The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.
07-11-14 Vidhu receives fellowship!
Congratulations to Vidhu for winning a competitive fellowship from the Bluefield Project to Cure FTD to research the effects of GCV on microglia!
06-30-14 Eva and Jinte win awards!
Congratulations to Eva and Jinte for winning this year's Alzheimer's Association for Excellence in Research Award and for Best Poster Prize, respectively!
06-05-14 Our work gets on the cover of Nature Medicine!
Saul Villeda's paper gets highlighed on the cover of the June 2014 issue of Nature Medicine. There is also commentary in the News & Views that can be read here.
05-25-14 Yingbo publishes in Nature Neuroscience!
Congratulations to Yingbo He for publishing about TGF-beta and neurogenesis in Nature Neuroscience. You can read the paper here.
05-10-14 Young blood recharges brains of old mice!
Welcome to the Wyss-Coray Laboratory! Our laboratory studies immune and injury responses in aging and neurodegeneration. A growing body of information in recent years has documented the interchangeability of key proteins between the immune and central nervous systems (CNS). One prominent example, and a focus of our lab, is TGF-β1 which is a key regulator of immune functions but is also necessary for neuronal protection and survival and may have a role in Alzheimer’s disease. Another group of proteins we are interested in constitutes the complement system, which is critical in the removal of pathogens and dying cells not only in the periphery, but likely in the CNS as well. In a less biased approach, we use proteomics to study cellular communication on a larger scale in plasma and relate it to aging and degenerative changes in the CNS.In much of our studies we seek to understand neurodegeneration and neurological disease in the context of immune responses. One exciting hypothesis is that altered or failing immune responses might underlie or at least contribute to age-related degenerative diseases of the nervous system. We use mouse genetics, behavior, cell culture, and proteomic approaches to try to test this hypothesis.
TWC-Lab May 2014