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VA Palo Alto
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Lab News

07-22-16 Joe receives a K99 award

Joe received an NIH Pathway to Independence Award (K99) from the National Institute on Aging. Congratulations Joe!

04-20-16 Tony talks microglia

Tony is featured in an article in Scientific American. He talks about the impaired function of microglia in aging and Alzheimer's disease and how young blood may help.


04-04-16 Liz to join the faculty at Ohio State

Liz has been granted a position as assistant professor at Ohio State in the Department of Pyschology. Congratulations Liz and go Buckeyes!

03-04-16 Hanadie receives an F32 fellowship

Hanadie received an F32 postdoctoral fellowship for her research on brain endothelial cells. Congratulations Hanadie!

02-18-16 Jian receives his first R01 grant

Jian received an R01 to further his research on mild traumatic brain injury (mTBI). Congratulations Jian!

pubmed: wyss-coray

    Related Articles

    The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging.

    Cold Spring Harb Perspect Med. 2015 Dec;5(12)

    Authors: DeCarolis NA, Kirby ED, Wyss-Coray T, Palmer TD

    Aging is strongly correlated with decreases in neurogenesis, the process by which neural stem and progenitor cells proliferate and differentiate into new neurons. In addition to stem-cell-intrinsic factors that change within the aging stem-cell pool, recent evidence emphasizes new roles for systemic and microenvironmental factors in modulating the neurogenic niche. This article focuses on new insights gained through the use of heterochronic parabiosis models, in which an old mouse and a young circulatory system are joined. By studying the brains of both young and old mice, researchers are beginning to uncover circulating proneurogenic "youthful" factors and "aging" factors that decrease stem-cell activity and neurogenesis. Ultimately, the identification of factors that influence stem-cell aging may lead to strategies that slow or even reverse age-related decreases in neural-stem-cell (NSC) function and neurogenesis.

    PMID: 26627453 [PubMed - indexed for MEDLINE]

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