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Publications

Peer Reviewed Articles

Kim, C., You, L., Yellowley, C.E., Jacobs, C.R., Oscillatory Fluid Flow Induced Shear Stress Decreases Osteoclastogenesis Through Regulation of RANKL and OPG. Bone, 39:1043-1047, 2006.

Malone, A.M., Batra, N.N., Shivaram, G, Kwon, R, You, L., Kim, C., Rodriguez, J, Jair, K. Jacobs, C.R., The Role of the Actin Cytoskeleton in Oscillatory Fluid Flow Induced Signaling in MC3T3-E1 Osteoblasts. American Journal of Physiology-Cell, Jan 24, Epub, 2007.

Batra NN, Li YJ, Yellowley CE, You L, Malone A, Kim C, and Jacobs CR: Effects of Short-term Recovery Periods on Fluid Induced Signaling in Osetoblastic Cells. Journal of Orthopaedic Research, 38:1909-1917, 2005.

Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, Jacobs CR. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res, 22: 1283-1289, 2004.

Lidan You, Stephen C. Cowin, Michel B. Schaffler, and Sheldon, Weinbaum, A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix, Journal of Biomechanics 2001. 34(11): 1375-1386.

Sheldon Weinbaum, Peng Guo and Lidan You, A new view of mechanotransduction and strain amplification in cells with microvilli and cell processes, Biorheology 38 (2001) 119-142.

Data Ready for Publication

Batra NN, Shivaram G, Kwon R, You L, Chi-Hyun RJ, Malone A, Jair K, and Jacobs CR: The Role of the Actin Cytoskeleton in Oscillatory Fluid Flow Induced Signaling in MC3T3-E1 Osteoblasts. American Journal of Physiology-Cell, Submitted.

You L, Temiyasathi S, Lee P, Kim C, Tummala P, Yao W, Kingery WS, and Jacobs CR: Osteocytes as Mechanosensors in the Inhibition of Bone Resorption Due to Mechanical Loading. Proceedings of the National Academy of Science. Submitted.

In Review - 2006

You, L., Temiyasathi, S., Lee, P., Kim, C., Tummala, P., Yao, W., Kingery, W.S., Jacobs, C.R., Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone, Submitted.

Abstracts - 2006

You, L., Temiyasathit, C., Jacobs. C., Osteocytes are Mechanosensors in the Inhibition of Bone Resorption due to Mechanical Loading. Proc Soc Physical Regulation in Medicine and Biology, p. 56 January, 2006.

You, L., Temiyasathit, C., Lee, P., Kim, C.H., Tummala, P., Yao, W., Kingery W., Jacobs. C., Osteocytes as Mechanosensors in the Inhibition of Bone Resorption due to Mechanical Loading. Transactions of the Orthopaedic Research Society, p. 382, March 2006.

Conference Presentations and Abstracts - Prior to 2006

Batra NN, Li YJ, Yellowley CE, You L, Jacobs CR. Short term recovery periods lead to multiple oscillatory fluid flow induced intracellular calcium oscillations in osteoblastic cells. Proc ASME Summer Bioeng Conf, p 705, 2003.

Jair KY, Batra NN, You L, Jacobs CR. Dynamics of F-actin cytoskeleton reorganization under loading-induced oscillatory fluid flow in MC3T3-E1 pre-osteoblasts. Proc ASME Summer Bioeng Conf, p 697, 2003.

You L, Li YJ, Batra NN, Jacobs CR. The effect of oscillatory fluid flow on human marrow stomal cell proliferation. Proc ASME Summer Bioeng Conf, p 267, 2003.

You L, Li YJ, Batra NN, Jacobs CR. Design of a 3D Microfluidic system for loading fluid flow on osteocyte processes in vitro. Proc ASME Summer Bioeng Conf, p 695, 2003.

L. You, S.C. Cowin, M.B. Schaffler, S. Weinbaum, Fluid flow induced strain amplification in bone cells, International Sun Valley Hard Hard Tissue Workshop, 2001.

L. You, S.C. Cowin, M.B. Schaffler, S. Weinbaum, Fluid flow induced strain amplification in bone cells, 47th Annual Meeting of Orthopaedic Research Society, San Francisco, 2001.

L. You, S.C. Cowin, M.B. Schaffler, S. Weinbaum, Strain amplification in bone, Annual Fall Meeting of the Biomedical Engineering Society, Seattle, 2000.

L. You, S.C. Cowin, M.B. Schaffler, S. Weinbaum, A Potential Mechanism for Mechanotransduction in Bone: Fluid flow Induced Strain Amplification on Bone Cells, Second Bone Fluid Workshop, New York, 2000.

L.You, S.C. Cowin, S. Weinbaum, Strain Amplification in the Bone Mechanosensory System, The First Joint BMES/EMBS Conference, Atlanta, 1999.

L.You, S.C. Cowin, S. Weinbaum, Strain Amplification in the Bone Mechanosensory System, International Mechanical Engineering Congress & Exposition, Nashville, 1999.

L.You, S.C. Cowin, S. Weinbaum, Strain Amplification in the Bone Mechanosensory System, PreORS Meeting , Anaheim, 1999.

Last updated 10/10/2007