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Publications and Presentations

Peer Reviewed Articles

Chiu R, Ma T, Smith RL, Goodman SB. Polymethylmethacrylate particles inhibit osteoblastic differentiation of bone marrow osteoprogenitor cells. Journal of Biomedical Materials Research A, 77:850-856, 2006.

Li KW, Lindsey DP, Wagner DR, Giori NJ, Schurman DJ, Goodman SB, Smith RL, Carter DR, Beaupré GS: Gene Regulation Ex Vivo within a Wrap-Around Tendon. Tissue Engineering, 12(9):2611-8, 2006.

Miyanishi K, Trindada MCD, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL: Effects of hydrostatic pressure and transforming growth factor-beta3 on adult human mesenchymal stem cell chondrogenesis in vitro. Tissue Engineering, 12(6):1419-1428, 2006.

Miyanishi K, Trindada MCD, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL: Dose- and time-dependent effects of cyclic hydrostatic pressure on Transforming Growth Factor-beta3-induced chondrogenesis by adult human mesenchymal stem cells in vitro. Tissue Engineering, 12(8):2253-2262, 2006.

Ramachandran R., Goodman SB, Smith RL. The effects of titanium and polymethylmethacrylate particles on osteoblast phenotypic stability. Journal of Biomedical Materials Research A, 77:512-517, 2006.

Spangole JP, Miyanishi K, Ma T, Epstein NJ, Smith RL, Goodman SB. Comparison of VEGFproducing cells in periprosthetic osteolysis. Biomaterials, 27:3882-3887, 2006.

Andriacchi TP, Mundermann A, Smith RL, Alexander EJ, Dyrby CO, and Koo S: A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng. 32:447-457, 2004.

Carter DR, Beaupré GS, Wong M, Smith RL, Andriacchi TP, Schurman DJ, and Smith RL: The mechanobiology of articular cartilage development and degeneration. Clin Orthop Relat Res. Oct(427 Suppl):S69-77, 2004.

Carter DR, Beaupré GS, Wong M, Smith RL, Andriacchi TP, and Schurman DJ: The mechanobiology of articular cartilage development and degeneration. Clin Orthop Rel Res, 427S:S69-S77, 2004.

Goodman SB, Trindade M, Ma T, Genovese M, and Smith RL: Pharmacologic modulation of periprosthetic osteolysis. Clin Orthop Relat Res. 2005 Jan(430):39-45, 2005.

Li KW, Lindsey DP, Wagner DR, Giori NJ, Schurman DJ, Goodman SB, Smith RL, Carter DR, and Beaupré GS: Gene Regulation Ex Vivo Within a Wrap-Around Tendon. Submitted to Tissue Engineering on June 7, 2005, currently being revised.

Schurman DJ and Smith RL: Osteoarthritis: current treatment and future prospects for surgical, medical, and biologic intervention. Clin Orthop Relat Res. Oct(427 Suppl):S183-189, 2004.

Smith, RL, Carter DR, and Schurman DJ: Pressure and shear differentially alter human articular chondrocyte metabolism: a review. Clin Orthop Relat Res. 2004 Oct(427 Suppl):S89-95, 2004.

Ma T, Miyanishi K, Trindade MC, Genovese M, Regula D, Smith RL, Goodman SB. Interleukin 1 receptor antagonist inhibits localized bone formation in vivo. J Rheumatol, 30: 2547-52, 2003.

Ma T, Miyanishi K, Suen A, Epstein NJ, Tomita T, Smith RL, Goodman SB. Human interleukin-1-induced murine osteoclastogenesis is dependent on RANKL, but independent of TNF-alpha. Cytokine, 26:138-44, 2004.

Trindade MC, Shida J, Ikenoue T, Lee MS, Lin EY, Yaszay B, Yerby S, Goodman SB, Schurman DJ, Smith RL. Intermittent hydrostatic pressure inhibits matrix metalloproteinase and pro-inflammatory mediator release from human osteoarthritic chondrocytes in vitro. Osteoarthritis Cartilage, 12: 729-35, 2004.

Warme BA, Epstein NJ, Trindade MC, Miyanishi K, Ma T, Saket RR, Regula D, Goodman SB, Smith RL. Proinflammatory mediator expression in a novel murine model of titanium-particle-induced intramedullary inflammation. J Biomed Mater Res, 71B: 360-6, 2004.

Wong N, Trindade MC, Patel R, Yaszay B, Goodman SB, Smith RL. Effects of interleukin-10 on titanium particle-induced macrophage transcription factor activation and cytokine expression in vitro. J Biomed Mater Res A, 69: 40-6, 2004.

Arora A, Song Y, Chun L, Huie P, Trindade MCD, Smith RL, Goodman SB. The role of the TH1 and TH2 immune response in loosening and osteolysis of total hip replacements. J Biomed Mater Res, 64A: 693-697, 2003.

