The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.
07-22-16 Joe receives a K99 award
Joe received an NIH Pathway to Independence Award (K99) from the National Institute on Aging. Congratulations Joe!
04-20-16 Tony talks microglia
Tony is featured in an article in Scientific American. He talks about the impaired function of microglia in aging and Alzheimer's disease and how young blood may help.
04-04-16 Liz to join the faculty at Ohio State
Liz has been granted a position as assistant professor at Ohio State in the Department of Pyschology. Congratulations Liz and go Buckeyes!
03-04-16 Hanadie receives an F32 fellowship
Hanadie received an F32 postdoctoral fellowship for her research on brain endothelial cells. Congratulations Hanadie!
02-18-16 Jian receives his first R01 grant
Jian received an R01 to further his research on mild traumatic brain injury (mTBI). Congratulations Jian!
Welcome to the Wyss-Coray Laboratory! Our laboratory studies immune and injury responses in aging and neurodegeneration. A growing body of information in recent years has documented the interchangeability of key proteins between the immune and central nervous systems (CNS). One prominent example, and a focus of our lab, is TGF-β1 which is a key regulator of immune functions but is also necessary for neuronal protection and survival and may have a role in Alzheimer’s disease. Another group of proteins we are interested in constitutes the complement system, which is critical in the removal of pathogens and dying cells not only in the periphery, but likely in the CNS as well. In a less biased approach, we use proteomics to study cellular communication on a larger scale in plasma and relate it to aging and degenerative changes in the CNS.In much of our studies we seek to understand neurodegeneration and neurological disease in the context of immune responses. One exciting hypothesis is that altered or failing immune responses might underlie or at least contribute to age-related degenerative diseases of the nervous system. We use mouse genetics, behavior, cell culture, and proteomic approaches to try to test this hypothesis.
TWC Lab March 2016