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VA Palo Alto
The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.

Lab News

07-11-14 Vidhu receives fellowship!
Congratulations to Vidhu for winning a competitive fellowship from the Bluefield Project to Cure FTD to research the effects of GCV on microglia!
06-30-14 Eva and Jinte win awards!
Congratulations to Eva and Jinte for winning this year's Alzheimer's Association for Excellence in Research Award and for Best Poster Prize, respectively!
06-05-14 Our work gets on the cover of Nature Medicine!
NatMed-Cover
Saul Villeda's
 paper gets highlighed on the cover of the June 2014 issue of Nature Medicine.  There is also commentary in the News & Views that can be read here.  

 
05-25-14 Yingbo publishes in Nature Neuroscience!
Congratulations to Yingbo He for publishing about TGF-beta and neurogenesis in Nature Neuroscience.  You can read the paper here

 
05-10-14 Young blood recharges brains of old mice!
Congratulations to Saul Villeda and many members of the TWC lab for publishing in Nature Medicine and receiving a lot of media coverage!  You can read the paper here and read the Stanford coverage story here.  

 
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pubmed: wyss-coray

    Related Articles

    Aging-induced type I interferon response at the choroid plexus negatively affects brain function.

    Science. 2014 Aug 21;

    Authors: Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, Berkutzki T, Barnett-Itzhaki Z, Bezalel D, Wyss-Coray T, Amit I, Schwartz M

    Abstract
    Aging-associated cognitive decline is affected by factors produced inside and outside the brain. Using multi-organ genome-wide analysis of aged mice, we found that the choroid plexus, an interface between the brain and the circulation, shows a type I interferon (IFN-I)-dependent gene expression profile, which was also found in aged human brains. In aged mice, this response was induced by brain-derived signals, present in the cerebrospinal fluid. Blocking IFN-I signaling within the aged brain, partially restored cognitive function and hippocampal neurogenesis, and re-established IFN-II-dependent choroid plexus activity, lost in aging. Our data identify a chronic aging-induced IFN-I signature, often associated with anti-viral response, at the brain's choroid plexus, and demonstrate its negative influence on brain function, thereby suggesting a target for ameliorating cognitive decline in aging.

    PMID: 25147279 [PubMed - as supplied by publisher]

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    ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.

    Nat Neurosci. 2014 Jul;17(7):943-52

    Authors: He Y, Zhang H, Yung A, Villeda SA, Jaeger PA, Olayiwola O, Fainberg N, Wyss-Coray T

    Abstract
    The transforming growth factor-β (TGF-β) signaling pathway serves critical functions in CNS development, but, apart from its proposed neuroprotective actions, its physiological role in the adult brain is unclear. We observed a prominent activation of TGF-β signaling in the adult dentate gyrus and expression of downstream Smad proteins in this neurogenic zone. Consistent with a function of TGF-β signaling in adult neurogenesis, genetic deletion of the TGF-β receptor ALK5 reduced the number, migration and dendritic arborization of newborn neurons. Conversely, constitutive activation of neuronal ALK5 in forebrain caused a marked increase in these aspects of neurogenesis and was associated with higher expression of c-Fos in newborn neurons and with stronger memory function. Our findings describe an unexpected role for ALK5-dependent TGF-β signaling as a regulator of the late stages of adult hippocampal neurogenesis, which may have implications for changes in neurogenesis during aging and disease.

    PMID: 24859199 [PubMed - indexed for MEDLINE]