The family Bunyaviridae contains five
genera: Bunyavirus, Phlebovirus, Nairovirus, and Hantavirus, and
Tospovirus. One of the largest viral families with over 300 viruses,
the Bunyaviruses have presented a significant challenge to taxonomists.
The viruses have similar morphological features. Ranging g form 80
to 120 nm in size the viral particles are spherical or pleomorphic.
They are enveloped viruses with a single stranded RNA genome of mostly
negative polarity that is divided into three segments. Currently
molecular genomic features and proteins are used to define the Bunyavirus
genera and antigenic data are used to separate the viruses within
each genus.
The Bunyavirus Genus
Named after the Bunyamwera virus ((Bunyamwera, locality
in Uganda), Almost all of the over 150 viruses in this family are transmitted
by mosquitos but have a wide variety of vertebrate hosts. Within
this genus, the California Serogroup Viruses are those that most commonly
affect humans. Causing a febrile type illnesses that
can range from encephalitis to flu-like syndromes, La Crosse virus,
Tahyna virus and snowshoe hare viruses have been most extensively studied.
The Hantavirus Genus
The hantaviruses (named after the Hantaan virus)
are enzootic viruses of wild rodents that cause persistent infections in
their natural hosts. Associated with hemorrhagic fevers and spread
through the inhalation of aerosolized viral particles from fecal material,
the viruses of this group have been increasingly the subject of accelerated
research.. Viruses such as the Hantaan, the Sin Nombre Virus (the
Four Corner's Virus), Prospect Hill, Puumala, and Seoul viruses are
found in this genus.
The Nairovirus Genus
The Nairoviruses are tick borne viruses which are
subdivided into several serogroups. Crimean-Congo hemorrhagic fever
virus is the most medically significant member of this genus and
the best studied representative.
The Phlebovirus Genus
The Phlebovirus genus comprises over 50 viruses
which are transmitted by mosquitoes or phlebotomine flies. Rift Valley
fever virus and sandfly fever virus are the most medically important agents
which have been the greatest focus of study.
The Tospovirus Genus
The tospoviruses are the only members of the family
that infect plants rather than animals. Transmitted by thrips, the
viruses have only recently been recognized as Bunyaviruses.