syntenic Wnt genes

There are several cases of closely linked and syntenic Wnt genes in the human and mouse genomes, listed here. Some of the Drosophila orthologs, wingless, DWnt10 and DWnt6, are also linked. See (Nusse, 2001; PDF) for a discussion of the evolutionary implications.

Note that in Drosophila, wingless, DWnt10 and DWnt6 are immediately adjacent, while DWnt4 (the ortholog of Wnt9; Qian et al (2003) ) is very close to that cluster.

Updated/renewed April 2003

unlinked
human (chrom)	.	mouse (chrom)	Drosophila
12q13	Wnt1	15 56.8	wingless
12q13	Wnt10B	15 56.8	DWnt10
2q35	Wnt10A	1	DWnt10
2q35	Wnt6	1	DWnt6
17q21	Wnt3	11 63	no orthol.
17q21	Wnt9B	11 63	DWnt4
1q42	Wnt9A	11 32	DWnt4
1q42	Wnt3A	11 32	no orthol.
7q31	Wnt2	6	no orthol.
7q31	Wnt16	6	no orthol.
1p13	Wnt2B	3	no orthol.
1p36	Wnt4	4	no orthol.
3p21.2	Wnt5A	14	DWnt5
12p13	Wnt5B	6	DWnt5
3p25	Wnt7A	6	DWnt2
22q13	Wnt7B	15	DWnt2
5	Wnt8A	18	no orthol.
10q24	Wnt8B	19	no orthol.
11q13	Wnt11	7	no orthol.
no ortholog			WntD