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VA Palo Alto
The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.

Lab News

02-04-14 Jian and Ching each publish!
Congratulations to Jian for publishing in Frontiers in Neurology and Ching (Zhaoqing) on publishing in JEM!  You can read Jian's paper here and Ching's paper here!
10-10-13 Tony receives a Transformative R01!
Congratulations to Tony for being a 2013 Transformative R01 Award Recipient!  You can read more about it here
09-04-13 Kurt publishes in Neuron!
Congratulations to Kurt for his beautiful paper in Neuron.  It was also featured on Alzforum!
06-10-13 Jinte wins award!
Congratulations to Jinte for winning a (well-paid) Alzheimer's Association Award for Young Scientists. There was a strong competition this year so this is really awesome.
06-05-13 Kira's thesis defense!
Congratulations to Dr. Kira Mosher for reaching this milestone in her bright career!

Research Interests

TGF-β signaling in the CNS and role in CNS disease - We discovered that abnormal TGF-β signaling may contribute to Alzheimer’s disease using a number of engineered mouse models that allow us to regulate TGF-β signaling in different cell types. Other studies showed that TGF-β1 can promote accumulation of immune cells in models of autoimmune disease but it can also support the late stages of adult neurogenesis and increase survival of neurons. Engineered mouse models which lack TGF-β receptors in neurons or report activation of signaling by producing indicator proteins are currently being used to study the role of TGF-β signaling in normal CNS function and disease. To try to exploit the beneficial effects of TGF-β signaling in neurons we are developing small molecule activators of this pathway.