Modeling of Muscle Action Potentials

We are investigating the way in which the shapes of muscle action potentials are determined by anatomical and physiological factors. This is important for accurate interpretation of clinically recorded signals. This work also provides a basis for the electrophyiological imaging of motor unit architecture.

References

Xiao SJ, McGill KC, Hentz VR. Action potentials of curved nerves in finite limbs. IEEE Trans Biomed Eng, 42: 599-607, 1995.

Lateva ZC, McGill KC, Burgar CR. Anatomical and electrophysiological determinants of the human thenar CMAP. Muscle & Nerve, 19:1457-1468, 1996. Abstract

McGill KC, Lateva ZC. Decomposition of the compound muscle action potential into source and weighting functions. 18th Ann Intl Conf IEEE Eng Med Biol Soc, 1996. Abstract

Lateva ZC, McGill KC. Estimation of the compound intracellular action potential from surface-recorded muscle signals. 18th Ann Intl Conf IEEE Eng Med Biol Soc, 1996. Abstract

Lateva ZC, McGill KC. The physiological nature of the slow afterwave in muscle action potentials. 14th Ann Congr Electroenceph Clin Neurophysiol, 1997. Abstract

McGill KC, Lateva ZC. Why do MUAPs from long and short muscles have similar durations? Am Assoc Electrodiagnostic Med Ann Sci Mtg, 1997. Abstract

Lateva ZC, McGill KC. Mapping of surface potential fields of thenar and hypothenar CMAPs. Am Assoc Electrodiagnostic Med Ann Sci Mtg, 1997. Abstract

McGill KC, Lateva ZC. The contribution of the interosseous muscles to the hypothenar CMAP. Muscle & Nerve, 22: 1-10, 1999. Abstract

Lateva ZC, McGill KC. Electromyographic imaging of motor-unit architectural properties. Proc 12th Intl Soc Electromyogr Kinesiol (ISEK) Congr, 1998. Abstract

Lateva ZC, McGill KC. The physiological origin of the slow afterwave in muscle action potentials. Electroencephalogr Clin Neurophysiol, 109: 462-469, 1998. Abstract

Lateva ZC, McGill KC. Satellite potentials of motor unit action potentials in normal muscles: a new hypothesis for their origin. Clin Neurophysiol, 110: 1625-1633, 1999. Abstract

Lateva ZC, McGill KC. Estimation of motor-unit properties by morphological analysis of motor-unit action potential waveforms. 11th Intl Congr Electromyogr Clin Neurophysiol, Prague, Czech Republic, 1999. Abstract

McGill KC, Lateva ZC. Slow repolarization phase of the intracellular action potential influences the motor unit action potential. Muscle & Nerve, 23: 826-827, 2000.

Lateva ZC, McGill KC. Estimating motor-unit architectural properties by analyzing motor-unit action potential morphology.Cin Neurophysiol, 112: 127-135, 2001. Abstract

McGill KC, Lateva ZC, Xiao S. Models of the leading edge, terminal wave, and slow afterwave of the muscle action potential. IEEE Trans Biomed Eng, in review. Abstract

McGill KC, Lateva ZC. A model of the muscle-fiber intracellular action potential waveform, including the slow-repolarization phase. IEEE Trans Biomed Eng, in review. Abstract