Goodman SB, Song Y, Yoo JY, Fox N, Trindade MCD, Kajiyama G, Ma T, Regula D, Brown J, Smith RL. Local infusion of FGF-2 enhances bone ingrowth in rabbit chambers in the presence of polyethylene particles. J Biomed Mater Res, 65A: 454-461, 2003.

Goodman SB, Trindade MCD, Ma T, Lee M, Wang N, Ikenou T, Matsuura I, Miyanishi K, Fox N, Regula D, Genovese M, Klein J, Bloch D, Smith RL. Modulation of bone ingrowth and tissue differentiation by local infusion of interleukin-10 in the presence of ultra-high molecular weight polyethylene (UHMWPE) wear particles. J Biomed Mater Res, 65A: 43-50, 2003.

Ikenoue T, Trindade MCD, Lee MS, Lin EY, Schurman DJ, Goodman SB, Smith RL. Mechanoregulation of human articular chondrocyte aggrecan and type II collagen expression by intermittent hydrostatic pressure in vitro. J Orthop Res, 21: 110-116, 2003.

Lee MS, Trindade MCD, Ikenoue T, Goodman SB, Schurman DJ, Smith RL. Regulation of nitric oxide and bcl-2 expression by shear stress in human osteoarthritic chondrocytes in vitro. J Cellular Biochem, 90: 80-86, 2003.

Lee MS, Trindade MCD, Ikenoue T, Schurman DJ, Goodman SB, Smith RL. Intermittent hydrostatic pressure inhibits shear stress-induced nitric oxide release in human osteoarthritic chondrocytes in vitro. J Rheumatol, 30: 326-328, 2003.

Lee MS, Ikenoue T, Trindade MCD, Wong N, Goodman SB, Schurman DJ, Smith RL. Protective effects of intermittent hydrostatic pressure on osteoarthritic chondrocytes activated by bacterial endotoxin in vitro. J Orthop Res, 21: 117-122, 2003.

Miyanishi K, Trindade MCD, Ma T, Goodman SB, Schurman DJ, Smith RL. Periprosthetic osteolysis: induction of vascular endothelial growth factor from human monocyte/macrophages by orthopaedic biomaterial particles. J Bone Mineral Res, 18: 1573-1583, 2003.

Puskas BL, Menke NE, Huie P, Song Y, Ecklund K, Trindade MCD, Smith RL, Goodman SB. Expression of nitric oxide, peroxynitrite, and apoptosis in loose total hip replacements. J Biomed Mater Res, 66A: 541-549, 2003.

Sun DH, Trindade MCD, Nakashima Y, Maloney WJ, Goodman SB, Schurman DJ, Smith RL. Human serum opsonization of orthopaedic particles: protein-binding and monocyte/macrophage activation in vitro. J Biomed Mater Res, 65A: 290-298, 2003.

Goodman S, Ma T, Trindade M, Ikenoue T, Matsuura I, Wong N, Fox N, Genovese M, Regula D, Smith RL. COX-2 selective NSAID decreases bone ingrowth in vivo. J Orthop Res, 20: 1164-1169, 2002.

van der Meulen MCH, Beaupré GS, Smith RL, Giddings VL, Allen WA, Athanasiou KA, Zhu CF, Mandell JA, Song Y, Poser RD, Goodman SB.Factors influencing changes in articular cartilage followinghemiarthroplasty in sheep. J Orthop Res, 20: 669-675, 2002.

Trindade MC, Lind M, Nakashima Y, Sun D, Goodman SB, Schurman DJ, Smith RL. Interleukin-10 inhibits polymethylmethacrylate particle induced interleukin-6 and tumor necrosis factor-alpha release by human monocyte/macrophages in vitro. Biomaterials, 22: 2067-2073, 2001.

Trindade MC, Lind M, Sun D, Schurman DJ, Goodman SB, Smith RL. In vitro reaction to orthopaedic biomaterials by macrophages and lymphocytes isolated from patients undergoing revision surgery. Biomaterials, 22: 253-259, 2001.

Yaszay B, Trindade MCD, Lind M, Goodman SB, Smith RL. Fibroblast expression of C-C chemokines in response to orthopaedic biomaterial particle challenge in vitro. J Orthop Res, 19: 970-976, 2001.

Smith RL, Lin J, Trindade MCD, Shida J, Kajiyama G, Vu T, Hoffman AR, van der Meulen MCH, Goodman SB, Schurman DJ, Carter DR: Time-dependent effects of intermittent hydrostatic pressure on articular chondrocyte type II collagen and aggrecan mRNA expression. J Rehab R&D, 37:153-161, 2000.
http://www.vard.org/jour/00/37/2/smith372.htm

Lind M, Trindade MC, Schurman DJ, Goodman SB, Smith RL: Monocyte migration inhibitory factor synthesis and gene expression in particle-activated macrophages. Cytokine, 12:909-913, 2000.

