The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.
10-06-15 Tony receives a NIH Director's Pioneer Award
09-10-15 Liz receives a K99 award
Liz received an NIH Pathway to Independence Award (K99) from the NINDS. Congratulations Liz!
08-04-15 Tony and Saul are featured in The Guardian
Tony and Saul talk in depth about the past and future of rejuvenation in a recent article in The Guardian. The article can be read here.
06-16-15 Tony speaks at TEDGlobalLondon
Tony talks at TEDGlobalLondon. View the presentation here.
03-02-15 Joe wins 2015 New Vision Award
Joe had a very successful conference last week, and was awarded the 2015 New Vision Award at the Charleston Conference on Alzheimer’s disease. This is a highly selective award (with money!) which involves a first round of selections to attend the conference and then a study section-like discussion of the remaining entries at the conference. Joe’s proposal was selected unanimously.
TGF-β signaling in the CNS and role in CNS disease - We discovered that abnormal TGF-β signaling may contribute to Alzheimer’s disease using a number of engineered mouse models that allow us to regulate TGF-β signaling in different cell types. Other studies showed that TGF-β1 can promote accumulation of immune cells in models of autoimmune disease but it can also support the late stages of adult neurogenesis and increase survival of neurons. Engineered mouse models which lack TGF-β receptors in neurons or report activation of signaling by producing indicator proteins are currently being used to study the role of TGF-β signaling in normal CNS function and disease. To try to exploit the beneficial effects of TGF-β signaling in neurons we are developing small molecule activators of this pathway.