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Lab News

09-23-14 Creative Minds: Tony and Tom are in the news!
Congratulations to Tony and Tom for being in the NIH Director's blog.  You can read it here!
07-11-14 Vidhu receives fellowship!
Congratulations to Vidhu for winning a competitive fellowship from the Bluefield Project to Cure FTD to research the effects of GCV on microglia!
06-30-14 Eva and Jinte win awards!
Congratulations to Eva and Jinte for winning this year's Alzheimer's Association for Excellence in Research Award and for Best Poster Prize, respectively!
06-05-14 Our work gets on the cover of Nature Medicine!
NatMed-Cover
Saul Villeda's
 paper gets highlighed on the cover of the June 2014 issue of Nature Medicine.  There is also commentary in the News & Views that can be read here.  

 
05-25-14 Yingbo publishes in Nature Neuroscience!
Congratulations to Yingbo He for publishing about TGF-beta and neurogenesis in Nature Neuroscience.  You can read the paper here

 
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pubmed: wyss-coray

    Related Articles

    Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

    Nat Med. 2014 Jun;20(6):659-63

    Authors: Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T

    Abstract
    As human lifespan increases, a greater fraction of the population is suffering from age-related cognitive impairments, making it important to elucidate a means to combat the effects of aging. Here we report that exposure of an aged animal to young blood can counteract and reverse pre-existing effects of brain aging at the molecular, structural, functional and cognitive level. Genome-wide microarray analysis of heterochronic parabionts--in which circulatory systems of young and aged animals are connected--identified synaptic plasticity-related transcriptional changes in the hippocampus of aged mice. Dendritic spine density of mature neurons increased and synaptic plasticity improved in the hippocampus of aged heterochronic parabionts. At the cognitive level, systemic administration of young blood plasma into aged mice improved age-related cognitive impairments in both contextual fear conditioning and spatial learning and memory. Structural and cognitive enhancements elicited by exposure to young blood are mediated, in part, by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus. Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function.

    PMID: 24793238 [PubMed - indexed for MEDLINE]

    Related Articles

    A revival of parabiosis in biomedical research.

    Swiss Med Wkly. 2014;144:w13914

    Authors: Eggel A, Wyss-Coray T

    Abstract
    Modern medicine wields the power to treat large numbers of diseases and injuries most of us would have died from just a hundred years ago, yet many of the most devastating diseases of our time are still untreatable. Chronic conditions of age such as cardiovascular disease, diabetes, osteoarthritis or Alzheimer's disease turn out to be of a complexity that may require transformative ideas and paradigms to understand and treat them. Parabiosis, which is characterised by a shared blood supply between two surgically connected animals, may just provide such a transformative experimental paradigm. Although forgotten and shunned now in many countries, it has contributed to major breakthroughs in tumour biology, endocrinology and transplantation research in the past century. Interestingly, recent studies from the United States and Britain are reporting stunning advances in stem cell biology and tissue regeneration using parabiosis between young and old mice, indicating a possible revival of this paradigm. We review here briefly the history of parabiosis and discuss its utility to study physiological and pathophysiological processes. We argue that parabiosis is a technique that should enjoy wider acceptance and application, and that policies should be revisited to allow its use in biomedical research.

    PMID: 24496774 [PubMed - indexed for MEDLINE]