Shida J, Trindade MC, Goodman SB, Schurman DJ, Smith RL: Induction of interleukin-6 release in human osteoblast-like cells exposed to titanium particles In vitro. Calcif Tissue Int, 67:151-155, 2000.

Trindade MC, Schurman DJ, Maloney WJ, Goodman SB, Smith RL: G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro. J Biomed Mater Res, 51:360-368, 2000.

Trindade MCD, Lind M, Sun D-H, Schurman DJ, Goodman SB, Smith RL: In Vivo Reaction to Orthopaedic Biomaterials by Macrophages and Lymphocytes Isolated from Patients Undergoing Revision Surgery. In Press, Biomaterials, 2000.

Goodman S, Song Y, Chun L, Aspenberg P, Plouhar P, Glancy T, Regula D, Smith RL. Effects of local infusion of TGF-beta on bone ingrowth in rabbit chambers. J Biomed Material Res, 53: 475-479, 2000.

Schurman DJ, Maloney WJ, Smith RL. Localized osteoporosis. In Osteoporosis (eds: Marcus R, Feldman D). Academic Press, New York, 2001.

Smith LR, Trindade MC, Ikenoue T, Mohtai M, Das P, Carter DR, Goodman SB, Schurman DJ. Effects of shear stress on articular chondrocyte metabolism. Biorheology, 37: 95-107, 2000.

Nakashima Y, Sun DH, Chun LE, Trindade M, Song Y, Maloney WJ, Goodman SB, Schurman DJ, Smith RL. Expression of C-C Chemokines by Human Macrophages in Response to Particles of Orthopaedic Biomaterials In Vitro. J Bone Joint Surg, 81-B:155-162, 1999.

Trindade MCD, Song Y, Aspenberg P, R. Lane Smith, Goodman SB: Proinflammatory Mediator Release in Response to Particle Challenge: Studies Using the Bone Harvest Chamber. J Biomed Mater Res, 48:434-439, 1999.

Trindade MCD, Lind M, Goodman SB, Maloney WJ, Schurman DJ, Smith RL: Interferon-gamma Exacerbates Polymethylmethacrylate Particle-Induced Interleukin-6 Release by Human Monocyte/Macrophages In Vitro. J Biomed Mater Res, 47:1-7, 1999.

Trindade MCD, Nakashima Y, Lind M, Sun DH, Maloney WJ, Goodman SB, Schurman DJ, Smith RL: Interleukin-4 Inhibits Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-6 and Tumor Necrosis Factor-alpha Expression by Human Monocytes in Response to Polymethacrylate Particle Challenge In Vitro. J Orthop Res, 17:797-802, 1999.

Sacoman D, Smith R Lane, Song Y, Fornasier V, Goodman SB: The Effects of Polyethylene Particles on Tissue Surrounding Knee Arthroplasties in Rabbits. J Biomed Mater Res, 43:123-130, 1998.

Smith, R. Lane; Kajiyama G.; Schurman, D.J.: Staphylococcal Septic Arthritis: Antibiotic and Nonsteroidal Antiinflammatory Drug Treatment in a Rabbit Model. J Orthop Res, 15:919-926, 1998.

Nakashima Y.; Sun, D.H.; Maloney W.J.; Goodman S.B.; Schurman D.J.; Smith R. Lane: Orthopaedic Wear Debris and Matrix Metalloproteinase Expression in Human Macrophages In Vitro. J Bone Jt Surg, 80-B:694-700, 1998.

Maloney, W.J.; Sun, D.H.; Nakashima, Y.; James, R.; Smith, R. Lane: Effects of Serum Protein Opsonization on Cytokine Release by Titanium Alloy Particles. J Biomed Mater Res, 41:371-376, 1998.

Lind M.; Trindade M.C.D.; Yaszay B.; Goodman, S.B.; Smith, R. Lane: Effects of Particulate Debris on Macrophage-Dependent Fibroblast Stimulation in Coculture. J Bone and Joint Surgery, 80-B: 924-930, 1998.

DeGraw, J.I.; Colwell, W.T.; Crase, J.; Smith, R. Lane; Piper, J.R.; Waud, W.R.; Sirotnak, F.M.: Analogues of Methotrexate in Rheumatoid Arthritis. 1. Effects of 10-Deazaaminopterin Analogues on Type II Collagen-Induced Arthritis in Mice. J Med Chem, 40:370-376. 1997.

Piper, J.R.; DeGraw, J.I.; Colwell, W.T.; Johnson, C.A.; Smith, R. Lane; Waud, W.R.; Sirotnak, F.M.: Analogues of Methotrexate in Rheumatoid Arthritis. 2. Effects of 5-Deazaaminopterin and 5,10-Dideazaaminopterin and Analogues on Type II Collagen-Induced Arthritis in Mice. J Med Chem, 40:377-384, 1997.

