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Jaimie Adelson
Neurosciences
Bio-X
Graduate Student Fellowships 2010/2011
*Honorary Bio-X Fellow
Professor Carla Shatz (Biology, Neurobiology)
Our brains have the remarkable ability to change and learn. The cerebral cortex has intrinsic mechanisms that limit or promote plasticity by converting neural activity into lasting structural changes at synapses. Jaimie considers the model that, in neurons, two major histocompatibility complex class I genes, Kb and Db, signaling via the innate immune receptor PirB, act as a brake on cortical plasticity.
The goal of her research is to “release the brake” in mutant mice lacking these molecules, and examine if it is possible to not only increase cortical plasticity but also to promote faster recovery following acute cortical injury. |
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