 Introduction Update 2000 Virus Profiles NLV Norwalk SLV Sapporo Pathogen Cards St. Louis Encephalitis HPV2 Had5 Kuru HTLV-1 Guanarito Drug Profile Amantidine AZdU (CS-87) References Web LinksElizabeth Salas & Melissa Valadez Humans and Viruses Human Biology 115A Winter, 2000 Robert Siegel, Instructor Date completed: 3/6/00 |
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 HTLV-1 Description: HTLV-1 is a retorvirus. Virus is enveloped, has incosahedral capsid, and is single stranded RNA. Power: Integrate genome into host DNA using RNA dependent DNA polymerase. Offenses Molecular Attack: Proviral DNA is integrated into lymphoid cells and its presence increases the cytokines produced. Effects of elevated levels of cytokine induce T cells to proliferate continously which leads to mutations in genes controlling growth. Mutations lead to Adult T cell Lymphoma. Clinical Manifestations: T cell lymphoma can become malignat and spread to other lymph nodes. Lymphoma also causes skin legion, bone legions, hypercalcemia, and abnormal liver function. Incubation/Length of Infection: HTLV1 can be a life long infection but not everyone develops symptoms. Defenses Vaccine: None. Treatment: Chemotherapy against cancer. Drugs: Antiretroviral drugs such as AZT. Behavioral: Educate people about transmission which is by sexual contact, shared needles, blood transfusion, and vertical transmission. Game Action: Causes cancer in opponent. HTLV-1 has great oncogenic potential. |
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