Das, P.; Schurman, D.J.; Smith, R. Lane: Nitric Oxide and G Proteins Mediate the Response of Bovine Articular Chondrocytes to Flow-Induced Shear. J Orthop Res, 15:87-93, 1997.

Tsuchiya, K.; Maloney, W. J.; Vu T.; Hoffman, A.R; Huie, P.; Schurman, D.J.; Smith, R. Lane: Osteoarthritis: Differential Expression of Matrix Metalloproteinase-9 mRNA in Non-Fibrillated and Fibrillated Cartilage. J Orthop Res, 15:94-100, 1997.

Degraw, J.I.; Almquist, R.G.; Hiebert, C.K.; Colwell, W.T.; Crase, J.; Hayano, T., Judd, A.K.; Dousman, L.; Smith, R. Lane; Waud, W.R., Uchida, I.: Stabilized Analogs of Thymopentin. 1. 4,5-Ketomethylene-Pseudopeptides. J. Med Chem, 40:2386-2397, 1997.

Degraw JI, Almquist RG, Hiebert CK, Judd AK, Dousman L, Smith RL,Waud WR, Uchida I: Stabilized Analogs of Thymopentin. 2. 1,2 and 3,4- Ketomethylene-Pseudopeptides. J Med Chem, 40:2398-2406, 1997.

Smith, R. Lane; Dousman, L.; Waud, W.R.; DeGraw, J.I.: Stabilized Analogs of Thymopentin. 3. Evaluation of Ketomethylene-Pseudopeptides for Antiarthritic Properties. J. Med Chem, 40:2407-2411, 1997.

Mohtai M, Gupta MK, Donlon B, Ellison B, Cooke J, Gibbons G, Schurman DJ, Smith R. Lane: Interleukin-6 (IL-6) Expression in Osteoarthritic Chondrocytes and Effects of Fluid-Induced Shear on IL-6 Expression in Normal Human Chondrocytes In Vitro. J Orthop Res, 14:67-73, 1996.

Maloney WJ, James RE, Smith R Lane: Human Macrophage Response to Retrieved Titanium Alloy Particles In Vitro. Clinical Orthopaedics, 322:268-278, 1996.

Smith R Lane, Rusk SF, Ellison BE, Wessells P, Tsuchiya K, Carter DR, Caler WE, Sandell LJ, Schurman DJ: In Vitro Stimulation of Articular Chondrocyte mRNA and Extracellular Matrix Synthesis by Hydrostatic Pressure. J Orthop Res, 14:67-73, 1996.

Pullin JG, Collier MA, Das P, Smith R Lane, DeBault LE, Johnson LL, Walls RC: Effects of Holmium:YAG Laser Energy on Cartilage Metabolism, Healing and Biochemical Properties of Lesional and Perilesional Tissue in a Weight Bearing Model. J. Arthroscopic and Rel Surg, 12:15-25, 1996.

Gonzalez O, Smith R Lane, Goodman SB: Effect of Size, Concentration, Surface Area and Volume of Polymethylmethacrylate Particles on Human Macrophages In Vitro. J Biomed Mat Res, 30:463-473, 1996.

Olney RC, Tsuchiya K, Wilson DM, Mohtai M, Maloney WJ, Schurman DJ, Smith R Lane: Chondrocytes from Osteoarthritic Cartilage Have Increased Expression of Insulin-like Growth Factor (IGF-I) and IGF-Binding Protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4. J. Clinical Endocrinology and Metabolism, 81:1096-1103, 1996.

Tsuchiya K, Maloney WJ, Vu T, Hoffman AR, Schurman DJ, Smith R Lane: RT-PCR Analysis of MMP-9 Expression in Human Articular Cartilage Chondrocytes and Synovial Fluid Cells. Biotechnic and Histochem, 71:208-213, 1996.

Manlapaz M.; Maloney, W.J.; Smith, R. Lane: In Vitro Activation of Human Fibroblasts by Retrieved Titanium Alloy Wear Debris. J Orthop Res., 14:465-472, 1996.

Miller JJ, Zhu S, Smith, RL: Anti-Lipid A Antibodies in Childhood Arthritis: Methods of Immobilization Affect Quantitation and Cross-Reactivity Measured by ELISA. J Rheumatol, 23:2125-2131, 1996.

Kornu R, Maloney WJ, Kelly MA, Smith R Lane: Osteoblast Adhesion to Orthopaedic Implant Alloys: Effects of Cell Adhesion Molecules and Diamond-Like Carbon Coating. J Orthop Res, 14:871-877, 1996.

Olney RC, Mohtai M, Wilson DM, Smith R. Lane: The Effect of Interleukin-1 and Tissue Necrosis Factor Alpha on Insulin-Like Growth Factor Binding Protein Production in Human Articular Chondrocytes. J Endocrinology, 146:279-286, 1995.

Smith R Lane, Gupta MK, Donlon B, Masaaki M, Ellison B, Gibbons G, Cooke J, Schurman DJ: Effects of Fluid-Induced Shear on Articular Chondrocyte Morphology and Metabolism, J Orthop Res, 13:824-831, 1995.

