Presenter:

Tom Dean, Google Research, [PUBS]:
Introduction to Scalable Neuroscience: Part 1 [1-7] [SLIDES]

References:

Thomas Dean. Inferring mesoscale models of neural computation. CoRR, arXiv:1710.05183, 2017. [PDF]

Thomas Dean, Maurice Chiang, Marcus Gomez, Nate Gruver, Yousef Hindy, Michelle Lam, Peter Lu, Sophia Sanchez, Rohun Saxena, Michael Smith, Lucy Wang, Catherine Wong. Amanuensis: The Programmer's Apprentice. CoRR, arXiv:1807.00082. 2018. [PDF]

Supplements:

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction: [VIDEO] SOURCE: L. Weinhard, G. di Bartolomei, G. Bolasco, P. Machado, N.L. Schieber U. Neniskyte, M. Exiga, A. Vadisiute, A. Raggioli, A. Schertel, Y. Schwab, and C.T. Gross. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction. Nature Communications Volume 9, Issue 1, 1228, 2018.

Time-lapse imaging of GFP-labeled microglia demonstrates that the fine termini of microglial processes are highly dynamic in the intact mouse cortex. Upon local brain injury, microglial processes rapidly and autonomously converge on the site of injury without cell body movement, establishing a potential barrier between the healthy and injured tissue: [VIDEO]. SOURCE: J. Tønnesen, V.V.G.K. Inavalli, and U.V. Nägeri. Super-resolution imaging of the extracellular space in living brain tissue. Cell Volume 172, Issue 5, 1108–1121, 2018.