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Elizabeth Chen
Stem Cell Biology and Regenerative Medicine
Bio-X SIGF Fellow 2013/2014
Profs. Michael Clarke (Medicine) and Stephen Quake (Bioengineering and Applied Physics)
Stem cells are chameleons that can interconvert between distinct populations in response to injury or physiological stimulus. Liz hopes to test how stem cells can “switch” between a phenotype characteristic of metastasizing cancer cells and a phenotype displayed by cancers with better prognosis. To do this, she hopes to develop novel microfluidic screens for gene expression and epigenetic differences between the two stem cell populations to identify mechanisms that regulate this conversion. This research will combine methods in stem cell biology, bioengineering, and bioinformatics to drive the conversion of aggressively metastasizing cancer cells into a more treatable state. |
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