Conference Presentations and Abstracts

Agarwal A, Lindsey DP, Thomas R, Longaker MT, Smith RL, Carter DR, and Beaupré GS: Mechanosensitivity of MSCs to cyclic pressure or stretch in a collagen I scaffold. Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, Vol 29:844, 2004.

Chiu R, Ma T, Smith RL, and Goodman SB: PMMA particles inhibit osteoblastic development of bone marrow osteoprogenitor cells. Transactions of the 51st Annual Meeting of the Orthopaedic Research Society, Vol 30:1076, 2005.

Epstein NJ, Warme BA, Spanogle J, Ma T, Bragg B, Smith RL, and Goodman SB. Interleukin-1 modulates periprosthetic tissue formation in an intramedullary model of particle-induced inflammation. 23:501-10, 2005.

Epstein NJ, Bragg WE, Ma T, Spanogle J, Smith RL, and Goodman SB. UHMWPE wear debris upregulates mononuclear cell proinflammatory gene expression in a novel murine model of intramedullary particle disease. Acta Orthop 76:412-420, 2005.

Fong KD, Trindade MC, Wang Z, Nacamuli RP, Pham H, Fang TD, Song HM, Smith RL, Longaker MT, and Chang J: Microarray analysis of mechanical shear effects on flexor tendon cells. Plast Reconstr Surg 116:1393-404, 2005.

Goodman SB, Ma T, Miyanishi K, Suen A, Genovese M, and Smith RL: Inhibition of bone ingrowth by a cox-2 selective NSAID is reversible. Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, Vol 29:1419, 2004.

Goodman SB, Ma T, Spanogle J, Chiu R, Miyanishi K, Suen A, Oh KJ, Plouhar P, Wadsworth S, and Smith RL: Persistant polyethylene particle-induced suppression of bone ingrowth with concurrent oral P-38 MAP kinase inhibitor. Transactions of the 51st Annual Meeting of the Orthopaedic Research Society, Vol 30:1137, 2005.

Goodman SB, Ma T, Mitsunaga L, Miyanishi K, Genovese MC, and Smith RL: Temporal effects of a COX-2-selective NSAID on bone ingrowth. J Biomed Mater Res A 72:279-87, 2005.

Li KL, Linsey DP, Wagner DR, Giori NJ, Schurman DJ, Goodman SB, Smith RL, Carter DR, and Beaupré GS: Mechanobiologic influences on tissue-engineered tendon implants in vitro. Transactions of the 51st Annual Meeting of the Orthopaedic Research Society, Vol 30:399, 2005.

Li KL, Lindsey DP, Wagner DR, Giori NJ, Schurman DJ, Goodman SB, Smith RL, Carter DR, and Beaupré GS: Mechanobiological influences on tissue-engineered tendon implants in vitro. Trans Orthop Res Soc 30:399, 2005.

Ma T, Miyanishi K, Suen A, Epstein NJ, Tomita T, Smith RL, and Goodman SB: Human interleukin-1-induced murine osteoclastogenesis is dependent on RANKL, but independent of TNF-alpha. Cytokine 26:138-44, 2004.

Ma T, Chiu R, Smith RL, and Goodman SB: Inhibition of murine bone marrow cell osteogenesis by interleukin-1 alpha. Transactions of the 51st Annual Meeting of the Orthopaedic Research Society, Vol 30:858, 2005.

Mawatari T, Miura H, Hami S, Shuto T, Nakashima Y, Yamada H, Okazaki K, Smith RL, and Iwamoto Y: Effect of alendronate and vitamin K2 on 3-D microarchitecture of osteoporotic spine in rheumatoid arthritis patient in vivo. Transactions of the 51st Annual Meeting of the Orthopaedic Research Society, Vol 30:1130, 2005.

Miyanishi K, Trindade MCD, Lindsey DP, Goodman SB, Schurman DJ, Beaupré GS, Carter DR, and Smith RL: Intermittent hydrostatic pressure upregulates endogenous transforming growth factor 1 and 3 gene expression in human mesenchymal stem cells. Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, Vol 29:636, 2004.

Miyanishi K, Trindade MCD, Lindsey DP, Goodman SB, Schurman DJ, Beaupré GS, Carter DR, and Smith RL: Mechanoregulation of chondrogenic gene exrpression in human mesenchymal stem cells. Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, Vol 29:836, 2004.

Smith RL, Linsey DP, Dhulipala L, Goodman SB, and Schurman DJ: Effects of mechanical loading and BMP-2 on human OA chondrocytes in vitro. 5th Combined Meeting of the Orthopaedic Research Societies of Canada, USA, Japan and Europe, #267, October 2004.

