Investigator: R. Lane Smith, PhD

Project Staff: Dennis R. Carter, PhD and Scott A. Yerby, PhD

Summary: Cartilage repair and regeneration is critical to the restoration of function of osteoarthritic joints. The objective of this project is to find the mechanical loading conditions that trigger key biological events (e.g., gene expression) within the chondrocyte (cartilage) cell. This information is necessary to understand the role of mechanical loading in cartilage repair and is a prerequisite for the development of a functional cartilage-like substitute for arthritic joints.

Recent Publications:

Lee M, Trindade MCD, T Ikenoue T, EY Lin EY, Schurman DJ, Goodman SB, RL Smith RL: Differential expression of nitric oxide in human chondrocytes during intermittent hydrostatic pressure or shear stress. Transactions of the 19th Annual Meeting of the Society for Physical Regulation in Biology and Medicine, January, 2000.

Lin EY, Trindade MCD, Ikenoue T, Lee M, Goodman SB, Schurman DJ, Smith RL: Intermittent hydrostatic pressure stimulates expression of aggrecan and type II collagen mRNA in human osteoarthritic chondrocytes in vitro. Transactions of the 19th Annual Meeting of the Society for Physical Regulation in Biology and Medicine, January, 2000.

Trindade MCD, Shida J, Ikenoue T, Lee MS, Lin EY, Shah SN, Yerby SA, Goodman SB, Schurman DJ, Smith RL: Effect of intermittent hydrostatic pressure on osteoarthritic chondrocyte pro-inflammatory mediator and matrix metalloproteinase release in vitro. Transactions of the 19th Annual Meeting of the Society for Physical Regulation in Biology and Medicine, January, 2000.

Ikenoue T, Lee M, Lin EY, Trindade MCD, Schurman DJ, Goodman SB, RL Smith RL: Modulation of aggrecan expression in normal human articular chondrocytes by intermittent hydrostatic pressure. Transactions of the 19th Annual Meeting of the Society for Physical Regulation in Biology and Medicine, January, 2000.

Trindade MCD, Shida J, Yerby S, Yaszay B, Goodman SB, Schurman DJ, Smith RL: Intermittent hydrostatic pressure inhibits interleukin-6 and monocyte chemoattractant protein-1 expression by human osteoarthritic chondrocytes in vitro. Submitted to the Journal of Orthopaedic Research.

Funding Source: VA RR&D Merit Review

Years: 1998-2001