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Lab News

03-02-15 Joe wins 2015 New Vision Award
Joe had a very successful conference last week, and was awarded the 2015 New Vision Award at the Charleston Conference on Alzheimer’s disease. This is a highly selective award (with money!) which involves a first round of selections to attend the conference and then a study section-like discussion of the remaining entries at the conference. Joe’s proposal was selected unanimously.
01-27-15 Tony speaks at World Economic Forum
Tony was invited to Davos to discuss how to tackle brain diseases at the World Economic Forum!
12-02-14 Final round for Breakthrough of the Year!
We made the final round for Science's 2014 Breakthrough of the year!  Let everyone know so they can vote!
11-13-14 Vote for the breakthrough of the year!
Help us win Sciene Breakthrough of 2014 by voting for "Young blood fixes old."
09-23-14 Creative Minds: Tony and Tom are in the news!
Congratulations to Tony and Tom for being in the NIH Director's blog.  You can read it here!

pubmed: wyss-coray

    Related Articles

    Go with your gut: microbiota meet microglia.

    Nat Neurosci. 2015 Jun 25;18(7):930-1

    Authors: Mosher KI, Wyss-Coray T

    PMID: 26108718 [PubMed - in process]

    Related Articles

    Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF.

    Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4128-33

    Authors: Kirby ED, Kuwahara AA, Messer RL, Wyss-Coray T

    Abstract
    The adult hippocampus hosts a population of neural stem and progenitor cells (NSPCs) that proliferates throughout the mammalian life span. To date, the new neurons derived from NSPCs have been the primary measure of their functional relevance. However, recent studies show that undifferentiated cells may shape their environment through secreted growth factors. Whether endogenous adult NSPCs secrete functionally relevant growth factors remains unclear. We show that adult hippocampal NSPCs secrete surprisingly large quantities of the essential growth factor VEGF in vitro and in vivo. This self-derived VEGF is functionally relevant for maintaining the neurogenic niche as inducible, NSPC-specific loss of VEGF results in impaired stem cell maintenance despite the presence of VEGF produced from other niche cell types. These findings reveal adult hippocampal NSPCs as an unanticipated source of an essential growth factor and imply an exciting functional role for adult brain NSPCs as secretory cells.

    PMID: 25775598 [PubMed - indexed for MEDLINE]

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