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Lab News

10-06-15 Tony receives a NIH Director's Pioneer Award

Tony received a NIH Director’s Pioneer Award to study mammalian rejuvenation and aging using bioorthogonal chemistry. The press release and project description can be found on the program website.

09-10-15 Liz receives a K99 award

Liz received an NIH Pathway to Independence Award (K99) from the NINDS. Congratulations Liz!

08-04-15 Tony and Saul are featured in The Guardian

Tony and Saul talk in depth about the past and future of rejuvenation in a recent article in The Guardian. The article can be read here.

06-16-15 Tony speaks at TEDGlobalLondon
Tony talks at TEDGlobalLondon. View the presentation here.
03-02-15 Joe wins 2015 New Vision Award
Joe had a very successful conference last week, and was awarded the 2015 New Vision Award at the Charleston Conference on Alzheimer’s disease. This is a highly selective award (with money!) which involves a first round of selections to attend the conference and then a study section-like discussion of the remaining entries at the conference. Joe’s proposal was selected unanimously.

pubmed: wyss-coray

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    Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome.

    Pain. 2014 Nov;155(11):2377-89

    Authors: Li WW, Guo TZ, Shi X, Czirr E, Stan T, Sahbaie P, Wyss-Coray T, Kingery WS, Clark JD

    Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose etiology remains poorly understood. The recent suggestion that immunological mechanisms may underlie CRPS provides an entirely novel framework in which to study the condition and consider new approaches to treatment. Using a murine fracture/cast model of CRPS, we studied the effects of B-cell depletion using anti-CD20 antibodies or by performing experiments in genetically B-cell-deficient (μMT) mice. We observed that mice treated with anti-CD20 developed attenuated vascular and nociceptive CRPS-like changes after tibial fracture and 3 weeks of cast immobilization. In mice with established CRPS-like changes, the depletion of CD-20+ cells slowly reversed nociceptive sensitization. Correspondingly, μMT mice, deficient in producing immunoglobulin M (IgM), failed to fully develop CRPS-like changes after fracture and casting. Depletion of CD20+ cells had no detectable effects on nociceptive sensitization in a model of postoperative incisional pain, however. Immunohistochemical experiments showed that CD20+ cells accumulate near the healing fracture but few such cells collect in skin or sciatic nerves. On the other hand, IgM-containing immune complexes were deposited in skin and sciatic nerve after fracture in wild-type, but not in μMT fracture/cast, mice. Additional experiments demonstrated that complement system activation and deposition of membrane attack complexes were partially blocked by anti-CD20+ treatment. Collectively, our results suggest that CD20-positive B cells produce antibodies that ultimately support the CRPS-like changes in the murine fracture/cast model. Therapies directed at reducing B-cell activity may be of use in treating patients with CRPS.

    PMID: 25218828 [PubMed - indexed for MEDLINE]