Smith RL, Lindsey DP, Dhulipala L, Mawatari Goodman SB, and Schurman DJ: Insulin Modulation of human osteoarthritic chondrocyte metabolism and matrix protein gene expression. Transactions of the 51st Annual Meeting of the Orthopaedic Research Society, Vol 30:1455, 2005.

Trindade MCD, Shida J-I, Ikenoue T, Lee MS, Lin EY, Yaszy B, Yerby S, Goodman SB, Shurman DJ, and Smith RL: Intermittent hydrostatic pressure inhibits matrix metalloproteinase and pro-inflammatory mediator release form human osteoarthritic chondrocytes in vitro. Osteoarthritis Cartilage 12:729-735, 2004.

Warme BA, Epstein NJ, Trindade MC, Miyanishi K, Ma T, Saket RR, Regula D, Goodman SB, and Smith RL: Proinflammatory mediator expression in a novel murine model of titanium-particle-induced intramedullary inflammation. J Biomed Mater Res. 71B:360-366, 2004.

Wong N, Trindade MC, Patel R, Yaszay B, Goodman SB, and Smith RL: Effects of interleukin-10 on titanium particle-induced macrophage transcription factor activation and cytokine expression in vitro. J Biomed Mater Res 69A:40-46, 2004.

Ma T, Miyanishi K, Trindade MCD, Genovese M, Regula D, Smith, RL, Goodman SB. IL-1 receptor antagonist inhibits tissue ingrowth in vivo. Trans 49th Ann Mtg Orthop Res Soc, 28: 1368, 2003.

Miyanishi K, Trindade MCD, Ma T, Goodman SB, Schurman DJ, Smith RL. Human monocyte-derived vascular endothelial growth factor and orthopaedic implant osteolysis. Trans 49th Ann Mtg Orthop Res Soc, 28: 1448, 2003.

Trindade MCD, Miyanishi, K, Goodman SB, Schurman DJ, Smith RL. Shear stress increases human osteoarthritic chondrocyte VEGF release in vitro through activation of the transcription factor, HIF-1 and MAPK. Trans 49th Ann Mtg Orthop Res Soc, 28: 632, 2003.

Goodman SB, Ma T, Ikenoue T, Matsura I, Trindade MCD, Fox N, Wang N, Genovese M, Smith RL. Cox-2 selective NSAID decreases bone ingrowth in vivo. Trans 48th Ann Mtg Orthop Res Soc, 27: 2002.

Goodman SB, Ma T, Trindade MCD, Ikenoue T, Matsura I, Regula D, Genovese M, Bloch D, Smith RL. Local infusion of IL-10 mitigates suppression of bone ingrowth due to UHMWPE wear particles. Trans 48th Ann Mtg Orthop Res Soc, 27: 2002.

Goodman SB, Ma T, Trindade MCD, Ikenoue T, Matsura I, Regula D, Genovese M, Bloch D, Smith RL. Suppression of bone ingrowth due to UHMWPE wear particles is mitigated by local infusion of interleukin-10. Trans 28th Annual Mtg Soc Biomaterials, 25: 267, 2002.

Goodman SB, Ma T, Ikenoue T, Matsura I, Trindade MCD, Fox N, Wang N, Genovese M, Regula D, Smith RL. Suppression of bone ingrowth by a COX-2 selective NSAID in vivo. Trans 28th Ann Mtg Soc Biomaterials, 25: 690, 2002.

Lin EY, Smith RL. Gene expression profiling of the osteoarthritic chondrocyte response to mechanical loading. Trans 48th Ann Mtg Orthop Res Soc, 27: 2002.

Smith RL, Lin EY, Trindade MCD, Ikenoue T, Lee MS, Goodman SB, Schurman DJ. Effects of intermittent hydrostatic pressure on osteoarthritic chondrocyte extracellular matrix phenotype in vitro. Trans 4th Intl Cartilage Repair Soc Symp, 4: 160, 2002.

Trindade MCD, Miyanishi, K, Goodman SB, Schurman DJ, Smith RL. Shear stress increases human osteoarthritic chondrocyte VEGF release in vitro. Trans 4th Intl Cartilage Repair Soc Symp, 4: 249, 2002.

Arora A, Song Y, Chun L, Huie P, Trindade M, Smith RL Goodman SB. The role of the TH1 and TH2 immune response in loosening and osteolysis of total hip replacements. Trans 27th Ann Mtg Soc Biomaterials, p 299, 2001.

Goodman SB, Lee M, Trindade MCD, Fox N, Ma T, Regula D, Genovese M, Klein J, Bloch D, Smith RL. Modulation of bone ingrowth and tissue differentiation by local infusion of IL-10 in the presence of UHMWPE wear particles. Trans 27th Ann Mtg Soc Biomaterials, p 219, 2001.

Ikenoue T, Lee M, Trindade MCD, Schurman D, Goodman S, Smith RL. Effects of intermittent hydrostatic pressure on matrix protein expression in normal human chondrocytes. Ann Mtg Soc Physical Regulation in Biology and Medicine, 2001.

