVQQDVELRLLPSACPER---------GGG--AGGAGLHFAGHRRR----EEGP
DAPC1 LSIVD-----DEKAPAVWTEDNEDELLLANCINMGMQRKPTEAVKSTVVNSEVDVAEETI
DAPC2 LSMMD-----DSNANAIRGQRGND-------INGNG---------------------DAP
*:: : * : : : . :
HAPC1 KTIDSEKD--LLDDS-DDDDIEILEECIISAMPTKSSRKGKKPAQTASKLPPPVARK---
HAPC2 APTGSRPR------GAADQELELLRECLGAAVPARLRKVA------SALVPGRRALP---
DAPC1 RSYCTEDTPALLSKVPSNTNLSVISMSSTDPKDATAGQAQMYAHQLSDDVSSNASDCGGA
DAPC2 RSYCTEDTTAVLSKAPSNSDLSILSI----PNDLNANEAQPVPAPRADVTGMDTRMP---
. :. : ::.:: . . :
HAPC1 ---------------P----SQLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPI
HAPC2 ----------------------VPVYMLVP---A--P-----APAQEDDSCTDSAEGTPV
DAPC1 SGHLLQQCIRDGMKKPLGEATSDPIAMLRRGGNEL-P----GYLPSADEMNKFLVEDSPC
DAPC2 --------------------AEDAISKMRCGGNAL-P----SYLPVSDEMSKYYVEDSPC
.: : * . * .*.:*
HAPC1 NFSTATSLSDLTIES----PPNELAAGEGVRGGAQSGEFEKRDTIPTEG-RSTDEAQGGK
HAPC2 NFSSAASLSDETLQG----PPRDQPGGP---AGRQRPT--GRPTSARQA-MGHRHKAGG-
DAPC1 NFSVVSGLSNLTVGSSLVGPAVQLKETE-PSSADQNPE-MKRSLANRSKSRRPPHWQDDS
DAPC2 TFSVISGLSHLTVGSAKAGPVLKLPMRT-AEEAQAPKLPPRRSAVQGDAEPRLPPKKSDS
.** :.**. *: . * . . * . ..
HAPC1 TSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQ
HAPC2 -AGRSAEQSRG---------AGKNRAGLELPLG-----------------RPPSAP--AD
DAPC1 LSSLSIDSEDD-----TNLLSQAIAAGCNRPKSNLGF----SSNGKRSSSLSSSQP--IA
DAPC2 LSSLSMDSDDD-----CNLLSQAIAAGSCRPQP----------SG---ASTSSSLA--NA
:. : . . : :. ..* .
HAPC1 LDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKDFN
HAPC2 KDGSKPG----------------RTRG--DG--ALQSLC---LTTPTEEA----------
DAPC1 INAATSA---------SSLNSAMTVRK-SQQQESYSSV----DSSDSNDN--QSKS-LFE
DAPC2 STSTLCR---------ENGQSKKQVEH-GDK-PNYSSD----DSLDDDDDDARSKS-LFE
. .. : .: . ..
HAPC1 DKLPNNEDRVRGSFAFDSP-HHYTPIEGTPYCFS-RNDSLSSLD-FDDDDVDLSREKAEL
HAPC2 VYC---------FYGNDS-----DE---EPPA---AAPT-PTHRRTSAIPRAFTRERPQG
DAPC1 LCI------LKGMYKTKEPGARAQQMQEQPIVGSSSVQSNPSLKQFDSLPVQLP-SSGQV
DAPC2 QCI------LSGMHKSND----ALESEGEPPG---QRQEISARDRFVSNQVRQI-ESMLA
. .. * .: .
