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Jacob Hughey
Bio-X Bioengineering Graduate Fellow 2007
Professor Markus Covert (Bioengineering)
The goal of Jacob’s work is to provide a quantitative understanding of the intricate circuitry that controls how cells interact with their environment. Currently, he is focusing on the TNF-induced response of the NF-κB network, which is crucially involved in cell proliferation and the innate immune response and is misregulated in many cancers. He is using live cell imaging and mathematical modeling to explain how the dynamics of the network depend on TNF dose. This research will lead to greater understanding of how cells sense and respond to the intensity of environmental signals. |
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