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Aaron Wenger
Computer Science
Bio-X SIGF and Morgridge Family Fellow 2010
Professor Gill Bejerano (Developmental Biology, Computer Science)
The literature lists a growing number of diseases caused by improper gene regulation; however, the vast majority of the approximately one million regulatory elements in the human genome are of unknown function, and how regulatory logic is encoded in DNA sequence is not well understood. Accurate, comprehensive, and functional annotation of regulatory elements will allow the identification of causative mutations for various diseases and could suggest treatment options. Aaron works to annotate regulatory elements in the human genome by integrating large scale genome-wide experimental measurements, comparative genomics, computational learning methods, and experimental functional validation. |
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