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Research Interests
VA Palo Alto
The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.

Lab News

04-20-16 Tony talks microglia

Tony is featured in an article in Scientific American. He talks about the impaired function of microglia in aging and Alzheimer's disease and how young blood may help.

 

04-04-16 Liz to join the faculty at Ohio State

Liz has been granted a position as assistant professor at Ohio State in the Department of Pyschology. Congratulations Liz and go Buckeyes!

03-04-16 Hanadie receives an F32 fellowship

Hanadie received an F32 postdoctoral fellowship for her research on brain endothelial cells. Congratulations Hanadie!

02-18-16 Jian receives his first R01 grant

Jian received an R01 to further his research on mild traumatic brain injury (mTBI). Congratulations Jian!

12-10-15 Tony featured on TED's Year in Ideas

Tony's TED talk has reached 1,000,000 views and is featured in TED's Year in Ideas (starting at 1:07), highlighting the lab's work in one of the biggest scientific steps of 2015.

Research Interests

TGF-β signaling in the CNS and role in CNS disease - We discovered that abnormal TGF-β signaling may contribute to Alzheimer’s disease using a number of engineered mouse models that allow us to regulate TGF-β signaling in different cell types. Other studies showed that TGF-β1 can promote accumulation of immune cells in models of autoimmune disease but it can also support the late stages of adult neurogenesis and increase survival of neurons. Engineered mouse models which lack TGF-β receptors in neurons or report activation of signaling by producing indicator proteins are currently being used to study the role of TGF-β signaling in normal CNS function and disease. To try to exploit the beneficial effects of TGF-β signaling in neurons we are developing small molecule activators of this pathway.

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