HAPC1 RKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIP
HAPC2 RKEAPAP-------------------SKAAPAAPPPARTQ------------P-------
DAPC1 KRQRHHH--------HHHHHRERERERKDEKLLQECINTG----ISKKINAVP---KNVL
DAPC2 GRQH--------------------------------------------------------
:
HAPC1 DRGAATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSK
HAPC2 --SLIADETPPCYSLSSSASSLS------------------EPEP---SEPPAVHPRGRE
DAPC1 ATSAAALEPCHPMAATTSASALS-----TAAPDVEQKAHATSNPQQQSSTHPSSHILPNP
DAPC2 ------------------------------------------------------------
HAPC1 PQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDS-EDDLLQECISSAMPKK--KKPSRLKG
HAPC2 P-AVTKDPG-------PG-GGRDSS----PSPRAAEELLQRCISSALPRR---RPPVSGL
DAPC1 IDAIATVTDTARSPAAPNQGNGNASQNGLETATGSKDLDSEDRSSDESNQSFIMETMVRL
DAPC2 ------------------------------------------------------------
HAPC1 DNEKHSPRNMGGILG-EDLTLDLKDIQ--RPDSEHGLSPD----SENFDWKAIQEGANSI
HAPC2 R--RRKP------RA---TRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSI
DAPC1 DSALNETCISGASEKHKDPDLMLKSVE--RLTMEFVTSAEQLRSSSHNHSSSNSHKNNSS
DAPC2 ------------------------------------------------------------
HAPC1 VSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFTSNKGPRILKPG
HAPC2 VTWLHQAAAA--T-REASSESDSILSFVSGLSVGSTLQ--P------------PKHRK-G
DAPC1 NNTWNESTCPNDVSFPSVSQTAPVLASLSLDEDATEARSLHELIEITPTNEQQPESLE-G
DAPC2 ------------------------------------------------------------
HAPC1 EKSTLETKKIESESKGIKGGKKVYKSLITGKVRS-NSEISGQMKQPLQANMPSISRGRTM
HAPC2 RQAEGEMGSARRPE---KRG--AASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTV
DAPC1 ETDTLVNGHADSYS-GSSGG---LNFQLGGQVQN-AGVRLEPQRLLFNGTSASIMTNSTM
DAPC2 ------------------------------------------------------------
HAPC1 IHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTS
HAPC2 IYVPSPAPRAQ---PKGTPGPR-ATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKT
DAPC1 IAFEARALAENLLQPAATDDD--TTEMTFSLNSLDLDNIRPPSGMESLNSCYQDHSQPSS
DAPC2 ------------------------------------------------------------
HAPC1 QIGGS-SKAPSRSGSRDSTPS-RPAQQPLSRPIQS-PGRNSISPGRNGISPPNKLSQLPR
HAPC2 SELATLSQPP-----RSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPG
DAPC1 LRQAMPSKSP-R-FARKMFPANLVARRALGHLAGSAESVNSSCNLLDNIKPPSLMDELLD
DAPC2 ------------------------------------------------------------
HAPC1 TSSPSTASTKSSGSGKMSY-TSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNN
HAPC2 ASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARR-GPPPLARAVP--EPGPRGRAGTEA
DAPC1 S-MISVDSIQSEVADGEQD-CSMATTISVSNYETAACDDQTMTVLQSCFDEDEDATMNDY
DAPC2 ------------------------------------------------------------
HAPC1 GNGAN-KKVELSRMSSTKSSGSE-SDRS----ER-PVLVRQSTFIKEAPSP--TLRRKLE
HAPC2 GPGARGGRLGLVRVASALSSGSESSDRS--------GFRRQLTFIKESPGLR---RRRSE
DAPC1 SSAES-TPKHGSTPSPNRRSLTP-KDKRRLTKDRFKTYTIATSCEMEAPEANETLQIEIV
DAPC2 ------------------------------------------------------------
HAPC1 ESAS-FESLSPSS---RPASPTRSQAQTPVLSPSLPDMSLSTHSSVQ-AGGWRKLPPNLS
HAPC2 LSSAESAASAPQG-----ASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAAR
DAPC1 EAAVPVATPSPRANGRRRGSAERYKTQLIECPLALIQPQPDDCPSEQ-LSSIRAMMQQFT
DAPC2 ------------------------------------------------------------
HAPC1 PTIEYNDGR--P-AKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGS
HAPC2 PSPGERPAR-----------RTTSESPSRLP-VRAPAARPETVKRYASLPHISVARRP--
DAPC1 FITDINIGHSQETCESTDHPEDAGESPECDQNSETESCDGQEPDHLPPPPSIVDLRTSVV
DAPC2 ------------------------------------------------------------
HAPC1 SSSILSASSESSEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQT
HAPC2 -DGAVPAAPASADAARRSSDGEPRPLP------R-VAAPGTTWRRIRD-EDVPHILRSTL
DAPC1 KPTTLEPATAVKLVRGRKKPAYVSPYS--MQSQRNSNNAAPSKKKT----LSPTIAKRSL
DAPC2 ------------------------------------------------------------
HAPC1 VSSG-ATNGAESKTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSE
HAPC2 PATALPLRGSTPED--APAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETR--------
DAPC1 VPGGSGVRLPAKKKPTPPPEPAPARLERQGTFVKDEPTNS--NVQVPVVETKPAQTSPTH
DAPC2 ------------------------------------------------------------
HAPC1 KAN--PNIKDSKDNQAKQNVGNGS----VPMRTVGLENRLTSFIQVDAPDQKGTEIKPGQ
HAPC2 -----EPP-GAPAGGQLSLLGSDVD---GPS----------------------------L
DAPC1 RASKLPTKKGTASGGSPSKAGSPKRIPLAPARRMTPQRANTSLRLAAGKSPAASRVVSGR
DAPC2 ------------------------------------------------------------
HAPC1 -NNPVPVSETNESPIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSAR
HAPC2 AKAPISAPFVHEG--LG-VAVGGFPASRHGSPS--RSARVPPFNYVPSPMVVAATTDSAA
DAPC1 VSSTTPPSRSNSN--LNGSSAAAAAAAKINQAQSRIANIWKRVDEAKT-KQSSSNLRTQK
DAPC2 ------------------------------------------------------------
HAPC1 PSQIPTPVNNNTKK---RDSKTDSTESS--GTQSPKRHSGSYLVTSV
HAPC2 EKAPATASATLLE----------------------------------
DAPC1 TKSSNMLNANGTKPTLLRSSTFDNTPSTAGGVKSKLPVVGARK----
DAPC2 -----------------------------------------------