The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.
11-13-14 Vote for the breakthrough of the year!
Help us win Sciene Breakthrough of 2014 by voting for "Young blood fixes old."
09-23-14 Creative Minds: Tony and Tom are in the news!
Congratulations to Tony and Tom for being in the NIH Director's blog. You can read it here!
07-11-14 Vidhu receives fellowship!
Congratulations to Vidhu for winning a competitive fellowship from the Bluefield Project to Cure FTD to research the effects of GCV on microglia!
06-30-14 Eva and Jinte win awards!
Congratulations to Eva and Jinte for winning this year's Alzheimer's Association for Excellence in Research Award and for Best Poster Prize, respectively!
06-05-14 Our work gets on the cover of Nature Medicine!
TGF-β signaling in the CNS and role in CNS disease - We discovered that abnormal TGF-β signaling may contribute to Alzheimer’s disease using a number of engineered mouse models that allow us to regulate TGF-β signaling in different cell types. Other studies showed that TGF-β1 can promote accumulation of immune cells in models of autoimmune disease but it can also support the late stages of adult neurogenesis and increase survival of neurons. Engineered mouse models which lack TGF-β receptors in neurons or report activation of signaling by producing indicator proteins are currently being used to study the role of TGF-β signaling in normal CNS function and disease. To try to exploit the beneficial effects of TGF-β signaling in neurons we are developing small molecule activators of this pathway.