Ikenoue T, Lee M, Trindade MCD, Schurman D, Goodman S, Smith RL. Effects of intermittent hydrostatic pressure on normal human chondrocytes. Trans 47th Ann Mtg Orthop Res Soc, 26: 550, 2001.

Lee M, Ikenoue T, Trindade MCD, Wang N, Goodman SB, Schurman DJ, Smith RL. Cartilage matrix protein expression: effects of intermittent hydrostatic pressure on nitric oxide suppression of chondrocyte mRNA levels. Trans 20th Ann Mtg Soc Physical Regulation in Biology and Medicine, 2001.

Lee M, Ikenoue T, Trindade MCD, Wang N, Goodman SB, Schurman DJ, Smith RL. Intermittent hydrostatic pressure counteracts inhibitory effects of nitric oxide on chondrocyte matrix protein mRNA expression in vitro. Trans 47th Ann Mtg Orthop Res Soc, 26: 560, 2001.

Lee M, Ikenoue T, Trindade MCD, Wang N, Goodman SB, Schurman DJ, Smith RL. Human osteoarthritic chondrocytes are susceptible to shear stress and undergo apoptosis. Trans 47th Ann Mtg Orthop Res Soc, 26: 561, 2001.

Shah SN, Trindade MCD, Goodman, Schurman DJ, Smith RL. Interleukin-4 (IL-4) reduces expression of IL-1 and IL-6 in tissue harvested from failed total joint arthroplasties. Trans 27th Ann Mtg Soc Biomaterials, p 218, 2001.

Trindade MCD, Ikenoue T, Lee M, Lin E, Shah S, Goodman SB, Schurman DJ, Smith RL. Intermittent hydrostatic pressure inhibits matrix metalloproteinase-2 release from human osteoarthritic chondrocytes in vitro. Trans 47th Ann Mtg Orthop Res Soc, 26: 457, 2001.

Trindade MCD, Lee M, Ikenoue T, Goodman SB, Schurman DJ, Smith RL. Fluid induced shear stress increases human osteoarthritic chondrocyte pro-inflammatory mediator release in vitro. Trans 47^th Ann Mtg Orthop Res Soc, 26: 551, 2001.

Yaszay B, Trindade MCD, Goodman SB, Smith RL. Fibroblast expression of MIF I response to PMMA and titanium particle challenge in vitro. Trans 27th Ann Mtg Soc Biomaterials, p 428, 2001.

Yerby SA, Beaupré GS, Young PM, Smith RL, Sims GE. The effect of shock wave therapy at the bone/screw interface. Trans Orthop Res Soc, 26: 976, 2001.

Goodman S, Song Y, Yoo JY, Trindade M, Kajiyama G, Fox N, Klein J, Brown, J, Regula D, Smith RL. Local infusion of fibroblast growth factor mitigates polyethylene particle-induced suppression of bone ingrowth. Trans 6th World Congr Biomaterials, 1: 188, 2000.

Goodman SB, Song Y, Chun L, Fox N, Aspenberg P, Regula D, Smith RL. Exogenous TGF-beta enhances net bone formation by downregulating IL-1beta production in rabbit bone chambers containing polyethylene particles. Trans 6th World Congr Biomaterials, 2: 488, 2000.

Shah SN, Trindade MCD, Goodman SB, Schurman DJ, Smith RL. Periprosthetic bone resorption: effects of granulomatous tissue on alkaline phosphatase release from frozen-thawed cortical bone fragments. Trans 6th World Congr Biomaterials, 3: 887, 2000.

Trindade MCD, Schurman DJ, Maloney WJ, Goodman SB, Smith RL. G-protein activity requirement for polymethylmethacrylate and titanium particle induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro. Trans 6th World Congr Biomaterials, 1: 381, 2000.

Trindade MCD, Shida JI, Ikenoue T, Lee MS, Yerby SA, Goodman SB, Schurman DJ, Smith RL. Intermittent hydrostatic pressure inhibits IL-6 and MCP-1 expression by human osteoarthritic chondrocytes cultured on polystyrene in vitro. Trans 6th World Congr Biomaterials, 3: 949, 2000.

Cartilage Repair and Regeneration: Effects of Mechanical Loading on Osteoarthritic Cartilage Cell Metabolism, 2nd National Rehabilitation Research and Development Service Meeting, Arlington, VA, February 20-22, 2000.
Abstract

In Press - 2006

Li KW, Lindsey DP, Wagner DR, Giori NJ, Schurman DJ, Goodman SB, Smith RL, Carter DR, Beaupré GS: Gene Regulation Ex Vivo Within a Wrap-Around Tendon. In Press: Tissue Engineering,12(9), 2006.

Miyanishi K, Trindada MCD, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL: Effects of hydrostatic pressure and transforming growth factor-beta3 on adult human mesenchymal stem cell chondrogenesis in vitro. Accepted: Tissue Engineering.

