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VA Palo Alto
The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.

Lab News

07-11-14 Vidhu receives fellowship!
Congratulations to Vidhu for winning a competitive fellowship from the Bluefield Project to Cure FTD to research the effects of GCV on microglia!
06-30-14 Eva and Jinte win awards!
Congratulations to Eva and Jinte for winning this year's Alzheimer's Association for Excellence in Research Award and for Best Poster Prize, respectively!
06-05-14 Our work gets on the cover of Nature Medicine!
NatMed-Cover
Saul Villeda's
 paper gets highlighed on the cover of the June 2014 issue of Nature Medicine.  There is also commentary in the News & Views that can be read here.  

 
05-25-14 Yingbo publishes in Nature Neuroscience!
Congratulations to Yingbo He for publishing about TGF-beta and neurogenesis in Nature Neuroscience.  You can read the paper here

 
05-10-14 Young blood recharges brains of old mice!
Congratulations to Saul Villeda and many members of the TWC lab for publishing in Nature Medicine and receiving a lot of media coverage!  You can read the paper here and read the Stanford coverage story here.  

 
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pubmed: wyss-coray

    Related Articles

    Noninvasive in vivo monitoring of tissue-specific global gene expression in humans.

    Proc Natl Acad Sci U S A. 2014 May 20;111(20):7361-6

    Authors: Koh W, Pan W, Gawad C, Fan HC, Kerchner GA, Wyss-Coray T, Blumenfeld YJ, El-Sayed YY, Quake SR

    Abstract
    Circulating cell-free RNA in the blood provides a potential window into the health, phenotype, and developmental programs of a variety of human organs. We used high-throughput methods of RNA analysis such as microarrays and next-generation sequencing to characterize the global landscape circulating RNA in a cohort of human subjects. By focusing on genes whose expression is highly specific to certain tissues, we were able to identify the relative contributions of these tissues to circulating RNA and to monitor changes in tissue development and health. As one application of this approach, we performed a longitudinal study on pregnant women and analyzed their combined cell-free RNA transcriptomes across all three trimesters of pregnancy and after delivery. In addition to the analysis of mRNA, we observed and characterized noncoding species such as long noncoding RNA and circular RNA transcripts whose presence had not been previously observed in human plasma. We demonstrate that it is possible to track specific longitudinal phenotypic changes in both the mother and the fetus and that it is possible to directly measure transcripts from a variety of fetal tissues in the maternal blood sample. We also studied the role of neuron-specific transcripts in the blood of healthy adults and those suffering from the neurodegenerative disorder Alzheimer's disease and showed that disease specific neural transcripts are present at increased levels in the blood of affected individuals. Characterization of the cell-free transcriptome in its entirety may thus provide broad insights into human health and development without the need for invasive tissue sampling.

    PMID: 24799715 [PubMed - indexed for MEDLINE]