@article {cite-key,
	title = {Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.},
	journal = {Immunity},
	volume = {13},
	number = {1},
	year = {2000},
	month = {Jul},
	pages = {15{\textendash}24},
	address = {Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, 94143, USA.},
	abstract = {Lymphocyte enhancer factor-1 (LEF-1) is a member of the LEF-1/TCF family of transcription factors, which have been implicated in Wnt signaling and tumorigenesis. LEF-1 was originally identified in pre-B and T cells, but its function in B lymphocyte development remains unknown. Here we report that LEF-1-deficient mice exhibit defects in pro-B cell proliferation and survival in vitro and in vivo. We further show that Lef1-/- pro-B cells display elevated levels of fas and c-myc transcription, providing a potential mechanism for their increased sensitivity to apoptosis. Finally, we establish a link between Wnt signaling and normal B cell development by demonstrating that Wnt proteins are mitogenic for pro-B cells and that this effect is mediated by LEF-1.},
	issn = {1074-7613 (Print); 1074-7613 (Linking)},
	author = {Reya, T and O{\textquoteright}Riordan, M and Okamura, R and Devaney, E and Willert, K and Nusse, R and Grosschedl, R}
}
