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VA Palo Alto
The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.

Lab News

07-11-14 Vidhu receives fellowship!
Congratulations to Vidhu for winning a competitive fellowship from the Bluefield Project to Cure FTD to research the effects of GCV on microglia!
06-30-14 Eva and Jinte win awards!
Congratulations to Eva and Jinte for winning this year's Alzheimer's Association for Excellence in Research Award and for Best Poster Prize, respectively!
06-05-14 Our work gets on the cover of Nature Medicine!
NatMed-Cover
Saul Villeda's
 paper gets highlighed on the cover of the June 2014 issue of Nature Medicine.  There is also commentary in the News & Views that can be read here.  

 
05-25-14 Yingbo publishes in Nature Neuroscience!
Congratulations to Yingbo He for publishing about TGF-beta and neurogenesis in Nature Neuroscience.  You can read the paper here

 
05-10-14 Young blood recharges brains of old mice!
Congratulations to Saul Villeda and many members of the TWC lab for publishing in Nature Medicine and receiving a lot of media coverage!  You can read the paper here and read the Stanford coverage story here.  

 
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pubmed: wyss-coray

    Related Articles

    Autoimmunity Contributes to Nociceptive Sensitization in a Mouse Model of Complex Regional Pain Syndrome.

    Pain. 2014 Sep 9;

    Authors: Li WW, Guo TZ, Shi X, Czirr E, Stan T, Sahbaie P, Wyss-Coray T, Kingery WS, David Clark J

    Abstract
    Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose etiology remains poorly understood. The recent suggestion that immunological mechanisms may underlie CRPS provides an entirely novel framework in which to study the condition and consider new approaches to treatment. Using a murine fracture/cast model of CRPS, we studied the effects of B-cell depletion using anti-CD20 antibodies or by performing experiments in genetically B-cell-deficient (μMT) mice. We observed that mice treated with anti-CD20 developed attenuated vascular and nociceptive CRPS-like changes after tibial fracture and 3 weeks of cast immobilization. In mice with established CRPS-like changes, the depletion of CD-20+ cells slowly reversed nociceptive sensitization. Correspondingly, μMT mice, deficient in producing IgM, failed to fully develop CRPS-like changes after fracture and casting. Depletion of CD20+ cells had no detectable effects on nociceptive sensitization in a model of postoperative incisional pain, however. Immunohistochemical experiments showed that CD20+ cells accumulate near the healing fracture but few such cells collect in skin or sciatic nerves. On the other hand IgM-containing immune complexes were deposited in skin and sciatic nerve after fracture in wild-type but not in μMT fracture/cast mice. Additional experiments demonstrated that complement system activation and deposition of membrane attack complexes were partially blocked by anti-CD20+ treatment. Collectively our results suggest that CD20-positive B-cells produce antibodies that ultimately support the CRPS-like changes in the murine fracture/cast model. Therapies directed at reducing B-cell activity may be of use in treating patients with CRPS.

    PMID: 25218828 [PubMed - as supplied by publisher]