Abstracts - 2006

Chiu R, Ma T, Smith R, Goodman S. Differentiating osteoprogenitors are susceptible to irreversible inhibition by polymethylmethacrylate particles during the proliferation stage. Trans Orthop Res Soc, 31:0982, 2006.

Epstein N, Jones M, Smith R, Goodman S. Osteopontin response to UHMWPE particles is independent of monocyte chemoattractant protein-1. Trans Orthop Res Soc, 31:0702, 2006.

Li KW, Lindsey DP, Wagner DR, Giori NJ, Schurman DJ, Goodman SB, Smith RL, Carter DR, Beaupré GS: Mechanobiological influences on tissue-engineered tendon implants in vitro. Trans Orthop Res Soc 30:399, 2005.

Li KW, Lindsey DP, Wagner DR, Giori NJ, Schurman DJ, Goodman SB, Smith RL, Carter DR, Beaupré GS: Gene Regulation Ex Vivo Within a Wrap-Around Tendon. Conditionally accepted to: Tissue Engineering, June, 2005.

Ma T, Nelson E, Mawatari T, Oh K, Larsen M, Smith R, Goodman S. Effects of local infusion of OP-1 on particle or NSAID-mediated bone formation in vivo. Trans Orthop Res Soc, 31:0688, 2006.

Mawatari T, Lindsey D, Kajiyama G, Suenaga E, Goodman, D, Schurman, D, Maloney W, Smith RL. Effect of tensile strain/fluid flow on human osteoarthritic articular cartilage.

Mawatari T, Nakamichi I, Lindsey D, Kajiyama G, Suenaga E, Goodman, D, Schurman, D, Maloney W, Omary B, Smith RL. Heme oxygenase-1 in human osteoarthritic articular cartilage. Trans Orthop Res Soc, 31:1485, 2006.

Smith RL, Dhulipala L, Kajiyama G, Goodman S, Maloney W, Schurman D. Osteoarthritic chondrocyte metabolism: Effects of shear stress on interleukin-6 and nitric oxide synthase expression. Trans Orthop Res Soc, 31:1532, 2006.

Spanogle J, Smith RL, Ma T, Epstein N, Goodman S. VEGF increase in periprosthetic osteolysis is secondary to increased numbers of macrophages at the bone-implant interface. Trans Orthop Res Soc, 31:0090, 2006.

Invited Lectures

Smith RL. Mechanical regulation of articular chondrocyte metabolism. Stanford University Guidant Lecture Series, Sunnyvale, CA, Mar, 2003.

Smith RL. Cartilage repair and regeneration. Seminar, Histogenic Corporation, Malden, MA, Oct 16, 2002.

Smith RL. Intermittent hydrostatic pressure and the articular cartilage proteome. Orthopaedic Research Day, Combined Program, VA Palo Alto HCS and Stanford University, Palo Alto, CA, Sep, 2001.

Smith RL. Mechanical loading and cartilage matrix gene expression: normal human verus osteoarthritic. Founder’s Day Lectures, Division of Orthopaedics, Stanford University School of Medicine, Stanford, CA, June, 2001.

Smith RL. Mechanical stimulation of cartilage matrix gene expression. Seminar, Roche Biosciences, Palo Alto, CA, May, 2001.

Smith RL. Mechanical loading and cartilage repair and regeneration. Lecture, Am Soc Mech Eng, Orlando, FL, Nov, 2000.

Smith RL. Soluble mediators in total joint implant loosening. Total Joint Arthroplasty 2000, Am Acad Orthop Surg Workshop, Chicago, IL, Oct, 2000.

Smith RL. Hydrostatic pressure and articular cartilage repair and regeneration. Lecture, Korean Orthop Assoc Ann Mtg, Seoul, Korea, Oct, 2000.

Smith RL, Mechanical loading and cartilage metabolism. Lecture, Dept Orthopaedics, Kyushu University, Kyushu, Japan, Oct, 2000.

Smith RL. Mechanical regulation of chondrocyte metabolism. Founders Day Lectures, Division of Orthopaedics, Stanford University School of Medicine, Stanford, CA, June, 2000.

Smith RL. Articular cartilage biochemistry. Lecture, Korean Orthop Assoc Ann Mtg, Seoul, Korea, Oct, 2000.

Patents, Patent Applications, and Invention Disclosures

Smith RL, Schurman DJ, Carter DR. Method for in vivo, ex vivo, and in vitro repair and regeneration of cartilage and collagen and bone remodeling. US Patent 6,528,052, March 4, 2003.

Data Ready for Journal of Rehabilitation R&D Publication

Lin EY, Trindade MCD, Ikenoue T, Schurman DJ, Goodman SB, Smith RL. Effects of hydrostatic pressure on human articular chondrocyte gene expression and matrix deposition. J Rehab Res Dev, in preparation.

Last updated 10/10/2007