Week 6: July 28, 2010

Genetic Ancestry


Instructor:

Carlos Bustamante, PhD
Professor of Genetics

Learning Objectives

  • Gain understanding of population structure and its implications in research studies
  • Gain understanding of ancestry inference from personal genomic data
  • Appreciate clinical and scientific applications of genetic ancestry


    • Data Exercises (Instructions)

  • Principle components analysis (PCA) to infer genetic ancestry
  • Admixture analysis with STRUCTURE


    • Lecture Slides
    Ancestry Exercise Results


    Readings

    1. Novembre et al. Genes mirror geography. Nature Nov 6;456(7218):98-101. Epub 2008 Aug 31. Erratum in: Nature. 2008 Nov 13;456(7219):274.
    2. Kumar et al. Genetic Ancestry in Lung-Function Predictions. N Engl J Med. 2010 Jul 7. [Epub ahead of print].
    3. (Optional) Auton et al. Global distribution of genomic diversity underscores rich complex history of continental human populations. Genome Res. 2009 May;19(5):795-803. Epub 2009 Feb 13.
    4. (Optional) Bryc et al. Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):786-91. Epub 2009 Dec 22.