The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto.
to get directions.
Tony is featured in an article in Scientific American. He talks about the impaired function of microglia in aging and Alzheimer's disease and how young blood may help.
Liz has been granted a position as assistant professor at Ohio State in the Department of Pyschology. Congratulations Liz and go Buckeyes!
Hanadie received an F32 postdoctoral fellowship for her research on brain endothelial cells. Congratulations Hanadie!
Jian received an R01 to further his research on mild traumatic brain injury (mTBI). Congratulations Jian!
Tony's TED talk has reached 1,000,000 views and is featured in TED's Year in Ideas (starting at 1:07), highlighting the lab's work in one of the biggest scientific steps of 2015.
In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model.
Sci Rep. 2016;6:29015
Authors: Castellano JM, Palner M, Li SB, Freeman GM, Nguyen A, Shen B, Stan T, Mosher KI, Chin FT, de Lecea L, Luo J, Wyss-Coray T
The sharing of circulation between two animals using a surgical procedure known as parabiosis has created a wealth of information towards our understanding of physiology, most recently in the neuroscience arena. The systemic milieu is a complex reservoir of tissues, immune cells, and circulating molecules that is surprisingly not well understood in terms of its communication across organ systems. While the model has been used to probe complex physiological questions for many years, critical parameters of recovery and exchange kinetics remain incompletely characterized, limiting the ability to design experiments and interpret results for complex questions. Here we provide evidence that mice joined by parabiosis gradually recover much physiology relevant to the study of brain function. Specifically, we describe the timecourse for a variety of recovery parameters, including those for general health and metabolism, motor coordination, activity, and sleep behavior. Finally, we describe the kinetics of chimerism for several lymphocyte populations as well as the uptake of small molecules into the brains of mice following parabiosis. Our characterization provides an important resource to those attempting to understand the complex interplay between the immune system and the brain as well as other organ systems.
PMID: 27364522 [PubMed - in process]