|
|
|
 |
 |
 |
 |
 |
Larry Wang
Materials Science & Engineering
Bio-X
Graduate Student Fellowships 2007/2008
Profs. Sarah Heilshorn (Materials Science & Engineering) and Andrew Spakowitz (Chemical Engineering)
The goal of Larry’s research project is to understand the structural and behavioral characteristics of quaternary protein structure using the coat-vesicle protein clathrin. This study employs two major approaches in parallel: development of a theoretical model using Brownian dynamics simulation to predict quaternary structure and in vitro self-assembly experiments to observe and control the quaternary structure. Clathrin proteins perform their biological functions by self-assembling into cages, and recent reports have begun to elucidate the structure of the individual clathrin molecule and have provided a more detailed static picture of the in vivo assembly. |
 |
|
 |
|
|
