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Jack Wang
Neurobiology
Bio-X Graduate Student Fellow 2011/2012
Professor Ben Barres (Neurobiology)
Degeneration of the nerve fibers, or axons, is a pivot-al event and a major determinant of clinical outcome in many neurodegenerative diseases; however, the mechanisms that regulate this process remain largely unclear. Remarkably, expression of a mutant protein (WldS) significantly delays axon degeneration from many neurological insults. Through a series of genetic, biochemical and proteomic approaches, Jack propos-es to understand how this protein is able to exert such a profound neuro-protective effect. The goals of his research are to understand the molecular mecha-nisms of axon degeneration and to identify therapeu-tic targets to prevent axon loss following neurological injuries and diseases. |
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