Smallpox (variola major & minor): The incubation period is 10-14 days, and the onset is acute, with fever, malaise, headache, and backache. A pustular rash develops in which the rash is most profuse on the face, abundant on forearms, but less in lower legs, thighs, and trunk.

Vaccination Complications: Four to five days after vaccination, a papule appears. In most patients, the pustule dries from the center outward, leaving a characteristic scar. However, in some rare cases, immunocompromised individuals or those suffering from eczema may suffer a general vaccinial rash, that can prove even fatal in those whose immune system is severely hampered.

Monkeypox: Symptoms are similar to smallpox, but viral entry in primary infection most likely comes through skin lesions or orally.

Molluscum Contagiosum: The incubation period is 14-50 days. These lesions appear pearly, flesh-colored, raised, and are "umbilicated", and there is often an opening at the top of each nodule where a white core is visible. The lesions are painless, and often heal spontaneously.

Cowpox: These lesions appear as scratches or abrasions, usually on the hands. A vesicle, pustule, then scab forms on skin.

Yabapox: Rarely, large "protuberant" tumors can be seen in humans if there is accidental exposure to the virus.

Tanapox: Nodules develops into papular rash, and lesions ulcerate in the third week. The lesions are usually solitary on arm, face, neck, and trunk.