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Craig Buckley
Chemical Engineering
Bio-X Graduate Student Fellow 2011/2012
Professor Alex Dunn (Chemical Engineering)
The motor protein dynein contains a component termed the linker that is predicted to generate the force that drives cytoplasmic dynein stepping along microtubules; however, its actual force-generating abilities have never been directly examined. Craig will use single molecule techniques to perform the first direct test of the hypothesis that the linker is the primary force generating mechanical element in dynein. If it is, he will map out the energetic surface underlying force production by tracking the linker swing in real time. These measurements will elucidate the mechanism of dynein force production and test fundamental models of motor protein biophysics. |
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