@article {cite-key,
	title = {Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea.},
	journal = {Mol Cell Biol},
	volume = {6},
	number = {10},
	year = {1986},
	month = {Oct},
	pages = {3537{\textendash}3540},
	abstract = {Long-term culturing of brain cells from neonatal BD-IX rats after transplacental treatment with N-ethyl-N-nitrosourea (ENU) results in malignantly transformed cells after a lag period of about 250 days. During culturing, the brain cells undergo a sequence of morphological changes. We examined oncogene expression in cultured cells from ENU-treated animals and found that transformed glioma cells differ from premalignant glial cells by containing high levels of c-sis transcripts. We also report that the transformed cells synthesize functional platelet-derived growth factor. Because glial cells have receptors for platelet-derived growth factor, we propose that an autocrine mechanism plays an important role in ENU-induced brain tumorigenesis.},
	issn = {0270-7306 (Print); 0270-7306 (Linking)},
	author = {Lens, P F and Altena, B and Nusse, R}
}
