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VA Palo Alto
The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.

Lab News

02-04-14 Jian and Ching each publish!
Congratulations to Jian for publishing in Frontiers in Neurology and Ching (Zhaoqing) on publishing in JEM!  You can read Jian's paper here and Ching's paper here!
10-10-13 Tony receives a Transformative R01!
Congratulations to Tony for being a 2013 Transformative R01 Award Recipient!  You can read more about it here
09-04-13 Kurt publishes in Neuron!
Congratulations to Kurt for his beautiful paper in Neuron.  It was also featured on Alzforum!
06-10-13 Jinte wins award!
Congratulations to Jinte for winning a (well-paid) Alzheimer's Association Award for Young Scientists. There was a strong competition this year so this is really awesome.
06-05-13 Kira's thesis defense!
Congratulations to Dr. Kira Mosher for reaching this milestone in her bright career!
Welcome to the Wyss-Coray Laboratory! Our laboratory studies immune and injury responses in aging and neurodegeneration. A growing body of information in recent years has documented the interchangeability of key proteins between the immune and central nervous systems (CNS). One prominent example, and a focus of our lab, is TGF-β1 which is a key regulator of immune functions but is also necessary for neuronal protection and survival and may have a role in Alzheimer’s disease. Another group of proteins we are interested in constitutes the complement system, which is critical in the removal of pathogens and dying cells not only in the periphery, but likely in the CNS as well. In a less biased approach, we use proteomics to study cellular communication on a larger scale in plasma and relate it to aging and degenerative changes in the CNS.In much of our studies we seek to understand neurodegeneration and neurological disease in the context of immune responses. One exciting hypothesis is that altered or failing immune responses might underlie or at least contribute to age-related degenerative diseases of the nervous system. We use mouse genetics, behavior, cell culture, and proteomic approaches to try to test this hypothesis.


TWC-Lab September 2013