@article {cite-key,
	title = {Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.},
	journal = {Mol Cell Biol},
	volume = {7},
	number = {5},
	year = {1987},
	month = {May},
	pages = {2019{\textendash}2023},
	abstract = {We investigated alterations in the structure and expression of oncogenes in mammary tumors and mammary tumor-derived cell lines. In 16 of 95 samples, we detected amplification of the human neu oncogene, also known as c-erB-2, accompanied by overexpression in the tumors from which intact RNA could be isolated. In 10 of these DNAs, the linked oncogene c-erbA was also amplified, whereas another gene on human chromosome 17, p53, was present in normal copy numbers. Overexpression of c-erbA could not be detected in the tumors analyzed. The relatively high frequency of neu amplification points to a functional role in human breast cancer. Coamplification of the c-erbA oncogene could contribute to this disease as well but is most likely fortuitous.},
	issn = {0270-7306 (Print); 0270-7306 (Linking)},
	author = {van de Vijver, M and van de Bersselaar, R and Devilee, P and Cornelisse, C and Peterse, J and Nusse, R}
}
